DCT

Description		dopachrome tautomerase
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Melanosome Membrane Melanosome
	Molecular Function	Dopachrome Isomerase Activity Copper Ion Binding Protein Binding Oxidoreductase Activity Isomerase Activity Metal Ion Binding
	Biological Process	Positive Regulation Of Neuroblast Proliferation Melanin Biosynthetic Process From Tyrosine Neuroblast Proliferation Epidermis Development Response To Blue Light Ventricular Zone Neuroblast Division Melanin Biosynthetic Process Pigmentation Developmental Pigmentation Cell Development
Pathways		Melanin biosynthesis Regulation of MITF-M-dependent genes involved in pigmentation
Drugs
Diseases
GWAS		Blond vs. brown/black hair color ( 30531825) Hair color ( 29662168) Low tan response ( 29739929) Night sleep phenotypes ( 27126917) Pelvic organ prolapse ( 26545240)
Novel Interacting Genes		1 novel interacting genes: PSEN1
Interacting Genes		1 interacting genes: PLP1
Entrez ID		1638
HPRD ID		01864
Ensembl ID		ENSG00000080166
Uniprot IDs		P40126
PDB IDs		4HX1
Enriched GO Terms of Interacting Partners?		Positive Regulation Of L-glutamate Import Across Plasma Membrane Sequestering Of Calcium Ion Synaptic Vesicle Targeting Protein Catabolic Process At Postsynapse Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Amyloid Fibril Formation Cajal-Retzius Cell Differentiation Negative Regulation Of Core Promoter Binding Growth Factor Receptor Binding Negative Regulation Of Transcription Regulatory Region DNA Binding Astrocyte Activation Involved In Immune Response Cell Development Plasma Membrane Bounded Cell Projection Organization Structural Constituent Of Myelin Sheath Astrocyte Development Central Nervous System Myelination Skin Morphogenesis Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of L-glutamate Import Across Plasma Membrane Amyloid Precursor Protein Catabolic Process Vesicle Targeting Myeloid Dendritic Cell Differentiation Regulation Of Receptor Recycling Membrane Protein Ectodomain Proteolysis Positive Regulation Of Receptor Recycling Neuron Projection Maintenance Regulation Of Amyloid Fibril Formation Brain Morphogenesis Smooth Endoplasmic Reticulum L-glutamate Import Across Plasma Membrane Amyloid-beta Metabolic Process Regulation Of Synaptic Vesicle Cycle Choline Transport Negative Regulation Of DNA Binding Ciliary Rootlet Amyloid-beta Formation Astrocyte Activation Regulation Of Resting Membrane Potential Gamma-secretase Complex Positive Regulation Of Amino Acid Transport Notch Receptor Processing Aspartic Endopeptidase Activity, Intramembrane Cleaving Dorsal/ventral Neural Tube Patterning Positive Regulation Of Glycolytic Process Aspartic-type Endopeptidase Activity Regulation Of Transcription Regulatory Region DNA Binding Amyloid Precursor Protein Metabolic Process Neural Retina Development Cerebral Cortex Neuron Differentiation Synapse
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