KANK4 and HOMER3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KANK4	HOMER3
Description		KN motif and ankyrin repeat domains 4	homer scaffold protein 3
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Microtubule Cytoskeleton	Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Dendrite Basal Part Of Cell Synapse Glutamatergic Synapse
	Molecular Function	Protein Binding	Protein Binding Protein Domain Specific Binding G Protein-coupled Glutamate Receptor Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Actin Filament Polymerization	Protein Targeting G Protein-coupled Glutamate Receptor Signaling Pathway Negative Regulation Of Interleukin-2 Production Regulation Of Synaptic Transmission, Glutamatergic Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Store-operated Calcium Entry
Pathways			Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases
GWAS		Fuchs's corneal dystrophy ( 28358029) Regular attendance at a gym or sports club ( 29970889)
Interacting Genes		6 interacting genes: CSK CUL5 HAT1 HOMER3 MYLIP TRAPPC6A	90 interacting genes: ABI1 ABI2 ABI3 APP ARL13B C1orf116 C4orf17 CCDC120 CCDC141 CCDC187 CDC37 CDK18 CEBPA CEBPB CFTR CWF19L2 DRC4 DVL3 DYNLL1 DYNLL2 EAF1 EFHC1 EIF3D FAM161B FAM90A1 FAT1 FMR1 FXR1 FXR2 GGN GRM5 HOMER1 HOXB5 INCA1 ITPR1 KANK2 KANK4 KDM1A KRTAP19-7 LHX2 LNX1 LRRC7 LSM14B MDM1 MEOX1 MFAP1 MIA3 MOS MSS51 NEBL NTAQ1 OTX2 PAX6 PAX7 PKN1 PLAAT5 POLI POM121 PPP1R18 PRCC PRR35 PSMA1 PSMA2 PSMC5 PSORS1C2 RBM14 RBM22 RUNX1T1 RYR1 SAXO1 SAXO4 SCNM1 SDCBP SHANK3 SLAIN1 SMR3B SNCA SNRPF SRPK2 TBC1D22B TOX2 TRPC1 TSC1 USP2 WIPF1 ZBTB4 ZNF19 ZNF35 ZNF414 ZNF655
Entrez ID		163782	9454
HPRD ID		14109	07270
Ensembl ID		ENSG00000132854	ENSG00000051128
Uniprot IDs		B1ALP6 B3KXJ6 Q5T7N3	Q9NSC5
PDB IDs			2P8V 3CVF
Enriched GO Terms of Interacting Partners?		Regulation Of Low-density Lipoprotein Particle Clearance Negative Regulation Of Low-density Lipoprotein Particle Clearance Negative Regulation Of Lipoprotein Particle Clearance Negative Regulation Of Multicellular Organismal Process Symbiont-mediated Suppression Of Host Innate Immune Response Protein Modification Process Negative Regulation Of Focal Adhesion Disassembly G Protein-coupled Glutamate Receptor Binding Negative Regulation Of Cellular Component Organization Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Golgi To Plasma Membrane Protein Transport Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Cytoplasm Negative Regulation Of Cytokine Production Negative Regulation Of Bone Resorption Protein Kinase A Catalytic Subunit Binding Regulation Of Golgi To Plasma Membrane Protein Transport Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of Cell Adhesion Negative Regulation Of Gene Expression Regulation Of Growth Hormone Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Cul5-RING Ubiquitin Ligase Complex Ubiquitin Ligase Complex Scaffold Activity Negative Regulation Of CGAS/STING Signaling Pathway Erythropoietin-mediated Signaling Pathway Cullin-RING Ubiquitin Ligase Complex Negative Regulation Of Growth Hormone Receptor Signaling Pathway Reelin-mediated Signaling Pathway Ubiquitin-protein Transferase Activity Internal Protein Amino Acid Acetylation Subtelomeric Heterochromatin Formation Histone H4 Acetyltransferase Activity Histone H4K12 Acetyltransferase Activity Negative Regulation Of Calcineurin-NFAT Signaling Cascade G Protein-coupled Glutamate Receptor Signaling Pathway Regulation Of Store-operated Calcium Entry Basal Part Of Cell TRAPP Complex TRAPPIII Protein Complex	Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Neuronal Synaptic Plasticity Protein Binding Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Dendritic Spine Cytoplasm Postsynapse Actin-based Cell Projection Postsynaptic Density SCAR Complex C/EBP Complex HMG Box Domain Binding Signaling Adaptor Activity Neuron Projection Growth Cone Filopodium CHOP-C/EBP Complex Cytoplasmic Ribonucleoprotein Granule Filopodium Tip Growth Cone Regulation Of Synaptic Plasticity Translation Regulator Activity Protein Tetramerization Glutamate Receptor Signaling Pathway Negative Regulation Of Cytoskeleton Organization Positive Regulation Of Neurogenesis Cytoskeleton Cytoskeletal Anchor Activity Regulation Of Cytosolic Calcium Ion Concentration RNA Strand Annealing Activity Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway Synapse Organization Telencephalon Regionalization Dorsal/ventral Pattern Formation Regulation Of Nervous System Process Regulation Of Cytoskeleton Organization Regulation Of Nervous System Development Intracellular Membraneless Organelle Scaffold Protein Binding Negative Regulation Of Centriole Replication Positive Regulation Of Nervous System Development Regulation Of Synaptic Transmission, Glutamatergic 14-3-3 Protein Binding RNA Splicing Regulation Of Neurogenesis MRNA Splicing, Via Spliceosome Proteasome Core Complex, Alpha-subunit Complex Neuron Spine Regulation Of Cell Projection Organization Developmental Maturation
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