DCT and PLP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DCT	PLP1
Description		dopachrome tautomerase	proteolipid protein 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Melanosome Membrane Melanosome	Plasma Membrane Membrane Myelin Sheath Synapse
	Molecular Function	Dopachrome Isomerase Activity Copper Ion Binding Protein Binding Oxidoreductase Activity Isomerase Activity Metal Ion Binding	Structural Molecule Activity Protein Binding Structural Constituent Of Myelin Sheath Identical Protein Binding
	Biological Process	Positive Regulation Of Neuroblast Proliferation Melanin Biosynthetic Process From Tyrosine Neuroblast Proliferation Epidermis Development Response To Blue Light Ventricular Zone Neuroblast Division Melanin Biosynthetic Process Pigmentation Developmental Pigmentation Cell Development	Inflammatory Response Chemical Synaptic Transmission Axon Ensheathment Positive Regulation Of Gene Expression Astrocyte Development Substantia Nigra Development Central Nervous System Myelination Myelination Long-chain Fatty Acid Biosynthetic Process Axon Development
Pathways		Melanin biosynthesis Regulation of MITF-M-dependent genes involved in pigmentation
Drugs
Diseases			Hypomyelinating leukodystrophy (HLD); Pelizaeus-Merzbacher disease (PMD) Hereditary spastic paraplegia (SPG)
GWAS		Blond vs. brown/black hair color ( 30531825) Hair color ( 29662168) Low tan response ( 29739929) Night sleep phenotypes ( 27126917) Pelvic organ prolapse ( 26545240)
Interacting Genes		1 interacting genes: PLP1	91 interacting genes: ADGRG3 AKT1 AQP10 AQP6 ARL13B BCL2L13 BIK CALN1 CALR CANX CD40 CD74 CDIPT CLDN2 CLDN20 CLEC2D CLN8 CREB3 CREB3L1 CYB5R3 CYBC1 DCT DYRK1A DYSF EDA2R ELOVL4 ERGIC3 FAM209A FCRL2 FFAR2 FKBP7 FNDC9 GAST GJA8 GPR42 GPR61 HAS3 HTR2C IER3IP1 IFITM3 ITGAV JAGN1 JPH1 KLRC1 LEPROTL1 LEUTX LHFPL5 LMNA MAG MBP MFF MGST3 MS4A3 MS4A4A MTIF3 MUC1 MYADM NRG1 PI16 PIGP PTPRN RELL2 RMDN3 RNF24 SLC10A6 SLC16A2 SLC18A1 SLC1A5 SLC26A6 SLC35E2A SLC35E3 SLC35H1 SLC41A3 SMIM3 SPNS3 STX1A STX4 SUSD3 TMEM106C TMEM14B TMEM182 TMEM242 TMEM243 TMEM254 TMEM31 TMEM45B TMEM52B TMEM97 TMPRSS2 UPK2 VAT1
Entrez ID		1638	5354
HPRD ID		01864	02321
Ensembl ID		ENSG00000080166	ENSG00000123560
Uniprot IDs		P40126	A0A0S2Z4D4 A8K9L3 B4DI30 P60201
PDB IDs		4HX1	2XPG
Enriched GO Terms of Interacting Partners?		Positive Regulation Of L-glutamate Import Across Plasma Membrane Sequestering Of Calcium Ion Synaptic Vesicle Targeting Protein Catabolic Process At Postsynapse Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Amyloid Fibril Formation Cajal-Retzius Cell Differentiation Negative Regulation Of Core Promoter Binding Growth Factor Receptor Binding Negative Regulation Of Transcription Regulatory Region DNA Binding Astrocyte Activation Involved In Immune Response Cell Development Plasma Membrane Bounded Cell Projection Organization Structural Constituent Of Myelin Sheath Astrocyte Development Central Nervous System Myelination Skin Morphogenesis Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of L-glutamate Import Across Plasma Membrane Amyloid Precursor Protein Catabolic Process Vesicle Targeting Myeloid Dendritic Cell Differentiation Regulation Of Receptor Recycling Membrane Protein Ectodomain Proteolysis Positive Regulation Of Receptor Recycling Neuron Projection Maintenance Regulation Of Amyloid Fibril Formation Brain Morphogenesis Smooth Endoplasmic Reticulum L-glutamate Import Across Plasma Membrane Amyloid-beta Metabolic Process Regulation Of Synaptic Vesicle Cycle Choline Transport Negative Regulation Of DNA Binding Ciliary Rootlet Amyloid-beta Formation Astrocyte Activation Regulation Of Resting Membrane Potential Gamma-secretase Complex Positive Regulation Of Amino Acid Transport Notch Receptor Processing Aspartic Endopeptidase Activity, Intramembrane Cleaving Dorsal/ventral Neural Tube Patterning Positive Regulation Of Glycolytic Process Aspartic-type Endopeptidase Activity Regulation Of Transcription Regulatory Region DNA Binding Amyloid Precursor Protein Metabolic Process Neural Retina Development Cerebral Cortex Neuron Differentiation Synapse	Membrane Protein Binding Plasma Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Transmembrane Transport Negative Regulation Of Apoptotic Signaling Pathway Compact Myelin Antiporter Activity
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