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SPRED1 and RIN1
Number of citations of the paper that reports this interaction (PubMedID
32296183
)
50
Data Source:
BioGRID
(two hybrid)
SPRED1
RIN1
Description
sprouty related EVH1 domain containing 1
Ras and Rab interactor 1
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Caveola
Membrane
Cytoplasmic Vesicle
Cytoplasm
Cytosol
Cytoskeleton
Plasma Membrane
Membrane
Endocytic Vesicle
Molecular Function
Stem Cell Factor Receptor Binding
Protein Binding
Protein Kinase Binding
Phosphatase Binding
Protein Serine/threonine Kinase Inhibitor Activity
Guanyl-nucleotide Exchange Factor Activity
GTPase Activator Activity
Protein Binding
Small GTPase Binding
Biological Process
Regulation Of Signal Transduction
Negative Regulation Of Epithelial To Mesenchymal Transition
Negative Regulation Of Angiogenesis
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of MAPK Cascade
Negative Regulation Of MAPK Cascade
Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Vasculogenesis Involved In Coronary Vascular Morphogenesis
Negative Regulation Of ERK1 And ERK2 Cascade
Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Negative Regulation Of Intracellular Signal Transduction
Negative Regulation Of Lens Fiber Cell Differentiation
Endocytosis
Signal Transduction
Vesicle-mediated Transport
Intracellular Signal Transduction
Pathways
Regulation of RAS by GAPs
FGFRL1 modulation of FGFR1 signaling
RAS signaling downstream of NF1 loss-of-function variants
RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS
Bipolar disorder (
20351715
)
Birth weight (
31043758
)
Cognitive performance (processing speed) (
31598132
)
Crohn's disease (
23128233
)
Erosive tooth wear (severe vs non-severe) (
29898447
)
Erosive tooth wear (severe vs none or mild) (
29898447
)
HDL cholesterol levels x long total sleep time interaction (2df test) (
31719535
)
Hypersomnia (HLA-DQB1*06:02 negative) (
23646285
)
Bipolar disorder (
21926972
31043756
)
Interacting Genes
40 interacting genes:
ANKS1A
AQP1
BEX2
BLZF1
C2orf68
CCDC185
CDKN1A
CREB5
DNAJB11
DSCR9
DYRK1A
FAM118B
FAM90A1
GLYCTK
HEXIM2
HPCAL4
HSF2BP
IL16
KIT
MAB21L3
MEOX2
NAGK
NCALD
OSGEP
PIH1D2
PPP1CA
PPP1R7
PRPF18
RBM11
RCC1
RIN1
SPG21
SUV39H1
TSC22D1
TTC19
VSNL1
ZNF408
ZNF417
ZNF587
ZNF655
49 interacting genes:
ABL1
ABL2
AFDN
ANKS1A
ANKS1B
CALCOCO2
CAPNS2
CARD10
CRACR2B
EGFR
EIF3F
ERBB2
ERBB3
GOLGA2
GOLGA6L9
HMG20A
HRAS
HSF2BP
ITSN1
KLHL12
KRT34
KRTAP13-1
KRTAP15-1
LZTS2
MDFI
MTDH
PICK1
PLEKHG4
RAB5A
RAB5B
RALGDS
RRAS2
SEC23B
SH3RF1
SNX17
SORBS3
SPRED1
TBC1D1
TFIP11
TRAF2
TRIM23
TRIM27
TRIM7
TRIP10
TSC1
YWHAB
YWHAE
YWHAZ
ZBED1
Entrez ID
161742
9610
HPRD ID
11601
05813
Ensembl ID
ENSG00000166068
ENSG00000174791
Uniprot IDs
Q7Z699
A0A0S2Z4T5
A0A0S2Z4U0
Q13671
PDB IDs
3SYX
6V65
6V6F
Enriched GO Terms of Interacting Partners
?
Cytosol
Cytoplasm
Perinuclear Region Of Cytoplasm
Phosphoserine Residue Binding
Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of MAPK Cascade
ERBB Signaling Pathway
GDP Binding
Intracellular Signaling Cassette
MAPK Cascade
Identical Protein Binding
Regulation Of Intracellular Signal Transduction
Protein Sequestering Activity
ERBB3:ERBB2 Complex
Regulation Of Autophagy
Melanosome
Positive Regulation Of Intracellular Signal Transduction
Cellular Localization
Vesicle-mediated Transport
Schwann Cell Development
Protein Tyrosine Kinase Activity
Glial Cell Development
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
ERBB2 Signaling Pathway
Positive Regulation Of MAPK Cascade
Establishment Of Protein Localization
Positive Regulation Of Establishment Of T Cell Polarity
Regulation Of Actin Cytoskeleton Organization
Ephrin Receptor Binding
Establishment Of Localization In Cell
Regulation Of Cell Communication
Signal Transduction
Regulation Of Signaling
ErbB-3 Class Receptor Binding
Regulation Of Cellular Component Organization
Intracellular Transport
Regulation Of Actin Filament-based Process
Protein Binding
Regulation Of Establishment Of T Cell Polarity
Regulation Of Signal Transduction
Protein Modification Process
Regulation Of Fibroblast Proliferation
Regulation Of ERK1 And ERK2 Cascade
Protein Phosphatase Binding
Myelination
Axon Ensheathment
Regulation Of Protein Localization
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
ERBB2-EGFR Signaling Pathway
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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