COMMD6

Description		COMM domain containing 6
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GO Annotations	Cellular Component	Nucleus Cytoplasm
	Molecular Function	Protein Binding NF-kappaB Binding
	Biological Process	Signal Transduction Negative Regulation Of NF-kappaB Transcription Factor Activity
Pathways		Neddylation
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Diabetic retinopathy ( 23562823) Metabolite levels ( 23823483) Red blood cell count ( 29403010)
Novel Interacting Genes		2 novel interacting genes: MYCBP2 SHMT2
Interacting Genes		3 interacting genes: COMMD1 HSPA6 USP40
Entrez ID		170622
HPRD ID		13084
Ensembl ID		ENSG00000188243
Uniprot IDs		Q7Z4G1
PDB IDs		8F2R 8F2U 8P0W
Enriched GO Terms of Interacting Partners?		L-allo-threonine Aldolase Activity Protein Deubiquitination Protein Modification By Small Protein Removal Glycine Hydroxymethyltransferase Activity Glycine Biosynthetic Process From Serine Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Ubiquitination Negative Regulation Of Hypoxia-inducible Factor-1alpha Signaling Pathway Positive Regulation Of Cholesterol Import Formate Biosynthetic Process Positive Regulation Of Endosome To Plasma Membrane Protein Transport Cellular Heat Acclimation Glycine Biosynthetic Process Post-translational Protein Modification BRISC Complex Formate Metabolic Process L-serine Biosynthetic Process Regulation Of Protein Ubiquitination Regulation Of Cholesterol Import Regulation Of Plasma Lipoprotein Particle Levels Regulation Of Post-translational Protein Modification Branchiomotor Neuron Axon Guidance Microtubule Cytoskeleton Sodium Channel Inhibitor Activity Positive Regulation Of Endocytic Recycling Negative Regulation Of Sodium Ion Transmembrane Transport Tetrahydrofolate Interconversion Regulation Of Synaptic Assembly At Neuromuscular Junction Plasma Membrane To Endosome Transport Glycine Metabolic Process Response To Type I Interferon Intracellular Organelle Lumen Amino Acid Binding Regulation Of Axon Guidance Negative Regulation Of Cellular Response To Hypoxia Negative Regulation Of Protein Localization To Cell Surface L-serine Metabolic Process Negative Regulation Of Sodium Ion Transport Positive Regulation Of Protein Modification Process Regulation Of Protein Catabolic Process Regulation Of Protein Stability Low-density Lipoprotein Particle Clearance Tetrahydrofolate Metabolic Process Cul2-RING Ubiquitin Ligase Complex Copper Ion Homeostasis Positive Regulation Of Protein Localization To Cell Surface Regulation Of Mitochondrial Translation Regulation Of Endocytic Recycling Regulation Of Protein Metabolic Process Regulation Of Oxidative Phosphorylation
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