E2F2 and KMT5A

Number of citations of the paper that reports this interaction (PubMedID 12411495)
42

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		E2F2	KMT5A
Description		E2F transcription factor 2	lysine methyltransferase 5A
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Rb-E2F Complex RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus Nucleoplasm Chromosome Polytene Chromosome Cytosol
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding	Transcription Corepressor Activity Protein Binding Methyltransferase Activity Lysine N-methyltransferase Activity Protein-lysine N-methyltransferase Activity Transferase Activity Histone Methyltransferase Activity Histone H4K20 Methyltransferase Activity Histone H4 Methyltransferase Activity Histone H4K20 Monomethyltransferase Activity
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Sprouting Angiogenesis Lens Fiber Cell Apoptotic Process	Negative Regulation Of Transcription By RNA Polymerase II Double-strand Break Repair Via Homologous Recombination Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Mitotic Chromosome Condensation Peptidyl-lysine Monomethylation Replication Fork Processing Methylation Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of DNA-templated Transcription Cell Division Protein Localization To Chromatin Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways		Oxidative Stress Induced Senescence Oncogene Induced Senescence Cyclin D associated events in G1 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	Condensation of Prophase Chromosomes PKMTs methylate histone lysines Regulation of TP53 Activity through Methylation Negative Regulation of CDH1 Gene Transcription
Drugs
Diseases
GWAS		Eosinophil count ( 27863252 32888494) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Lymphocyte count ( 32888494) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 28957414 27863252 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Severe insulin-resistant type 2 diabetes ( 34737425) Sum eosinophil basophil counts ( 27863252) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494 27863252)	Alanine aminotransferase levels ( 33547301) Appendicular lean mass ( 33097823) Autism spectrum disorder or schizophrenia ( 28540026) High density lipoprotein cholesterol levels ( 29403010)
Interacting Genes		20 interacting genes: ARID3A ATAD2 BCAR1 BRD2 CCNF CDK3 FHL2 GIT2 GNB5 GRB2 KMT5A RB1 RNF144A RYBP SP1 SPIB TFDP1 TFDP2 UCHL5 YY1	14 interacting genes: BTRC DTL E2F2 FAM9A H4C1 H4C16 PCNA RNF168 RNF8 TCF7L2 TP53 TWIST1 UBE2I USP17L2
Entrez ID		1870	387893
HPRD ID		02692	06254
Ensembl ID		ENSG00000007968	ENSG00000183955
Uniprot IDs		Q14209	E3VVS3 Q9NQR1
PDB IDs		1N4M	1ZKK 2BQZ 3F9W 3F9X 3F9Y 3F9Z 4IJ8 5HQ2 5T5G 5TEG 5TH7 5V2N 5W1Y 6BOZ 7D1Z 7D20 7XPX
Enriched GO Terms of Interacting Partners?		Positive Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of RNA Biosynthetic Process Chromatin Nucleoplasm Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Rb-E2F Complex Regulation Of Cell Cycle Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Chromatin Organization G1/S Transition Of Mitotic Cell Cycle Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Transcription Corepressor Activity Regulation Of Voltage-gated Calcium Channel Activity Ino80 Complex Positive Regulation Of Telomere Maintenance In Response To DNA Damage Cell Cycle G1/S Phase Transition Regulation Of DNA Strand Elongation Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Cell Division Positive Regulation Of Biosynthetic Process Transcription Regulator Complex Transcription Factor Binding Protein Localization To Chromosome DNA Damage Response PcG Protein Complex Transcription Coregulator Activity Positive Regulation Of Metabolic Process BHLH Transcription Factor Binding Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Mitotic Cell Cycle Phase Transition Regulation Of Macromolecule Metabolic Process Chromosome Organization Cell Cycle Phase Transition Positive Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Guanyl-nucleotide Exchange Factor Adaptor Activity Regulation Of G1/S Transition Of Mitotic Cell Cycle	Nucleoplasm Nucleus Negative Regulation Of DNA-templated Transcription Rhythmic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Chromosome Organization Signal Transduction In Response To DNA Damage Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Chromosome, Telomeric Region DNA Metabolic Process Negative Regulation Of Biosynthetic Process Response To Radiation Regulation Of DNA Repair Chromatin Organization Post-translational Protein Modification Protein K63-linked Ubiquitination Regulation Of DNA Metabolic Process Cis-regulatory Region Sequence-specific DNA Binding DNA Repair Negative Regulation Of Macromolecule Metabolic Process Regulation Of Cellular Response To Stress Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Site Of Double-strand Break DNA Damage Checkpoint Signaling Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Polyubiquitination Protein Localization To Chromosome PML Body CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Negative Regulation Of Megakaryocyte Differentiation Regulation Of Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Chromatin Remodeling Lymphocyte Activation Involved In Immune Response Telomere Organization Proteolysis Involved In Protein Catabolic Process Regulation Of Primary Metabolic Process Protein Modification By Small Protein Conjugation Negative Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of DNA Repair Translesion Synthesis Synaptonemal Complex
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