DAZL and PUM2

Number of citations of the paper that reports this interaction (PubMedID 12511597)
35

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		DAZL	PUM2
Description		deleted in azoospermia like	pumilio RNA binding family member 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Ribosome Protein-containing Complex	Cytoplasm Cytosol Cytoplasmic Stress Granule Nuclear Membrane Neuronal Cell Body Perinuclear Region Of Cytoplasm Postsynapse Glutamatergic Synapse
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA 3'-UTR Binding Protein Binding Translation Activator Activity Identical Protein Binding	RNA Binding MRNA 3'-UTR Binding Protein Binding MiRNA Binding Pumilio-response Element Binding LncRNA Binding
	Biological Process	Oocyte Maturation Regulation Of Translation Female Meiosis II Germ Cell Development Spermatogenesis Cell Differentiation Positive Regulation Of Meiotic Nuclear Division Positive Regulation Of Translational Initiation 3'-UTR-mediated MRNA Stabilization	Skeletal System Development Hair Follicle Development Regulation Of Translation Mitochondrion Organization Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Respiratory Electron Transport Chain Stress Granule Assembly MiRNA Processing Regulation Of MRNA Stability Positive Regulation Of Sprouting Of Injured Axon Chromosome Organization Regulation Of Chromosome Segregation Adipose Tissue Development Regulation Of MiRNA-mediated Gene Silencing 3'-UTR-mediated MRNA Destabilization Regulation Of Postsynapse Assembly Positive Regulation Of RIG-I Signaling Pathway Regulation Of Intracellular MRNA Localization Positive Regulation Of MiRNA-mediated Gene Silencing
Pathways			Neddylation
Drugs
Diseases
GWAS		Feeling fed-up ( 29500382) Intelligence ( 28530673) Lung cancer ( 28604730) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Smoking initiation ( 33082346) Testicular germ cell tumor ( 23666240 25877299 28604728 28604732)	Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Appendicular lean mass ( 33097823) Body mass index ( 28892062) Low density lipoprotein cholesterol levels ( 32154731)
Interacting Genes		5 interacting genes: DAZ1 DAZ4 DAZAP1 DAZAP2 PUM2	25 interacting genes: AURKA COPS5 DAZ1 DAZ3 DAZ4 DAZL MED23 MED4 MIR128-2 MIR17 MIR199A1 MIR199A2 MIR214 MIR221 MIR7-1 MIR92A2 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G NANOS1
Entrez ID		1618	23369
HPRD ID		09029	09527
Ensembl ID		ENSG00000092345	ENSG00000055917
Uniprot IDs		A0A140VK77 Q92904	B7ZL34 Q8TB72
PDB IDs			3Q0Q 3Q0R 3Q0S
Enriched GO Terms of Interacting Partners?		MRNA 3'-UTR Binding Regulation Of MRNA Metabolic Process Translation Activator Activity Regulation Of MRNA Stability Regulation Of RNA Stability 3'-UTR-mediated MRNA Stabilization Protein-containing Complex Stress Granule Assembly Positive Regulation Of Translational Initiation Regulation Of Translation MRNA Stabilization Male Gamete Generation Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of MRNA Catabolic Process Spermatogenesis RNA Stabilization RNA Binding Gamete Generation Negative Regulation Of RNA Catabolic Process Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Cytoplasmic Stress Granule Pumilio-response Element Binding Negative Regulation Of MRNA Metabolic Process Nucleic Acid Binding Regulation Of Translational Initiation Post-transcriptional Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Sprouting Of Injured Axon Positive Regulation Of MRNA Metabolic Process Positive Regulation Of Translation Developmental Process Involved In Reproduction Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Intracellular MRNA Localization Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Biological Quality Poly(G) Binding Positive Regulation Of Biosynthetic Process Membraneless Organelle Assembly Positive Regulation Of Axon Regeneration Maternal Placenta Development Regulation Of Macromolecule Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of RIG-I Signaling Pathway Positive Regulation Of MiRNA-mediated Gene Silencing Reproductive Process Negative Regulation Of Catabolic Process Mitogen-activated Protein Kinase Kinase Kinase Binding	RISC Complex MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Post-transcriptional Regulation Of Gene Expression Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of MRNA Stability Regulation Of RNA Stability Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of MRNA Metabolic Process MRNA 3'-UTR Binding Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Translation Activator Activity Regulation Of Translation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway 3'-UTR-mediated MRNA Stabilization Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Extracellular Vesicle MiRNA-mediated Gene Silencing By MRNA Destabilization MRNA Destabilization RNA Destabilization Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Regulation Of Protein Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of Connective Tissue Replacement Positive Regulation Of MRNA Catabolic Process Positive Regulation Of Translational Initiation Regulation Of Blood Vessel Endothelial Cell Migration MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Connective Tissue Replacement Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of MRNA Metabolic Process MRNA Stabilization Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Endothelial Cell Migration Positive Regulation Of Tissue Remodeling Negative Regulation Of MRNA Catabolic Process RNA Stabilization
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