ACAN and VCAN

Number of citations of the paper that reports this interaction (PMID 12888576)
21

Data Source:
BioGRID (pull down)

		ACAN	VCAN
Gene Name		aggrecan	versican
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Golgi Lumen Extracellular Matrix Lysosomal Lumen	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Golgi Lumen Membrane Extracellular Matrix Lysosomal Lumen Intracellular Membrane-bounded Organelle
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Hyaluronic Acid Binding Carbohydrate Binding Metal Ion Binding	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Glycosaminoglycan Binding Hyaluronic Acid Binding Carbohydrate Binding
	Biological Process	Skeletal System Development Carbohydrate Metabolic Process Proteolysis Cell Adhesion Pathogenesis Keratan Sulfate Biosynthetic Process Extracellular Matrix Disassembly Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Keratan Sulfate Metabolic Process Keratan Sulfate Catabolic Process Small Molecule Metabolic Process	Skeletal System Development Osteoblast Differentiation Carbohydrate Metabolic Process Cell Adhesion Multicellular Organismal Development Central Nervous System Development Heart Development Cell Recognition Glial Cell Migration Pathogenesis Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Catabolic Process Dermatan Sulfate Biosynthetic Process Small Molecule Metabolic Process
Pathways			MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Heparan sulfate/heparin (HS-GAG) metabolism Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism CS/DS degradation Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective CHST14 causes EDS, musculocontractural type Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora ECM proteoglycans Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D A tetrasaccharide linker sequence is required for GAG synthesis Chondroitin sulfate biosynthesis MPS IIIC - Sanfilippo syndrome C Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A Dermatan sulfate biosynthesis Defective CHSY1 causes TPBS MPS IV - Morquio syndrome B MPS VII - Sly syndrome Metabolism of carbohydrates MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS		Height ( 21998595 20881960 23563607 18391952)	Major depressive disorder ( 20516156)
Protein-Protein Interactions		18 interactors: ADAMTS1 ADAMTS4 ADAMTS5 CTSB FBLN1 FBLN2 HAPLN1 LUM MMP1 MMP14 MMP19 MMP2 MMP20 MMP3 MMP8 TNFAIP6 TNR VCAN	24 interactors: ACAN ADAMTS1 CCL2 CCL20 CCL21 CCL5 CCL8 CD44 CXCL10 CXCL12 CXCR3 FBLN1 FBLN2 FBN1 HAPLN1 ITGA4 ITGB1 PF4 PLA2G2A SELL SELP SELPLG TNR XCL1
Entrez ID		176	1462
HPRD ID		01123	00340
Ensembl ID		ENSG00000157766	ENSG00000038427
Uniprot IDs		E7ENV9 E7EX88	P13611 Q59FG9 Q6MZK8 Q86W61
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Proteolysis Catabolic Process Ovulation Skeletal System Development Multicellular Organismal Development Endodermal Cell Differentiation Endoderm Formation Developmental Process Single Organism Reproductive Process Reproductive Process Anatomical Structure Development Ovulation From Ovarian Follicle Endoderm Development System Development Ovulation Cycle Process Female Gonad Development Female Gamete Generation Ovulation Cycle Development Of Primary Female Sexual Characteristics Positive Regulation Of Protein Oligomerization Protein Metabolic Process Organ Development Formation Of Primary Germ Layer Regulation Of Protein Oligomerization Multicellular Organismal Reproductive Process Multicellular Organism Reproduction Cardiovascular System Development Response To Stress Gastrulation Reproductive Structure Development Reproductive System Development Trabecula Morphogenesis Female Pregnancy Gonad Development Development Of Primary Sexual Characteristics Reproduction Negative Regulation Of Axon Extension Involved In Regeneration Anatomical Structure Formation Involved In Morphogenesis Glycosaminoglycan Catabolic Process Cellular Response To Amino Acid Stimulus Response To Stimulus Glial Cell Migration Ossification	Leukocyte Migration Cell Migration Cell Motility Regulation Of Leukocyte Migration Locomotion Positive Regulation Of Leukocyte Migration Cell Chemotaxis Movement Of Cell Or Subcellular Component Regulation Of Lymphocyte Migration Positive Regulation Of Locomotion Positive Regulation Of T Cell Migration Regulation Of T Cell Migration Positive Regulation Of Chemotaxis Chemotaxis Positive Regulation Of Cell Migration Positive Regulation Of Behavior Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Cell Motility Cell Adhesion Positive Regulation Of Cellular Component Movement Regulation Of Chemotaxis Regulation Of Cell Migration Inflammatory Response Regulation Of Cell Motility Immune System Process Regulation Of Behavior Leukocyte Chemotaxis Regulation Of Locomotion Regulation Of Cellular Component Movement Chemokine-mediated Signaling Pathway Response To Other Organism Extracellular Matrix Organization Extracellular Structure Organization Response To Biotic Stimulus Regulation Of Immune System Process Cellular Extravasation Lymphocyte Migration Response To External Stimulus Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Positive Regulation Of Calcium Ion Transport Leukocyte Cell-cell Adhesion Leukocyte Tethering Or Rolling Single Organismal Cell-cell Adhesion Response To Organic Substance Defense Response Positive Regulation Of Cell Adhesion Lymphocyte Chemotaxis T Cell Migration Cellular Response To Cytokine Stimulus
Tagcloud ?		acoustic bioreactor biot bm butanol chitosan chondrocyte col1a1 col2a1 connected cs csb impacted kpa mathematical mhz paralleled polycarbonate polyurethane porosities propagation scaffold scaffolds seeded served simplified sox supplied us	abundant astrocytes basic bcan cg clustering differentiated diverse embryos enriched fbln2 forebrain foundation functionally glial itih3 mesenchymal ncam1 nervous networks neural nsc nscs ontology regulators rich tnr transcriptomes wnt
Tagcloud (Difference) ?		acoustic bioreactor biot bm butanol chitosan chondrocyte col1a1 col2a1 connected cs csb impacted kpa mathematical mhz paralleled polycarbonate polyurethane porosities propagation scaffold scaffolds seeded served simplified sox supplied us	abundant astrocytes basic bcan cg clustering differentiated diverse embryos enriched fbln2 forebrain foundation functionally glial itih3 mesenchymal ncam1 nervous networks neural nsc nscs ontology regulators rich tnr transcriptomes wnt
Tagcloud (Intersection) ?