SASS6 and FCHSD2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SASS6	FCHSD2
Description		SAS-6 centriolar assembly protein	FCH and double SH3 domains 2
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GO Annotations	Cellular Component	Cytoplasm Centrosome Centriole Cytoskeleton Deuterosome Procentriole Replication Complex	Cytoplasm Plasma Membrane Clathrin-coated Pit Membrane Neuromuscular Junction Stereocilium Cell Projection Recycling Endosome Anchoring Junction Stereocilium Shaft
	Molecular Function	Protein Binding	Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Lipid Binding Phosphatidylinositol-3,4-bisphosphate Binding
	Biological Process	Centriole Replication Spermatogenesis Positive Regulation Of Centriole Replication Centrosome Duplication Regulation Of Mitotic Spindle Organization Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Spindle Assembly	Endocytosis Neuromuscular Synaptic Transmission Protein Transport Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Cytoskeleton Organization Membrane Organization Clathrin-dependent Endocytosis Regulation Of Actin Filament Organization Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways
Drugs
Diseases
GWAS		Adiponectin levels ( 33562295)	Albumin-globulin ratio ( 29403010) Crohn's disease ( 23266558 23850713) Endometrial cancer (endometrioid histology) ( 30093612) Health literacy ( 31250787) Nicotine dependence symptom count ( 25555482) Serum total protein levels ( 29403010) Systemic lupus erythematosus ( 26663301 33272962)
Interacting Genes		3 interacting genes: FBXW5 FCHSD2 FZR1	52 interacting genes: ABCF3 ACAP1 ANKS1A ATPAF2 BORCS6 C9orf78 CASK CCDC120 CCDC158 CCDC183 CCDC85B CCT2 CFAP36 CHKA CIMIP6 CTAG1A CTAG1B DAPP1 ENKD1 FAM9B GPRASP2 HDAC4 HGS HOMER1 HSP90AB1 HSPA5 HTRA1 ITSN1 ITSN2 KIFC3 LCA5L LDOC1 MNS1 MRFAP1 MSL1 MTUS2 PDE4DIP PRKAR1B RINT1 SASS6 SERTAD3 SH2D4A SH3BGR SRP72 TLE5 TSGA10IP USHBP1 VCPIP1 VPS37C WAS WASL ZNF587
Entrez ID		163786	9873
HPRD ID		10907	13321
Ensembl ID		ENSG00000156876	ENSG00000137478
Uniprot IDs		B4DYM7 Q495U0 Q6UVJ0	O94868
PDB IDs		6YS4 6Z4A	2DL5 2DL7 6GBU
Enriched GO Terms of Interacting Partners?		Regulation Of Organelle Organization Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Stereocilium Shaft DNA Synthesis Involved In Mitotic DNA Replication Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Anaphase-promoting Complex Binding Thymidine Metabolic Process Ubiquitin-protein Transferase Activator Activity Thymidine Biosynthetic Process Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Regulation Of Nuclear Division Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Ubiquitin Protein Ligase Activity Positive Regulation Of Actin Nucleation Pyrimidine Nucleoside Metabolic Process Ubiquitin Ligase Activator Activity Proteasomal Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Mitotic Cell Cycle Lens Fiber Cell Differentiation Regulation Of Cellular Component Organization Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Anaphase-promoting Complex Protein Ubiquitination Phosphatidylinositol-3,4-bisphosphate Binding Regulation Of Arp2/3 Complex-mediated Actin Nucleation Anaphase-promoting Complex-dependent Catabolic Process Proteolysis Involved In Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Protein Modification By Small Protein Conjugation Negative Regulation Of Cellular Senescence Cul4-RING E3 Ubiquitin Ligase Complex Neuromuscular Synaptic Transmission Clathrin-dependent Endocytosis Regulation Of Cell Cycle Process Regulation Of Meiotic Nuclear Division Regulation Of Actin Nucleation Mitotic G2 DNA Damage Checkpoint Signaling Phosphatidylinositol-3,4,5-trisphosphate Binding Post-translational Protein Modification Protein K11-linked Ubiquitination Pyrimidine-containing Compound Biosynthetic Process Stereocilium Nucleoside Metabolic Process Positive Regulation Of Actin Filament Polymerization Regulation Of Cellular Senescence Regulation Of Centrosome Duplication Mitotic G2/M Transition Checkpoint	TPR Domain Binding Clathrin-dependent Synaptic Vesicle Endocytosis Cytoplasm
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