DLX4 and LSM3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		DLX4	LSM3
Description		distal-less homeobox 4	LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	P-body Nucleus Nucleoplasm Spliceosomal Complex U6 SnRNP Cytosol U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Precatalytic Spliceosome Catalytic Step 2 Spliceosome Lsm2-8 Complex Lsm1-7-Pat1 Complex Ribonucleoprotein Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	RNA Binding Protein Binding U6 SnRNA 3'-end Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Differentiation Embryonic Skeletal System Development	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing P-body Assembly
Pathways			mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Blond vs. brown/black hair color ( 30531825) Blood urea nitrogen levels ( 29403010) Cognitive decline rate in late mild cognitive impairment ( 26252872) Plasma factor V levels in venous thrombosis (conditioned on rs6027) ( 31271701) Serum alkaline phosphatase levels ( 29403010 33339817 33547301)	Chronotype ( 30696823) Dilated cardiomyopathy ( 33677556) Dilated cardiomyopathy (MTAG) ( 33495596) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Height ( 31562340) Offspring birth weight ( 31043758) PR interval ( 32439900) Red blood cell count ( 32888494)
Interacting Genes		3 interacting genes: DNMT3L LSM3 MAGED1	45 interacting genes: CCND3 CDKN2D CEP95 CNOT7 DDIT4L DLX4 EEF1A1 EIF4EBP2 EIF4G3 EXOSC1 EXOSC5 GDF9 GSTA1 HSPB1 INCA1 KEAP1 KLF3 LSM1 LSM10 LSM12 LSM2 LSM5 LSM6 LSM7 LSM8 NACC1 PIAS1 QKI SF3B2 SH3GLB2 SMN1 SNRPD3 SNRPE SNRPF SNRPG TCL1A TEPSIN THOC5 TRAPPC2B UTP14A WDR77 WDR83 XPC XRN2 YBX1
Entrez ID		1748	27258
HPRD ID		03553	06283
Ensembl ID		ENSG00000108813	ENSG00000170860
Uniprot IDs		Q92988	P62310
PDB IDs			3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9 7ABG 8H6E 8H6J 8H6K 8H6L 8QO9 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5
Enriched GO Terms of Interacting Partners?		Lsm2-8 Complex U6 SnRNP Lsm1-7-Pat1 Complex U6 SnRNA 3'-end Binding Chorionic Trophoblast Cell Differentiation Autosome Genomic Imprinting Epigenetic Programing Of Female Pronucleus Negative Regulation Of DNA Methylation-dependent Heterochromatin Formation Negative Regulation Of Heterochromatin Formation Regulation Of Heterochromatin Formation P-body Assembly Transposable Element Silencing By PiRNA-mediated DNA Methylation Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation ESC/E(Z) Complex Epigenetic Programming In The Zygotic Pronuclei Regulation Of Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Precatalytic Spliceosome Regulatory NcRNA-mediated Heterochromatin Formation Transposable Element Silencing By Heterochromatin Formation Genomic Imprinting Catalytic Complex Regulation Of Chromatin Organization Male Meiosis I Positive Regulation Of Morphogenesis Of An Epithelium Regulation Of Kidney Development U4/U6 X U5 Tri-snRNP Complex Epigenetic Programming Of Gene Expression Transposable Element Silencing Meiosis I DNA Methylation-dependent Constitutive Heterochromatin Formation Placenta Development Negative Regulation Of Protein Localization To Nucleus U2-type Precatalytic Spliceosome Male Meiotic Nuclear Division Condensed Nuclear Chromosome Heterochromatin Regulation Of Morphogenesis Of A Branching Structure Constitutive Heterochromatin Formation	RNA Splicing MRNA Metabolic Process MRNA Processing U2-type Precatalytic Spliceosome RNA Splicing, Via Transesterification Reactions RNA Processing U4/U6 X U5 Tri-snRNP Complex RNA Binding MRNA Splicing, Via Spliceosome U12-type Spliceosomal Complex RNA Metabolic Process Spliceosomal Complex Nucleic Acid Metabolic Process U7 SnRNP Lsm2-8 Complex Precatalytic Spliceosome U6 SnRNP Spliceosomal SnRNP Assembly Catalytic Step 2 Spliceosome Nucleoplasm Methylosome Ribonucleoprotein Complex Lsm1-7-Pat1 Complex Nucleobase-containing Compound Metabolic Process Small Nuclear Ribonucleoprotein Complex SMN-Sm Protein Complex Nucleus MRNA Catabolic Process RNA Catabolic Process Spliceosomal Complex Assembly 7-methylguanosine Cap Hypermethylation U2-type Prespliceosome Assembly U2 SnRNP U2-type Spliceosomal Complex U4 SnRNP Protein-RNA Complex Assembly Cytoplasm Macromolecule Metabolic Process U1 SnRNP U5 SnRNP Nucleobase-containing Compound Catabolic Process PICln-Sm Protein Complex Spliceosomal Tri-snRNP Complex U2-type Catalytic Step 2 Spliceosome U6 SnRNA Binding P-body RNA Exonuclease Activity Nuclear-transcribed MRNA Catabolic Process Cytosol U7 SnRNA Binding
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