EGF and NRG1

Number of citations of the paper that reports this interaction (PMID 7730382)
13

Data Source:
HPRD (in vitro)

		EGF	NRG1
Gene Name		epidermal growth factor	neuregulin 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosomal Membrane Plasma Membrane Integral Component Of Membrane Platelet Alpha Granule Lumen Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Nucleus Cytoplasm Integral Component Of Plasma Membrane Membrane Apical Plasma Membrane Axon Neuromuscular Junction
	Molecular Function	Epidermal Growth Factor Receptor Binding Calcium Ion Binding Protein Binding Growth Factor Activity Transmembrane Receptor Protein Tyrosine Kinase Activator Activity	Transcription Cofactor Activity Receptor Binding Cytokine Activity ErbB-2 Class Receptor Binding Protein Binding Growth Factor Activity Protein Tyrosine Kinase Activator Activity Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Receptor Tyrosine Kinase Binding ErbB-3 Class Receptor Binding
	Biological Process	Activation Of MAPKK Activity Angiogenesis Platelet Degranulation DNA Replication Signal Transduction Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway STAT Protein Import Into Nucleus Blood Coagulation Positive Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cerebellar Granule Cell Precursor Proliferation Platelet Activation Positive Regulation Of Catenin Import Into Nucleus Fc-epsilon Receptor Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Phosphorylation Positive Regulation Of DNA Binding Positive Regulation Of MAP Kinase Activity Innate Immune Response Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription, DNA-templated Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Branching Morphogenesis Of An Epithelial Tube Negative Regulation Of Secretion Mammary Gland Alveolus Development ERK1 And ERK2 Cascade Regulation Of Calcium Ion Import Negative Regulation Of Cholesterol Efflux Positive Regulation Of Hyaluronan Biosynthetic Process Regulation Of Protein Localization To Cell Surface Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process	MAPK Cascade Cell Morphogenesis Cardiac Conduction System Development Ventricular Trabecula Myocardium Morphogenesis Cell Communication Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Nervous System Development Synapse Assembly Peripheral Nervous System Development Locomotory Behavior Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Embryo Development Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Neural Crest Cell Development Cell Migration Glial Cell Fate Commitment Positive Regulation Of Cell Growth Mammary Gland Development Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway ERBB Signaling Pathway Wound Healing Negative Regulation Of Protein Catabolic Process Regulation Of Protein Homodimerization Activity Regulation Of Protein Heterodimerization Activity Cellular Protein Complex Disassembly Innate Immune Response Neurotransmitter Receptor Metabolic Process Positive Regulation Of Cell Adhesion Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Ras Protein Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Neuron Fate Commitment Negative Regulation Of Secretion Positive Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Protein Kinase B Signaling Cardiac Muscle Cell Differentiation Ventricular Cardiac Muscle Cell Differentiation Positive Regulation Of Cardiac Muscle Cell Proliferation Cardiac Muscle Cell Myoblast Differentiation Endocardial Cell Differentiation Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Cardiac Muscle Cell Differentiation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Platelet degranulation Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling Signaling by SCF-KIT SHC1 events in ERBB2 signaling Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants GRB2 events in ERBB2 signaling PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Response to elevated platelet cytosolic Ca2+ Innate Immune System Signaling by PDGF EGFR downregulation Signalling by NGF DAP12 interactions GAB1 signalosome GRB2 events in EGFR signaling Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Inhibition of Signaling by Overexpressed EGFR Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by FGFR EGFR interacts with phospholipase C-gamma Signaling by ERBB2 Signaling by EGFR SHC1 events in EGFR signaling Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Constitutive Signaling by EGFRvIII Platelet activation, signaling and aggregation Adaptive Immune System	Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling GRB7 events in ERBB2 signaling Signaling by EGFRvIII in Cancer Signaling by SCF-KIT SHC1 events in ERBB2 signaling Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF Downregulation of ERBB2:ERBB3 signaling Signalling by NGF DAP12 interactions GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Nuclear signaling by ERBB4 SHC1 events in ERBB4 signaling Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs		Sucralfate Alpha-Aminobutyric Acid
Diseases
GWAS		Hair morphology ( 19896111)	Cardiac Troponin-T levels ( 23247143) Dialysis-related mortality ( 21546767) Hip geometry ( 17903296) Hirschsprung's disease ( 19196962) Thyroid cancer ( 22267200) Thyroid hormone levels ( 23408906)
Protein-Protein Interactions		12 interactors: ADAM12 ADRBK1 CPM DUSP3 EGFR ERBB2 ERBB3 GRB2 LMNA NRG1 PIK3R2 VTN	7 interactors: ADAM19 EGF ERBB2 ERBB3 ERBB4 IKZF4 LIMK1
Entrez ID		1950	3084
HPRD ID		00578	00802
Ensembl ID		ENSG00000138798	ENSG00000157168
Uniprot IDs		P01133	A6MW55 A6MW56 B0FWZ3 B0FYA7 B0FYA8 B0FYA9 B7Z1D7 B7Z1E3 Q02297 Q6PK61 Q7RTW3 Q7RTW5
PDB IDs		1IVO 1JL9 1NQL 1P9J 2KV4 3NJP	1HAE 1HAF 1HRE 1HRF 3U7U
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Innate Immune Response Enzyme Linked Receptor Protein Signaling Pathway Phosphatidylinositol-mediated Signaling Cellular Response To Growth Factor Stimulus Response To Growth Factor Fc-epsilon Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Immune Response Regulation Of Phosphorylation Defense Response Regulation Of Immune Response Fc Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Organic Substance Regulation Of Signal Transduction Regulation Of Kinase Activity Regulation Of Immune System Process Regulation Of Signaling Immune System Process Regulation Of Catalytic Activity Phosphatidylinositol 3-kinase Signaling Response To Stress Regulation Of Protein Phosphorylation Regulation Of Cell Adhesion Negative Regulation Of Signal Transduction Response To Organic Substance Anatomical Structure Development Negative Regulation Of Signaling Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Developmental Process Glial Cell Differentiation Positive Regulation Of Phosphorylation Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Kinase Activity Positive Regulation Of Protein Modification Process Positive Regulation Of Kinase Activity Regulation Of Peptidyl-tyrosine Phosphorylation Heart Development Positive Regulation Of Metabolic Process Gliogenesis	Fc Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Immune Response-regulating Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Peptidyl-tyrosine Phosphorylation Innate Immune Response Cardiovascular System Development Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Kinase Activity Heart Development Positive Regulation Of Peptidyl-tyrosine Phosphorylation Immune Response Regulation Of Immune System Process Protein Phosphorylation Positive Regulation Of Transferase Activity Defense Response Cellular Response To Growth Factor Stimulus Wound Healing Response To Growth Factor Phosphatidylinositol 3-kinase Signaling Regulation Of Peptidyl-tyrosine Phosphorylation Response To Wounding Positive Regulation Of Protein Phosphorylation Positive Regulation Of Growth Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Phosphorylation Phosphorylation Signal Transduction By Phosphorylation Intracellular Signal Transduction Positive Regulation Of Protein Modification Process Mammary Gland Lobule Development Mammary Gland Alveolus Development Regulation Of Cellular Protein Metabolic Process Peptidyl-amino Acid Modification Immune System Process Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Protein Tyrosine Kinase Activity
Tagcloud ?		adulthood already autocrine cloned gh hyperplasia islet islets lactogen man mitotic motifs mutational neogenesis pancreas pl place placental preadipocyte pref pregnancy prl prolactin pronounced putative rodents stat1 stat5 take ways	appreciated cardiac cardiomyocyte cardiomyocytes cardiomyopathy chamber conscious contractility dilatation dilated dilation echocardiography ecs ejection erbb fractional hearts isoproterenol mechanistically neuregulin normalization normalized paracrine pecam proper shortening systolic tightly
Tagcloud (Difference) ?		adulthood already autocrine cloned gh hyperplasia islet islets lactogen man mitotic motifs mutational neogenesis pancreas pl place placental preadipocyte pref pregnancy prl prolactin pronounced putative rodents stat1 stat5 take ways	appreciated cardiac cardiomyocyte cardiomyocytes cardiomyopathy chamber conscious contractility dilatation dilated dilation echocardiography ecs ejection erbb fractional hearts isoproterenol mechanistically neuregulin normalization normalized paracrine pecam proper shortening systolic tightly
Tagcloud (Intersection) ?