DAD1 and GLP1R

Number of citations of the paper that reports this interaction (PubMedID 26272612)
67

Data Source:
BioGRID (protein complementation assay)

		DAD1	GLP1R
Description		defender against cell death 1	glucagon like peptide 1 receptor
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Oligosaccharyltransferase Complex Membrane Oligosaccharyltransferase Complex A Oligosaccharyltransferase Complex B	Plasma Membrane Membrane
	Molecular Function	Enzyme Activator Activity	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Glucagon Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Peptide Hormone Binding Signaling Receptor Activity Glucagon-like Peptide 1 Receptor Activity
	Biological Process	Blastocyst Development Protein Glycosylation Protein N-linked Glycosylation Apoptotic Process Protein N-linked Glycosylation Via Asparagine Regulation Of Protein Stability Negative Regulation Of Apoptotic Process	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Learning Or Memory Regulation Of Heart Contraction Post-translational Protein Targeting To Membrane, Translocation Negative Regulation Of Blood Pressure Positive Regulation Of Blood Pressure Hormone Secretion Regulation Of Biological Quality Cellular Response To Glucagon Stimulus Response To Psychosocial Stress
Pathways		Asparagine N-linked glycosylation Maturation of spike protein Regulation of CDH1 posttranslational processing and trafficking to plasma membrane PD-L1(CD274) glycosylation and translocation to plasma membrane	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion G alpha (s) signalling events Glucagon-type ligand receptors
Drugs			Glucagon Exenatide Liraglutide Albiglutide Dulaglutide Lixisenatide Semaglutide Taspoglutide Tirzepatide Efpeglenatide Glutazumab
Diseases
GWAS		Microalbuminuria ( 26631737) Relative hand skill in reading disability ( 24068947)	Blood sugar levels ( 29403010) Fasting blood glucose ( 25631608) Fasting blood glucose adjusted for BMI ( 25625282) Fasting glucose ( 34059833) Type 2 diabetes ( 32499647)
Interacting Genes		3 interacting genes: ETS2 GLP1R MCL1	112 interacting genes: ACSF3 AGXT AIG1 APH1A ARFRP1 ARLN ASGR2 ATP13A1 ATP5MC3 ATP6AP2 C18orf32 CALM1 CAND2 CAV1 CCDC167 CD63 CD81 CELA3B CEND1 CFI CLDN7 CLIP4 CLPS CNIH4 COMT CYSRT1 CYSTM1 DAD1 DHRS7 EBP ELOVL1 EMC7 EMP2 ERP29 FGL1 FTL GABBR2 GCG GJB1 GNAS GP2 GPR108 GPR37 GPRASP1 GRINA HAMP HPN IER3 IFITM3 KHK KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP17-1 KRTAP5-9 LAPTM4A LINC00269 MRPL22 MT-ATP6 MT-ND4L MTCH2 MYL6 NBPF19 NOTCH2NLA NRGN NUCKS1 OCIAD2 OST4 P4HTM PAM PAQR6 PGRMC1 PIGG POMT2 PPIB PRSS2 PSMD8 RAB5B RAB5C RNF5 RTN3 RTN4 RTRAF SAA1 SCGB2A1 SEC11C SELENOK SERPINA1 SLC15A4 SLC37A4 SLC61A1 SLC9D1 SPTSSA STMN1 STMN3 STOML2 SVOP SYNGR3 SYNGR4 SYS1 TM4SF4 TMBIM6 TMEM147 TMEM176B TOMM6 TSPAN13 UGT1A9 VAPB ZNF99
Entrez ID		1603	2740
HPRD ID		02589	00677
Ensembl ID		ENSG00000129562	ENSG00000112164
Uniprot IDs		P61803 Q53G02	A0A142FHB8 P43220
PDB IDs		6S7O 6S7T 8B6L 8PN9	3C59 3C5T 3IOL 4ZGM 5E94 5NX2 5OTT 5OTU 5OTV 5OTW 5OTX 5VEW 5VEX 6B3J 6GB1 6ORV 6VCB 6X18 6X19 6X1A 6XOX 7C2E 7DUQ 7DUR 7E14 7EVM 7FIM 7KI0 7KI1 7LCI 7LCJ 7LCK 7LLL 7LLY 7RG9 7RGP 7RTB 7S15 7S1M 7S3I 7VBH 7VBI 7X8R 7X8S 8JIP 8JIR 8JIS 8WG7 8YW3 9IVG 9IVM 9J1P
Enriched GO Terms of Interacting Partners?		Protein Transmembrane Transport Glucagon-like Peptide 1 Receptor Activity Ectodermal Cell Fate Commitment Glucagon Receptor Activity BH Domain Binding Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Response To Psychosocial Stress BH3 Domain Binding Post-translational Protein Targeting To Membrane, Translocation Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Bcl-2 Family Protein Complex Primitive Streak Formation Cellular Response To Glucagon Stimulus Cell Fate Commitment Involved In Formation Of Primary Germ Layer Activation Of Adenylate Cyclase Activity Nuclear Glucocorticoid Receptor Binding Positive Regulation Of Lyase Activity Positive Regulation Of Adenylate Cyclase Activity Response To Glucagon Mitochondrial Fusion Negative Regulation Of Anoikis Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Cyclase Activity Release Of Cytochrome C From Mitochondria Protein Transmembrane Transporter Activity Regulation Of Anoikis Intracellular Protein Transmembrane Transport Positive Regulation Of Blood Pressure Peptide Hormone Binding G Protein-coupled Peptide Receptor Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cell Fate Determination Channel Activity Negative Regulation Of Blood Pressure Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway	Endoplasmic Reticulum Membrane Membrane Endoplasmic Reticulum Intermediate Filament Host-mediated Perturbation Of Viral Genome Replication Host-mediated Activation Of Viral Genome Replication Keratin Filament Neutrophil Migration Host-mediated Activation Of Viral Process Endoplasmic Reticulum Membrane Organization Chemical Homeostasis Intracellular Chemical Homeostasis Synaptic Vesicle Membrane Intracellular Calcium Ion Homeostasis Intracellular Monoatomic Cation Homeostasis Granulocyte Migration
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