E2F2 and CCNF

Number of citations of the paper that reports this interaction (PubMedID 36607545)
0

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		E2F2	CCNF
Description		E2F transcription factor 2	cyclin F
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Rb-E2F Complex RNA Polymerase II Transcription Regulator Complex	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Cytoplasm Centrosome Centriole Microtubule Organizing Center Cytosol Cytoskeleton SCF Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding	Protein Binding Anaphase-promoting Complex Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Sprouting Angiogenesis Lens Fiber Cell Apoptotic Process	G1/S Transition Of Mitotic Cell Cycle Re-entry Into Mitotic Cell Cycle Placenta Development Negative Regulation Of Centrosome Duplication Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Division Regulation Of Cell Cycle
Pathways		Oxidative Stress Induced Senescence Oncogene Induced Senescence Cyclin D associated events in G1 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Eosinophil count ( 27863252 32888494) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Lymphocyte count ( 32888494) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 28957414 27863252 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Severe insulin-resistant type 2 diabetes ( 34737425) Sum eosinophil basophil counts ( 27863252) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494 27863252)	Height ( 28552196) Triglyceride levels ( 32203549)
Interacting Genes		20 interacting genes: ARID3A ATAD2 BCAR1 BRD2 CCNF CDK3 FHL2 GIT2 GNB5 GRB2 KMT5A RB1 RNF144A RYBP SP1 SPIB TFDP1 TFDP2 UCHL5 YY1	10 interacting genes: AKT1 CCNB1 E2F1 E2F2 E2F3 FZR1 MYBL2 RBPJ SCYL1 SQSTM1
Entrez ID		1870	899
HPRD ID		02692	02574
Ensembl ID		ENSG00000007968	ENSG00000162063
Uniprot IDs		Q14209	P41002 Q59HD0
PDB IDs		1N4M	9CB3
Enriched GO Terms of Interacting Partners?		Positive Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of RNA Biosynthetic Process Chromatin Nucleoplasm Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Rb-E2F Complex Regulation Of Cell Cycle Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Chromatin Organization G1/S Transition Of Mitotic Cell Cycle Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Transcription Corepressor Activity Regulation Of Voltage-gated Calcium Channel Activity Ino80 Complex Positive Regulation Of Telomere Maintenance In Response To DNA Damage Cell Cycle G1/S Phase Transition Regulation Of DNA Strand Elongation Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Cell Division Positive Regulation Of Biosynthetic Process Transcription Regulator Complex Transcription Factor Binding Protein Localization To Chromosome DNA Damage Response PcG Protein Complex Transcription Coregulator Activity Positive Regulation Of Metabolic Process BHLH Transcription Factor Binding Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Mitotic Cell Cycle Phase Transition Regulation Of Macromolecule Metabolic Process Chromosome Organization Cell Cycle Phase Transition Positive Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Guanyl-nucleotide Exchange Factor Adaptor Activity Regulation Of G1/S Transition Of Mitotic Cell Cycle	Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Transcription By RNA Polymerase II Lens Fiber Cell Apoptotic Process Positive Regulation Of Organ Growth Negative Regulation Of Fat Cell Proliferation Rb-E2F Complex Positive Regulation Of Metabolic Process Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Cell Population Proliferation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Transcription Regulator Complex Cis-regulatory Region Sequence-specific DNA Binding Nucleoplasm Regulation Of Organ Growth Anoikis Regulation Of Mitotic Cell Cycle Phase Transition Protein Import Into Nucleus Import Into Nucleus Nucleus Regulation Of Generation Of Precursor Metabolites And Energy RNA Polymerase II Transcription Regulator Complex Macromolecule Biosynthetic Process Labyrinthine Layer Blood Vessel Development Cellular Response To Decreased Oxygen Levels Nucleobase-containing Compound Biosynthetic Process Regulation Of RNA Metabolic Process Anaphase-promoting Complex-dependent Catabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Cell Cycle Phase Transition DNA-binding Transcription Activator Activity Cellular Response To Oxygen Levels Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Protein Kinase Binding Positive Regulation Of Developmental Growth Sequence-specific DNA Binding Regulation Of Cell Population Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Protein Localization To Nucleus Regulation Of Mitotic Cell Cycle Placenta Blood Vessel Development Positive Regulation Of Macromolecule Biosynthetic Process Protein Dimerization Activity Regulation Of Protein Ubiquitination
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