TNFAIP6

Name	TNF alpha induced protein 6
Structure
Interactors	3 interactors: ACAN THBS1 UBC
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Fibronectin Binding Calcium Ion Binding Protein Binding Hyaluronic Acid Binding Hydrolase Activity Metal Ion Binding Carboxylesterase Activity
	Biological Process	Ovarian Cumulus Expansion Inflammatory Response Cell Adhesion Signal Transduction Cell-cell Signaling Hyaluronan Metabolic Process Positive Regulation Of Cell Migration Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Osteoclast Differentiation Negative Regulation Of Inflammatory Response Negative Regulation Of Neutrophil Chemotaxis Positive Regulation Of Receptor Clustering Fibronectin Fibril Organization
Pathways	Neutrophil degranulation
Drugs	Donepezil Acetylsalicylic acid Hyaluronic acid
GWAS	Blood protein levels ( 30072576 ) Lung cancer ( 23143601 )
Entrez ID	7130
HPRD ID	02680
Ensembl ID	ENSG00000123610
Uniprot IDs	P98066
PDB IDs	1O7B 1O7C 2N40 2PF5 2WNO
GO Terms Enriched among Interactors ?	Extracellular Matrix Structural Constituent Conferring Compression Resistance Extracellular Matrix Perineuronal Net Extracellular Space Extracellular Matrix Structural Constituent Negative Regulation Of Endothelial Cell Chemotaxis Negative Regulation Of Dendritic Cell Antigen Processing And Presentation Negative Regulation Of Plasminogen Activation Negative Regulation Of Fibrinolysis Negative Regulation Of Nitric Oxide Mediated Signal Transduction Nitric Oxide-cGMP-mediated Signaling Chronic Inflammatory Response Negative Regulation Of Antigen Processing And Presentation Negative Regulation Of Fatty Acid Transport Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Collagen V Binding Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Transforming Growth Factor Beta1 Production Blood Coagulation, Fibrin Clot Formation Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Negative Regulation Of Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Regulation Of CGMP-mediated Signaling Regulation Of Long-chain Fatty Acid Import Into Cell Fibrinogen Binding Fibrinogen Complex Proteoglycan Binding Engulfment Of Apoptotic Cell Negative Regulation Of CGMP-mediated Signaling Regulation Of Nitric Oxide Mediated Signal Transduction Hyaluronic Acid Binding Regulation Of Antigen Processing And Presentation Low-density Lipoprotein Particle Binding Fibroblast Growth Factor Binding Positive Regulation Of Transforming Growth Factor Beta Production Regulation Of Fibrinolysis Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Transforming Growth Factor Beta Binding Protein Activation Cascade Behavioral Response To Pain Negative Regulation Of Focal Adhesion Assembly Response To Magnesium Ion Positive Regulation Of Endothelial Cell Apoptotic Process Platelet Alpha Granule Laminin Binding Negative Regulation Of Sprouting Angiogenesis Nitric Oxide Mediated Signal Transduction Positive Regulation Of Macrophage Chemotaxis Negative Regulation Of Interleukin-12 Production Positive Regulation Of Fibroblast Migration Regulation Of Plasminogen Activation