COMMD6 and USP40

Number of citations of the paper that reports this interaction (PubMedID 35605301)
0

Data Source:
BioGRID (two hybrid)

		COMMD6	USP40
Description		COMM domain containing 6	ubiquitin specific peptidase 40
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Cytosol
	Molecular Function	Protein Binding NF-kappaB Binding	Cysteine-type Deubiquitinase Activity Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity
	Biological Process	Signal Transduction Negative Regulation Of NF-kappaB Transcription Factor Activity	Proteolysis Protein Deubiquitination Regulation Of Protein Stability
Pathways		Neddylation
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Diabetic retinopathy ( 23562823) Metabolite levels ( 23823483) Red blood cell count ( 29403010)	Bilirubin levels ( 21646302 31319653 31801373 32084209) Crohn's disease ( 22412388) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Femur bone mineral density x serum urate levels interaction ( 34046847) Hair greying ( 26926045)
Interacting Genes		3 interacting genes: COMMD1 HSPA6 USP40	45 interacting genes: A2M ACSF2 ADH5 AHSA1 ALDOB APOM C1QA CLN8 COMMD6 DDB1 DDB2 EEF1A1 EEF1D EPB41L1 HCG11 HEBP2 HINT1 HSPA8 IL11RA ITGA6 LDHB LRP2 MT2A MTRNR2L1 NORAD OCLN OS9 PMS2P1 PSTK RACK1 RNF7 RPL30 RPS18 RPS20 RPS3A SLC12A1 SLC2A5 SRSF2 STT3A TCF25 TOMM20 TPT1 TRAPPC8 UBC VAPA
Entrez ID		170622	55230
HPRD ID		13084	07166
Ensembl ID		ENSG00000188243	ENSG00000085982
Uniprot IDs		Q7Z4G1	A0A7I2YQ75 C9JK14 Q9NVE5
PDB IDs		8F2R 8F2U 8P0W
Enriched GO Terms of Interacting Partners?		L-allo-threonine Aldolase Activity Protein Deubiquitination Protein Modification By Small Protein Removal Glycine Hydroxymethyltransferase Activity Glycine Biosynthetic Process From Serine Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Ubiquitination Negative Regulation Of Hypoxia-inducible Factor-1alpha Signaling Pathway Positive Regulation Of Cholesterol Import Formate Biosynthetic Process Positive Regulation Of Endosome To Plasma Membrane Protein Transport Cellular Heat Acclimation Glycine Biosynthetic Process Post-translational Protein Modification BRISC Complex Formate Metabolic Process L-serine Biosynthetic Process Regulation Of Protein Ubiquitination Regulation Of Cholesterol Import Regulation Of Plasma Lipoprotein Particle Levels Regulation Of Post-translational Protein Modification Branchiomotor Neuron Axon Guidance Microtubule Cytoskeleton Sodium Channel Inhibitor Activity Positive Regulation Of Endocytic Recycling Negative Regulation Of Sodium Ion Transmembrane Transport Tetrahydrofolate Interconversion Regulation Of Synaptic Assembly At Neuromuscular Junction Plasma Membrane To Endosome Transport Glycine Metabolic Process Response To Type I Interferon Intracellular Organelle Lumen Amino Acid Binding Regulation Of Axon Guidance Negative Regulation Of Cellular Response To Hypoxia Negative Regulation Of Protein Localization To Cell Surface L-serine Metabolic Process Negative Regulation Of Sodium Ion Transport Positive Regulation Of Protein Modification Process Regulation Of Protein Catabolic Process Regulation Of Protein Stability Low-density Lipoprotein Particle Clearance Tetrahydrofolate Metabolic Process Cul2-RING Ubiquitin Ligase Complex Copper Ion Homeostasis Positive Regulation Of Protein Localization To Cell Surface Regulation Of Mitochondrial Translation Regulation Of Endocytic Recycling Regulation Of Protein Metabolic Process Regulation Of Oxidative Phosphorylation	Extracellular Exosome Translation Cytosolic Small Ribosomal Subunit Cytosolic Ribosome Ribosome Cytoplasmic Translation Translational Elongation Eukaryotic Translation Elongation Factor 1 Complex Small Ribosomal Subunit Cul4B-RING E3 Ubiquitin Ligase Complex Fructose Binding Cadherin Binding Protein Metabolic Process Host-mediated Activation Of Viral Genome Replication UV-damage Excision Repair Host-mediated Perturbation Of Viral Genome Replication Ribonucleoprotein Complex Insulin-like Growth Factor I Binding Response To Redox State Cul4A-RING E3 Ubiquitin Ligase Complex Import Across Plasma Membrane Structural Constituent Of Ribosome
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?