EGF

Gene Name		epidermal growth factor
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosomal Membrane Plasma Membrane Integral Component Of Membrane Platelet Alpha Granule Lumen Extracellular Vesicular Exosome
	Molecular Function	Epidermal Growth Factor Receptor Binding Calcium Ion Binding Protein Binding Growth Factor Activity Transmembrane Receptor Protein Tyrosine Kinase Activator Activity
	Biological Process	Activation Of MAPKK Activity Angiogenesis Platelet Degranulation DNA Replication Signal Transduction Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway STAT Protein Import Into Nucleus Blood Coagulation Positive Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cerebellar Granule Cell Precursor Proliferation Platelet Activation Positive Regulation Of Catenin Import Into Nucleus Fc-epsilon Receptor Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Phosphorylation Positive Regulation Of DNA Binding Positive Regulation Of MAP Kinase Activity Innate Immune Response Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription, DNA-templated Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Branching Morphogenesis Of An Epithelial Tube Negative Regulation Of Secretion Mammary Gland Alveolus Development ERK1 And ERK2 Cascade Regulation Of Calcium Ion Import Negative Regulation Of Cholesterol Efflux Positive Regulation Of Hyaluronan Biosynthetic Process Regulation Of Protein Localization To Cell Surface Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Platelet degranulation Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling Signaling by SCF-KIT SHC1 events in ERBB2 signaling Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants GRB2 events in ERBB2 signaling PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Response to elevated platelet cytosolic Ca2+ Innate Immune System Signaling by PDGF EGFR downregulation Signalling by NGF DAP12 interactions GAB1 signalosome GRB2 events in EGFR signaling Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Inhibition of Signaling by Overexpressed EGFR Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by FGFR EGFR interacts with phospholipase C-gamma Signaling by ERBB2 Signaling by EGFR SHC1 events in EGFR signaling Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Constitutive Signaling by EGFRvIII Platelet activation, signaling and aggregation Adaptive Immune System
Drugs		Sucralfate Alpha-Aminobutyric Acid
Diseases
GWAS		Hair morphology ( 19896111)
Protein-protein Interactions		12 interactors: ADAM12 ADRBK1 CPM DUSP3 EGFR ERBB2 ERBB3 GRB2 LMNA NRG1 PIK3R2 VTN
Entrez ID		1950
HPRD ID		00578
Ensembl ID		ENSG00000138798
Uniprot IDs		P01133
PDB IDs		1IVO 1JL9 1NQL 1P9J 2KV4 3NJP
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Innate Immune Response Enzyme Linked Receptor Protein Signaling Pathway Phosphatidylinositol-mediated Signaling Cellular Response To Growth Factor Stimulus Response To Growth Factor Fc-epsilon Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Immune Response Regulation Of Phosphorylation Defense Response Regulation Of Immune Response Fc Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Organic Substance Regulation Of Signal Transduction Regulation Of Kinase Activity Regulation Of Immune System Process Regulation Of Signaling Immune System Process Regulation Of Catalytic Activity Phosphatidylinositol 3-kinase Signaling Response To Stress Regulation Of Protein Phosphorylation Regulation Of Cell Adhesion Negative Regulation Of Signal Transduction Response To Organic Substance Anatomical Structure Development Negative Regulation Of Signaling Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Developmental Process Glial Cell Differentiation Positive Regulation Of Phosphorylation Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Kinase Activity Positive Regulation Of Protein Modification Process Positive Regulation Of Kinase Activity Regulation Of Peptidyl-tyrosine Phosphorylation Heart Development Positive Regulation Of Metabolic Process Gliogenesis
Tagcloud ?		adulthood already autocrine cloned gh hyperplasia islet islets lactogen man mitotic motifs mutational neogenesis pancreas pl place placental preadipocyte pref pregnancy prl prolactin pronounced putative rodents stat1 stat5 take ways