EGF and PIK3R2

Number of citations of the paper that reports this interaction (PMID 1334406)
14

Data Source:
HPRD (in vivo)

		EGF	PIK3R2
Gene Name		epidermal growth factor	phosphoinositide-3-kinase, regulatory subunit 2 (beta)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosomal Membrane Plasma Membrane Integral Component Of Membrane Platelet Alpha Granule Lumen Extracellular Vesicular Exosome	Nucleus Cytosol Phosphatidylinositol 3-kinase Complex
	Molecular Function	Epidermal Growth Factor Receptor Binding Calcium Ion Binding Protein Binding Growth Factor Activity Transmembrane Receptor Protein Tyrosine Kinase Activator Activity	Protein Binding 1-phosphatidylinositol-3-kinase Activity Protein Phosphatase Binding Receptor Tyrosine Kinase Binding Phosphatidylinositol 3-kinase Regulator Activity
	Biological Process	Activation Of MAPKK Activity Angiogenesis Platelet Degranulation DNA Replication Signal Transduction Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway STAT Protein Import Into Nucleus Blood Coagulation Positive Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cerebellar Granule Cell Precursor Proliferation Platelet Activation Positive Regulation Of Catenin Import Into Nucleus Fc-epsilon Receptor Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Phosphorylation Positive Regulation Of DNA Binding Positive Regulation Of MAP Kinase Activity Innate Immune Response Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription, DNA-templated Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Branching Morphogenesis Of An Epithelial Tube Negative Regulation Of Secretion Mammary Gland Alveolus Development ERK1 And ERK2 Cascade Regulation Of Calcium Ion Import Negative Regulation Of Cholesterol Efflux Positive Regulation Of Hyaluronan Biosynthetic Process Regulation Of Protein Localization To Cell Surface Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process	Cellular Glucose Homeostasis Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Epidermal Growth Factor Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Blood Coagulation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Autophagy Phosphatidylinositol 3-kinase Signaling Cellular Response To Insulin Stimulus Response To Endoplasmic Reticulum Stress Phosphatidylinositol-3-phosphate Biosynthetic Process Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Transcription Factor Import Into Nucleus Regulation Of Phosphatidylinositol 3-kinase Activity Small Molecule Metabolic Process Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling T Cell Receptor Signaling Pathway Leukocyte Migration Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Platelet degranulation Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling Signaling by SCF-KIT SHC1 events in ERBB2 signaling Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants GRB2 events in ERBB2 signaling PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Response to elevated platelet cytosolic Ca2+ Innate Immune System Signaling by PDGF EGFR downregulation Signalling by NGF DAP12 interactions GAB1 signalosome GRB2 events in EGFR signaling Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Inhibition of Signaling by Overexpressed EGFR Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by FGFR EGFR interacts with phospholipase C-gamma Signaling by ERBB2 Signaling by EGFR SHC1 events in EGFR signaling Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Constitutive Signaling by EGFRvIII Platelet activation, signaling and aggregation Adaptive Immune System	Signaling by the B Cell Receptor (BCR) Signaling by GPCR Metabolism of lipids and lipoproteins Signaling by FGFR in disease Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation Interleukin receptor SHC signaling PI-3K cascade Gastrin-CREB signalling pathway via PKC and MAPK Interleukin-7 signaling Role of phospholipids in phagocytosis Phospholipid metabolism Fcgamma receptor (FCGR) dependent phagocytosis PI3K Cascade Signaling by PDGF DAP12 interactions GAB1 signalosome G-protein beta:gamma signalling CD28 co-stimulation CD28 dependent PI3K/Akt signaling Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by ERBB2 G alpha (q) signalling events Signaling by EGFR GPCR downstream signaling Signaling by Interleukins TCR signaling Signaling by VEGF Signaling by Rho GTPases Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Nephrin interactions Interleukin-2 signaling PI3K/AKT Signaling in Cancer Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling Adaptive Immune System G alpha (q) signalling events Downstream TCR signaling Costimulation by the CD28 family IRS-mediated signalling PIP3 activates AKT signaling IGF1R signaling cascade VEGFA-VEGFR2 Pathway Rho GTPase cycle Synthesis of PIPs at the plasma membrane IRS-related events triggered by IGF1R G beta:gamma signalling through PI3Kgamma PI3K events in ERBB2 signaling Regulation of signaling by CBL Downstream signaling of activated FGFR G alpha (12/13) signalling events PI Metabolism Innate Immune System Signaling by Insulin receptor Signalling by NGF Insulin receptor signalling cascade IRS-related events Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Tie2 Signaling Signaling by Overexpressed Wild-Type EGFR in Cancer Cell surface interactions at the vascular wall Signaling by FGFR IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) GPVI-mediated activation cascade Interleukin receptor SHC signaling PI3K Cascade
Drugs		Sucralfate Alpha-Aminobutyric Acid
Diseases
GWAS		Hair morphology ( 19896111)
Protein-Protein Interactions		12 interactors: ADAM12 ADRBK1 CPM DUSP3 EGFR ERBB2 ERBB3 GRB2 LMNA NRG1 PIK3R2 VTN	51 interactors: APP ARRB1 AXL CBL CD28 CRKL CSF1 CSF1R DYDC1 EGF EGFR EPHA2 ERBB2 ERBB3 ERBB4 FBXL2 FGFR1 FYN GOLGA2 GRB2 GRN HCK IGF1R IKZF3 IRS1 IRS2 KIT KRAS KRT15 KRT20 KRT38 LAMB2 LTBP3 MRFAP1L1 PDGFRB PIK3CD RINT1 SEPT2 SHC1 SOCS1 SOCS6 SOCS7 SOS1 STAB1 SYK TEC TGFBR1 TGFBR2 TRIM23 WASF3 YWHAB
Entrez ID		1950	5296
HPRD ID		00578	04404
Ensembl ID		ENSG00000138798	ENSG00000105647
Uniprot IDs		P01133	O00459
PDB IDs		1IVO 1JL9 1NQL 1P9J 2KV4 3NJP	2KT1 2XS6 3MTT 3O5Z
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Innate Immune Response Enzyme Linked Receptor Protein Signaling Pathway Phosphatidylinositol-mediated Signaling Cellular Response To Growth Factor Stimulus Response To Growth Factor Fc-epsilon Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Immune Response Regulation Of Phosphorylation Defense Response Regulation Of Immune Response Fc Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Organic Substance Regulation Of Signal Transduction Regulation Of Kinase Activity Regulation Of Immune System Process Regulation Of Signaling Immune System Process Regulation Of Catalytic Activity Phosphatidylinositol 3-kinase Signaling Response To Stress Regulation Of Protein Phosphorylation Regulation Of Cell Adhesion Negative Regulation Of Signal Transduction Response To Organic Substance Anatomical Structure Development Negative Regulation Of Signaling Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Developmental Process Glial Cell Differentiation Positive Regulation Of Phosphorylation Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Kinase Activity Positive Regulation Of Protein Modification Process Positive Regulation Of Kinase Activity Regulation Of Peptidyl-tyrosine Phosphorylation Heart Development Positive Regulation Of Metabolic Process Gliogenesis	Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fc Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Fc-epsilon Receptor Signaling Pathway Response To Fibroblast Growth Factor Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Response To Growth Factor Innate Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Phosphatidylinositol-mediated Signaling Immune Response-regulating Signaling Pathway Regulation Of Kinase Activity Intracellular Signal Transduction Cellular Response To Organic Substance Defense Response Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Immune System Process Immune Response Regulation Of Immune System Process Regulation Of Phosphorylation Peptidyl-tyrosine Phosphorylation Positive Regulation Of Intracellular Signal Transduction Response To Organic Substance Regulation Of Phosphorus Metabolic Process Regulation Of Signal Transduction Regulation Of Signaling Positive Regulation Of Cell Proliferation Positive Regulation Of Signal Transduction Response To Stress Regulation Of Protein Kinase Activity Regulation Of Immune Response Regulation Of Cell Proliferation Regulation Of Protein Phosphorylation Positive Regulation Of Kinase Activity Developmental Process Positive Regulation Of Transferase Activity Regulation Of Catalytic Activity Signal Transduction Signaling Anatomical Structure Development Positive Regulation Of Phosphorylation Regulation Of MAPK Cascade Cell Communication
Tagcloud ?		adulthood already autocrine cloned gh hyperplasia islet islets lactogen man mitotic motifs mutational neogenesis pancreas pl place placental preadipocyte pref pregnancy prl prolactin pronounced putative rodents stat1 stat5 take ways	acetylated acetylations chip contrary deacetylase deacetylases distally dysregulated encompassing facilitates featured h2a h3k9 hexokinase hk2 irs2 l6 lysines myotubes p85beta pharmacologically responsive reverted template treatable trichostatin tsa tss z
Tagcloud (Difference) ?		adulthood already autocrine cloned gh hyperplasia islet islets lactogen man mitotic motifs mutational neogenesis pancreas pl place placental preadipocyte pref pregnancy prl prolactin pronounced putative rodents stat1 stat5 take ways	acetylated acetylations chip contrary deacetylase deacetylases distally dysregulated encompassing facilitates featured h2a h3k9 hexokinase hk2 irs2 l6 lysines myotubes p85beta pharmacologically responsive reverted template treatable trichostatin tsa tss z
Tagcloud (Intersection) ?