E2F2 and TFDP1

Number of citations of the paper that reports this interaction (PMID 7739537)
49

Data Source:
BioGRID (imaging technique)
HPRD (in vivo)

		E2F2	TFDP1
Gene Name		E2F transcription factor 2	transcription factor Dp-1
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Transcription Factor Complex	Nucleoplasm Transcription Factor Complex
	Molecular Function	Core Promoter Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Transcription Factor Binding Protein Domain Specific Binding
	Biological Process	Mitotic Cell Cycle Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Lens Fiber Cell Apoptotic Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Apoptotic Process Transforming Growth Factor Beta Receptor Signaling Pathway Notch Signaling Pathway Cell Proliferation Epidermis Development Gene Expression Anoikis Positive Regulation Of Transcription From RNA Polymerase II Promoter Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of DNA Biosynthetic Process
Pathways		DNA Replication Pre-Initiation Cellular Senescence G1 Phase M/G1 Transition Regulation of DNA replication CDC6 association with the ORC:origin complex Oncogene Induced Senescence Cell Cycle, Mitotic Assembly of the pre-replicative complex Cyclin D associated events in G1 Oxidative Stress Induced Senescence Association of licensing factors with the pre-replicative complex Mitotic G1-G1/S phases	Loss of Function of TGFBR2 in Cancer Cellular Senescence SMAD2/3 MH2 Domain Mutants in Cancer Activation of BH3-only proteins Oncogene Induced Senescence TGFBR1 LBD Mutants in Cancer SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Generic Transcription Pathway Pre-NOTCH Transcription and Translation G1/S Transition G1/S-Specific Transcription Programmed Cell Death Pre-NOTCH Expression and Processing Mitotic G1-G1/S phases Intrinsic Pathway for Apoptosis E2F mediated regulation of DNA replication TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer Signaling by NOTCH TGFBR2 Kinase Domain Mutants in Cancer G1 Phase Loss of Function of SMAD4 in Cancer G0 and Early G1 TGFBR1 KD Mutants in Cancer Cell Cycle, Mitotic Loss of Function of TGFBR1 in Cancer Activation of NOXA and translocation to mitochondria Cyclin D associated events in G1 Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex Oxidative Stress Induced Senescence Activation of PUMA and translocation to mitochondria Inhibition of replication initiation of damaged DNA by RB1/E2F1 SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		17 interactors: ARID3A ATAD2 BCAR1 BRD2 CDK3 FHL2 GIT2 GNB5 RB1 RNF144A RYBP SETD8 SP1 SPIB TFDP1 TFDP2 YY1	16 interactors: CDK1 CDK2 CDK6 CREBBP E2F1 E2F2 E2F3 E2F4 E2F5 E2F6 NPDC1 SERTAD2 SIAH1 SOCS3 TP53 TP53BP1
Entrez ID		1870	7027
HPRD ID		02692	01792
Ensembl ID		ENSG00000007968	ENSG00000198176
Uniprot IDs		Q14209	B4DLQ9 F5H452 Q14186
PDB IDs		1N4M	2AZE
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Enucleate Erythrocyte Differentiation Positive Regulation Of Cellular Biosynthetic Process Mitotic Cell Cycle Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cellular Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process G1/S Transition Of Mitotic Cell Cycle Cell Division Positive Regulation Of Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Androgen Receptor Signaling Pathway DNA-templated Transcription, Initiation Chromosome Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Growth Factor Stimulus Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Chromatin Modification Response To Growth Factor Negative Regulation Of Transcription, DNA-templated Sequestering Of Nodal From Receptor Via Nodal Binding Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process	Mitotic Cell Cycle Cell Cycle Positive Regulation Of Gene Expression G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Positive Regulation Of Transcription, DNA-templated Notch Signaling Pathway Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Mitotic Cell Cycle Process Transcription, DNA-templated RNA Biosynthetic Process DNA-templated Transcription, Initiation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Signal Transduction By P53 Class Mediator Regulation Of Cell Cycle Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cell Cycle Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Lens Fiber Cell Apoptotic Process DNA Damage Checkpoint Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator RNA Metabolic Process Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Gene Expression Cell Cycle Checkpoint Regulation Of Cell Proliferation Positive Regulation Of Transcription From RNA Polymerase II Promoter Mitotic DNA Damage Checkpoint Cell Surface Receptor Signaling Pathway Regulation Of Fibroblast Proliferation
Tagcloud ?		accordingly acting collectively documented downregulates escc esophageal exerted harbor heterogeneity inactive microrna micrornas mir negatively oncogenes p21 personalized pleiotropically reversed speculate stk40 subgroup supporting suppressive te undetectable upstream virtually	accounts adenocarcinoma applicable assist deaths diagnostics e2f6 effort expended facilitate gold hmga1 hnrpd interactome irf1 lung mirna nsclc qpcr rbl1 screen silico sub suitable suv39h1 transcriptomics vital worldwide
Tagcloud (Difference) ?		accordingly acting collectively documented downregulates escc esophageal exerted harbor heterogeneity inactive microrna micrornas mir negatively oncogenes p21 personalized pleiotropically reversed speculate stk40 subgroup supporting suppressive te undetectable upstream virtually	accounts adenocarcinoma applicable assist deaths diagnostics e2f6 effort expended facilitate gold hmga1 hnrpd interactome irf1 lung mirna nsclc qpcr rbl1 screen silico sub suitable suv39h1 transcriptomics vital worldwide
Tagcloud (Intersection) ?