MEGF6 and ATXN7

Number of citations of the paper that reports this interaction (PMID 21078624)
14

Data Source:
BioGRID (two hybrid)

		MEGF6	ATXN7
Gene Name		multiple EGF-like-domains 6	ataxin 7
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component Extracellular Region	Nucleus Nucleoplasm Nucleolus Cytoplasm Microtubule Cytoskeleton Nuclear Matrix
	Molecular Function	Calcium Ion Binding Protein Binding	Chromatin Binding Protein Binding
	Biological Process	Biological_process	Microtubule Cytoskeleton Organization Chromatin Organization Transcription, DNA-templated Nucleus Organization Visual Perception Histone Deubiquitination Negative Regulation Of Phosphorylation Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways			Chromatin modifying enzymes Chromatin organization HATs acetylate histones
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: ATN1 ATXN7 CACNA1A CRKL EGFR GFI1B MFAP5	59 interactors: ACTN1 ACTN2 ACTN4 ADAM33 AGRN CARD10 CEP70 CEP72 COG6 CRIM1 CRX EFEMP1 EFEMP2 FBN1 FN1 GOLGA2 GOLGA3 GPRASP1 GRN HIST1H3A JAG2 KALRN KAT2A LAMB1 LAMB2 LRSAM1 LTBP4 MATN2 MEGF6 MPRIP NELL1 NELL2 NOC2L NUP62 PICK1 PNMA1 PPP1R12C PSMC1 RABEP1 RAD23A RNF31 SIAH1 SNX1 SPRY1 SSFA2 SUMO1 SUMO2 TAF10 THY1 TP53BP2 TRAF2 TRIM23 TRIM27 TRIM54 TRRAP TXNDC11 UBQLN2 VCP VWF
Entrez ID		1953	6314
HPRD ID		11973	06365
Ensembl ID			ENSG00000163635
Uniprot IDs		O75095	O15265 Q9UPD8
PDB IDs			2KKR
Enriched GO Terms of Interacting Partners?		Activation Of MAPKK Activity Alkanesulfonate Metabolic Process Cerebellar Molecular Layer Development Vestibular Nucleus Development Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Astrocyte Activation Cerebellum Maturation Musculoskeletal Movement, Spinal Reflex Action Regulation Of Transcription From RNA Polymerase II Promoter Activation Of Phospholipase A2 Activity Gamma-aminobutyric Acid Secretion Positive Regulation Of Phospholipase A2 Activity Regulation Of Acetylcholine Secretion, Neurotransmission Neurotrophin TRK Receptor Signaling Pathway Response To Cobalamin Response To UV-A Rhythmic Synaptic Transmission Negative Regulation Of Cellular Metabolic Process Neurotrophin Signaling Pathway MAPK Cascade Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Response To Hydroxyisoflavone Central Nervous System Development Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Cellular Chloride Ion Homeostasis Calcium Ion-dependent Exocytosis Of Neurotransmitter System Development Activation Of Protein Kinase Activity Chloride Ion Homeostasis Gamma-aminobutyric Acid Transport Signal Transduction By Phosphorylation Positive Regulation Of Catenin Import Into Nucleus Parathyroid Gland Development Negative Regulation Of Hormone Biosynthetic Process Extracellular Fibril Organization Regulation Of Synaptic Transmission Regulation Of Phospholipase A2 Activity Pons Development Maintenance Of Cell Polarity Neurological System Process Regulation Of Superoxide Anion Generation Toxin Metabolic Process Sulfur Compound Metabolic Process Magnesium Ion Homeostasis Cerebellar Purkinje Cell Differentiation Multicellular Organismal Development Protein Localization To Membrane Regulation Of Phosphorylation Regulation Of Metabolic Process	Extracellular Matrix Organization Extracellular Structure Organization Response To Stimulus Cell-substrate Junction Assembly Cell-substrate Adhesion Platelet Degranulation Cellular Localization Protein Modification By Small Protein Conjugation Regulation Of Proteolysis Vesicle-mediated Transport Regulation Of Protein Metabolic Process Establishment Of Localization In Cell Cell Junction Assembly Protein Localization To Tight Junction Regulation Of Metabolic Process Histone Deubiquitination Regulation Of Cellular Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Apoptotic Process Cellular Response To Stimulus Regulation Of Cellular Protein Metabolic Process Response To Wounding Regulation Of Protein Catabolic Process Regulation Of Cell Death Protein Ubiquitination Protein Polyubiquitination Blood Coagulation Cellular Protein Modification Process Hemostasis Positive Regulation Of Proteolysis Focal Adhesion Assembly Cellular Component Assembly Protein Localization Extracellular Matrix Disassembly Platelet Activation Regulation Of Signal Transduction Regulation Of Proteasomal Protein Catabolic Process Protein Complex Assembly Regulation Of Signaling Cellular Protein Metabolic Process Protein Localization To Cell Junction Cell Death Death Response To Stress Nervous System Development Positive Regulation Of Protein Catabolic Process Secretion By Cell Substrate Adhesion-dependent Cell Spreading Adherens Junction Assembly Protein Metabolic Process
Tagcloud ?			accounts asian ataxia ataxias atn1 atxn1 atxn2 atxn3 cag caucasians causal causative consortium ethnic expanded expansions explained geographical htt influenced modifier polyglutamine quadratic reflected replicated sister spinocerebellar tbp variability
Tagcloud (Difference) ?			accounts asian ataxia ataxias atn1 atxn1 atxn2 atxn3 cag caucasians causal causative consortium ethnic expanded expansions explained geographical htt influenced modifier polyglutamine quadratic reflected replicated sister spinocerebellar tbp variability
Tagcloud (Intersection) ?