KANK4 and HAT1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KANK4	HAT1
Description		KN motif and ankyrin repeat domains 4	histone acetyltransferase 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Microtubule Cytoskeleton	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Cytoplasm Mitochondrion Nuclear Matrix Protein-containing Complex
	Molecular Function	Protein Binding	Histone Acetyltransferase Activity Protein Binding Histone H4 Acetyltransferase Activity Transferase Activity Acyltransferase Activity Histone Binding Histone H4K12 Acetyltransferase Activity Protein-lysine-acetyltransferase Activity
	Biological Process	Negative Regulation Of Actin Filament Polymerization	Chromatin Organization Nucleosome Assembly Internal Protein Amino Acid Acetylation Subtelomeric Heterochromatin Formation Chromosome Organization
Pathways			HATs acetylate histones
Drugs
Diseases
GWAS		Fuchs's corneal dystrophy ( 28358029) Regular attendance at a gym or sports club ( 29970889)	Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Myopia ( 27182965) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		6 interacting genes: CSK CUL5 HAT1 HOMER3 MYLIP TRAPPC6A	23 interacting genes: ACAA1 CEBPA EZH2 H2AC20 H3-4 H3C1 H4C14 H4C16 HTR2B KANK4 MEOX2 MORN5 PRKAA2 REL SMAD7 SNAPC1 STEEP1 TCF4 TEPSIN TNFAIP1 TRIB3 YWHAQ ZSCAN4
Entrez ID		163782	8520
HPRD ID		14109	04339
Ensembl ID		ENSG00000132854	ENSG00000128708
Uniprot IDs		B1ALP6 B3KXJ6 Q5T7N3	A0AAG2UVM1 O14929
PDB IDs			2P0W 6VO5 9MJG
Enriched GO Terms of Interacting Partners?		Regulation Of Low-density Lipoprotein Particle Clearance Negative Regulation Of Low-density Lipoprotein Particle Clearance Negative Regulation Of Lipoprotein Particle Clearance Negative Regulation Of Multicellular Organismal Process Symbiont-mediated Suppression Of Host Innate Immune Response Protein Modification Process Negative Regulation Of Focal Adhesion Disassembly G Protein-coupled Glutamate Receptor Binding Negative Regulation Of Cellular Component Organization Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Golgi To Plasma Membrane Protein Transport Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Cytoplasm Negative Regulation Of Cytokine Production Negative Regulation Of Bone Resorption Protein Kinase A Catalytic Subunit Binding Regulation Of Golgi To Plasma Membrane Protein Transport Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of Cell Adhesion Negative Regulation Of Gene Expression Regulation Of Growth Hormone Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Cul5-RING Ubiquitin Ligase Complex Ubiquitin Ligase Complex Scaffold Activity Negative Regulation Of CGAS/STING Signaling Pathway Erythropoietin-mediated Signaling Pathway Cullin-RING Ubiquitin Ligase Complex Negative Regulation Of Growth Hormone Receptor Signaling Pathway Reelin-mediated Signaling Pathway Ubiquitin-protein Transferase Activity Internal Protein Amino Acid Acetylation Subtelomeric Heterochromatin Formation Histone H4 Acetyltransferase Activity Histone H4K12 Acetyltransferase Activity Negative Regulation Of Calcineurin-NFAT Signaling Cascade G Protein-coupled Glutamate Receptor Signaling Pathway Regulation Of Store-operated Calcium Entry Basal Part Of Cell TRAPP Complex TRAPPIII Protein Complex	Structural Constituent Of Chromatin Protein Heterodimerization Activity Nucleosome Chromosome, Telomeric Region Protein-DNA Complex Assembly DNA Binding Nucleosome Assembly Negative Regulation Of Chondrocyte Proliferation Negative Regulation Of Cell Differentiation Sequence-specific DNA Binding Chromatin Remodeling Chromosome Nucleosome Organization Telomere Organization Protein Localization To Chromatin Chromatin Organization Regulation Of Cell Differentiation Nucleus Nucleoplasm Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Developmental Process CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Negative Regulation Of Megakaryocyte Differentiation Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Stem Cell Differentiation Regulation Of Macromolecule Metabolic Process Protein Localization To Chromosome Protein-containing Complex Cardiac Muscle Hypertrophy Positive Regulation Of Proteasomal Protein Catabolic Process Muscle Hypertrophy Regulation Of Cell Development Positive Regulation Of Cartilage Development Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Metabolic Process Acetate CoA-transferase Activity Phenylacetate Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Hepatocyte Homeostasis Beta-catenin Destruction Complex Disassembly Positive Regulation Of Chondrocyte Hypertrophy Chromosome Organization Protein Localization To Chromosome, Centromeric Region Regulation Of Megakaryocyte Differentiation Coated Vesicle Membrane
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