EGF

Description		epidermal growth factor
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosomal Membrane Plasma Membrane Membrane Clathrin-coated Endocytic Vesicle Membrane Platelet Alpha Granule Lumen Extracellular Exosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Epidermal Growth Factor Receptor Binding Calcium Ion Binding Protein Binding Growth Factor Activity Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Receptor Ligand Activity
	Biological Process	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Positive Regulation Of Receptor Internalization Epidermal Growth Factor Receptor Signaling Pathway Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Peptidyl-threonine Phosphorylation Cerebellar Granule Cell Precursor Proliferation Positive Regulation Of Cerebellar Granule Cell Precursor Proliferation Positive Regulation Of Cell Migration ERBB2-EGFR Signaling Pathway Positive Regulation Of Phosphorylation Positive Regulation Of DNA Binding Positive Regulation Of MAPK Cascade Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of DNA-templated Transcription Regulation Of Receptor Signaling Pathway Via JAK-STAT System Development Branching Morphogenesis Of An Epithelial Tube Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Secretion Regulation Of Transport Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Mammary Gland Alveolus Development ERK1 And ERK2 Cascade Regulation Of Primary Metabolic Process Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Calcium Ion Import Negative Regulation Of Cholesterol Efflux Positive Regulation Of Hyaluronan Biosynthetic Process Positive Regulation Of Protein Localization To Early Endosome Positive Regulation Of Epithelial Tube Formation Regulation Of Protein Localization To Cell Surface Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		Platelet degranulation Signaling by ERBB2 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Signaling by ERBB4 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling PLCG1 events in ERBB2 signaling PIP3 activates AKT signaling Signaling by EGFR Signaling by EGFR GRB2 events in EGFR signaling GAB1 signalosome SHC1 events in EGFR signaling EGFR downregulation GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling EGFR interacts with phospholipase C-gamma Constitutive Signaling by Aberrant PI3K in Cancer Constitutive Signaling by EGFRvIII Inhibition of Signaling by Overexpressed EGFR RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Downregulation of ERBB2 signaling Extra-nuclear estrogen signaling NOTCH3 Activation and Transmission of Signal to the Nucleus Estrogen-dependent nuclear events downstream of ESR-membrane signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin NFE2L2 regulating tumorigenic genes Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Myoepithelial Cells Developmental Lineage of Multipotent Pancreatic Progenitor Cells
Drugs		Sucralfate Alpha-Aminobutyric Acid Cholecystokinin Tesevatinib Oleandrin
Diseases		Gastric cancer
GWAS		Albumin-globulin ratio ( 29403010) Blood protein levels ( 30072576) Glycated hemoglobin levels ( 34059833) Hair morphology ( 19896111) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Lymphocyte count ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 29403010) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) Non-albumin protein levels ( 29403010) Platelet count ( 32888494 33545615 27863252 29403010) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 27863252 32888494) Spleen volume ( 34128465) Waist-to-hip ratio adjusted for BMI ( 28552196)
Interacting Genes		14 interacting genes: ADAM12 CPM DUSP3 EGFR ERBB2 ERBB3 GRB2 GRK2 LMNA MGST1 NRG1 PIK3R1 PIK3R2 VTN
Entrez ID		1950
HPRD ID		00578
Ensembl ID		ENSG00000138798
Uniprot IDs		A0A494C018 P01133
PDB IDs		1IVO 1JL9 1NQL 1P9J 2KV4 3NJP 7OM4 7SYD 7SYE 7SZ0 7SZ1 8HGO 8HGS
Enriched GO Terms of Interacting Partners?		ErbB-3 Class Receptor Binding ERBB Signaling Pathway ERBB2 Signaling Pathway Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Regulation Of Cell Adhesion Receptor Tyrosine Kinase Binding Epidermal Growth Factor Receptor Signaling Pathway Protein Tyrosine Kinase Activator Activity Regulation Of MAPK Cascade Enzyme-linked Receptor Protein Signaling Pathway Schwann Cell Development ERBB3:ERBB2 Complex Regulation Of Multicellular Organismal Process Protein Phosphatase Binding Regulation Of Signal Transduction Peripheral Nervous System Development Regulation Of Cell Communication Regulation Of Signaling ERBB2-ERBB4 Signaling Pathway Cellular Response To Epidermal Growth Factor Stimulus Phosphotyrosine Residue Binding Response To Epidermal Growth Factor Neurotrophin TRKA Receptor Binding 1-phosphatidylinositol-3-kinase Regulator Activity Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Focal Adhesion Disassembly ERBB2-EGFR Signaling Pathway Glial Cell Development Basal Plasma Membrane Developmental Process ERBB4 Signaling Pathway Phosphatidylinositol 3-kinase Complex, Class IA Phosphatidylinositol 3-kinase Regulatory Subunit Binding Regulation Of Cellular Component Organization Wound Healing Intracellular Signaling Cassette Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Adhesion Insulin Receptor Signaling Pathway Negative Regulation Of Programmed Cell Death Negative Regulation Of Signal Transduction Animal Organ Development Cell Surface Receptor Signaling Pathway Insulin Receptor Substrate Binding Regulation Of Intracellular Signal Transduction Myelination Axon Ensheathment
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