KANK4 and CUL5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KANK4	CUL5
Description		KN motif and ankyrin repeat domains 4	cullin 5
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Microtubule Cytoskeleton	Nucleus Cytoplasm Cytosol SCF Ubiquitin Ligase Complex Cullin-RING Ubiquitin Ligase Complex Cul5-RING Ubiquitin Ligase Complex Site Of DNA Damage
	Molecular Function	Protein Binding	Ubiquitin-protein Transferase Activity Calcium Channel Activity Protein Binding Protein-macromolecule Adaptor Activity Ubiquitin Protein Ligase Binding Signaling Receptor Activity Ubiquitin Ligase Complex Scaffold Activity
	Biological Process	Negative Regulation Of Actin Filament Polymerization	G1/S Transition Of Mitotic Cell Cycle Epithelial To Mesenchymal Transition Ubiquitin-dependent Protein Catabolic Process Signal Transduction Proteasomal Protein Catabolic Process Negative Regulation Of Epithelial To Mesenchymal Transition Cell Migration Protein Ubiquitination Layer Formation In Cerebral Cortex Positive Regulation Of Cell Migration Endoplasmic Reticulum Unfolded Protein Response SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Reelin-mediated Signaling Pathway ERBB2 Signaling Pathway Erythropoietin-mediated Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Defense Response To Virus Positive Regulation Of Focal Adhesion Assembly Negative Regulation Of Focal Adhesion Assembly Symbiont-mediated Suppression Of Host Innate Immune Response Growth Hormone Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Growth Hormone Receptor Signaling Pathway Calcium Ion Transmembrane Transport Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Focal Adhesion Disassembly CGAS/STING Signaling Pathway Negative Regulation Of CGAS/STING Signaling Pathway Regulation Of Neuron Migration
Pathways			Vif-mediated degradation of APOBEC3G Downregulation of ERBB2 signaling Neddylation Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling Antigen processing: Ubiquitination & Proteasome degradation Evasion by RSV of host interferon responses
Drugs
Diseases
GWAS		Fuchs's corneal dystrophy ( 28358029) Regular attendance at a gym or sports club ( 29970889)	Refractive error ( 32231278)
Interacting Genes		6 interacting genes: CSK CUL5 HAT1 HOMER3 MYLIP TRAPPC6A	41 interacting genes: ANAPC11 APOBEC3C APOBEC3G ASB11 CCNB1IP1 CCNDBP1 CKB COG6 COMMD1 COPS2 COPS3 COPS4 COPS5 COPS6 COPS7A COPS8 DCUN1D1 DEPTOR ELOA ELOC ERCC6 GHR GOLGA2 GPS1 KANK4 PRKACA PTPN5 RBX1 RHOBTB1 RHOBTB2 RHOU RNF7 SMAD2 SMURF1 SOX30 TGFBR1 TRAF6 UBA3 UBC UBE2L3 VHL
Entrez ID		163782	8065
HPRD ID		14109	03444
Ensembl ID		ENSG00000132854	ENSG00000166266
Uniprot IDs		B1ALP6 B3KXJ6 Q5T7N3	Q93034
PDB IDs			3DPL 3DQV 4JGH 4N9F 6V9I 7ONI 8EI2 8FVI 8FVJ
Enriched GO Terms of Interacting Partners?		Regulation Of Low-density Lipoprotein Particle Clearance Negative Regulation Of Low-density Lipoprotein Particle Clearance Negative Regulation Of Lipoprotein Particle Clearance Negative Regulation Of Multicellular Organismal Process Symbiont-mediated Suppression Of Host Innate Immune Response Protein Modification Process Negative Regulation Of Focal Adhesion Disassembly G Protein-coupled Glutamate Receptor Binding Negative Regulation Of Cellular Component Organization Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Golgi To Plasma Membrane Protein Transport Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Cytoplasm Negative Regulation Of Cytokine Production Negative Regulation Of Bone Resorption Protein Kinase A Catalytic Subunit Binding Regulation Of Golgi To Plasma Membrane Protein Transport Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of Cell Adhesion Negative Regulation Of Gene Expression Regulation Of Growth Hormone Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Cul5-RING Ubiquitin Ligase Complex Ubiquitin Ligase Complex Scaffold Activity Negative Regulation Of CGAS/STING Signaling Pathway Erythropoietin-mediated Signaling Pathway Cullin-RING Ubiquitin Ligase Complex Negative Regulation Of Growth Hormone Receptor Signaling Pathway Reelin-mediated Signaling Pathway Ubiquitin-protein Transferase Activity Internal Protein Amino Acid Acetylation Subtelomeric Heterochromatin Formation Histone H4 Acetyltransferase Activity Histone H4K12 Acetyltransferase Activity Negative Regulation Of Calcineurin-NFAT Signaling Cascade G Protein-coupled Glutamate Receptor Signaling Pathway Regulation Of Store-operated Calcium Entry Basal Part Of Cell TRAPP Complex TRAPPIII Protein Complex	Protein Neddylation Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Deneddylation Regulation Of Protein Neddylation Protein Modification Process Regulation Of Post-translational Protein Modification COP9 Signalosome Regulation Of Protein Modification Process Protein Metabolic Process Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Protein Modification By Small Protein Removal Modification-dependent Protein Catabolic Process Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cul5-RING Ubiquitin Ligase Complex Proteolysis Nucleoplasm Cytosol NEDD8 Transferase Activity Cullin Family Protein Binding Macromolecule Catabolic Process Regulation Of Primary Metabolic Process Protein K11-linked Ubiquitination Positive Regulation Of Protein Modification Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Polyubiquitination Nucleus I-SMAD Binding Ubiquitin-ubiquitin Ligase Activity Regulation Of Protein Ubiquitination Ubiquitin Protein Ligase Binding Cul2-RING Ubiquitin Ligase Complex Regulation Of Macromolecule Metabolic Process Positive Regulation Of Post-translational Protein Modification Proteasomal Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of TORC1 Signaling Elongin Complex Ubiquitin-protein Transferase Activity NEDD8 Ligase Activity COP9 Signalosome Assembly Cytoplasm Endosome Membrane Negative Regulation Of TOR Signaling Phosphocreatine Biosynthetic Process DeNEDDylase Activity Regulation Of Metabolic Process
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