ZNF497 and PTPN21

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZNF497	PTPN21
Description		zinc finger protein 497	protein tyrosine phosphatase non-receptor type 21
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Cytoplasm Cytoskeleton
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription	Protein Dephosphorylation
Pathways
Drugs
Diseases
GWAS			Prudent dietary pattern ( 28644415) Suicidality in mood disorders ( 33783297) Suicide attempt severity in mood disorders ( 33783297)
Interacting Genes		39 interacting genes: CCDC136 CYSRT1 DVL3 GGA3 GOLGA6L9 HOOK2 KHDRBS2 KRTAP1-1 KRTAP1-3 KRTAP10-8 KRTAP10-9 KRTAP12-2 KRTAP12-3 KRTAP4-12 KRTAP4-4 KRTAP6-3 KRTAP9-3 MCC MDFI MID2 MTUS2 NBPF19 NOTCH2NLA OSBPL3 PICK1 PTPN21 PURB SULT2B1 TNS2 TRIM41 VWC2 ZBTB8A ZNF473 ZNF526 ZNF71 ZNF792 ZNF835 ZNF837 ZRANB1	27 interacting genes: AKAP1 ATOSB BAG3 BMX CATSPER1 CWC22 ERBB4 FBXO17 GOLGA2 KIF1C MAGOHB MOB3C NEK6 NSMF PAK5 PARD6A PIBF1 QARS1 RASD1 SNX18 SRC TEC TRIM14 UBASH3B VPS26C YAP1 ZNF497
Entrez ID		162968	11099
HPRD ID		15806	04468
Ensembl ID		ENSG00000174586	ENSG00000070778
Uniprot IDs		Q6ZNH5	Q16825
PDB IDs			8GVL 8GVV 8GWH 8GXE 8Y8Y
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament	Protein Phosphorylation Cardiac Muscle Tissue Regeneration Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity Phosphorylation Protein Autophosphorylation Peptidyl-tyrosine Phosphorylation Centriolar Satellite Tissue Regeneration Intestinal Epithelial Cell Development Protein Kinase Activity U2-type Catalytic Step 1 Spliceosome Microtubule-based Process Columnar/cuboidal Epithelial Cell Development Interleukin-6-mediated Signaling Pathway Cytoskeleton Kinase Activity Establishment Of Planar Polarity Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein ERBB2 Signaling Pathway Mitotic Spindle Organization Spindle Assembly Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Polarized Epithelial Cell Differentiation Positive Regulation Of Protein Localization Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Cardiac Muscle Cell Proliferation
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