CYP4A11 and CYB5A

Number of citations of the paper that reports this interaction (PubMedID 10660572)
0

Data Source:
BioGRID (enzymatic study)

		CYP4A11	CYB5A
Description		cytochrome P450 family 4 subfamily A member 11	cytochrome b5 type A
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Apical Plasma Membrane Intracellular Membrane-bounded Organelle	Cytoplasm Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Monooxygenase Activity Iron Ion Binding Arachidonate Monooxygenase Activity Arachidonate Epoxygenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Alkane 1-monooxygenase Activity Heme Binding Metal Ion Binding Leukotriene-B4 20-monooxygenase Activity Arachidonate Omega-hydroxylase Activity Long-chain Fatty Acid Omega-hydroxylase Activity	Protein Binding Enzyme Binding Heme Binding Metal Ion Binding
	Biological Process	Long-chain Fatty Acid Metabolic Process Kidney Development Renal Water Homeostasis Pressure Natriuresis Lipid Metabolic Process Fatty Acid Metabolic Process Leukotriene Metabolic Process Arachidonate Metabolic Process Epoxygenase P450 Pathway Oxylipin Biosynthetic Process Positive Regulation Of Icosanoid Secretion Leukotriene B4 Catabolic Process Linoleic Acid Metabolic Process Icosanoid Biosynthetic Process Lauric Acid Metabolic Process Sodium Ion Homeostasis Omega-hydroxylase P450 Pathway
Pathways		PPARA activates gene expression Fatty acids Miscellaneous substrates Eicosanoids Synthesis of Leukotrienes (LT) and Eoxins (EX) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)	Vitamin C (ascorbate) metabolism
Drugs		NADH	Dimethyl Propionate Ester Heme Chromium Chromic citrate Chromic nitrate Chromium gluconate Chromium nicotinate Chromous sulfate
Diseases			Methemoglobinemia
GWAS		Serum metabolite concentrations in chronic kidney disease ( 33838163) Serum metabolite levels ( 23093944 33031748) Urinary metabolite levels in chronic kidney disease ( 31959995)	Blood protein levels ( 30072576)
Interacting Genes		2 interacting genes: CYB5A PIK3R1	14 interacting genes: CYB5R3 CYCS CYP17A1 CYP1A1 CYP1A2 CYP2A6 CYP2D6 CYP2E1 CYP2W1 CYP3A4 CYP4A11 POR SCD UGT1A4
Entrez ID		1579	1528
HPRD ID		03201	08941
Ensembl ID		ENSG00000187048	ENSG00000166347
Uniprot IDs		Q02928 V9GZ77	A0A384ME44 P00167
PDB IDs			2I96
Enriched GO Terms of Interacting Partners?		Kinase Regulator Activity Phosphatidylinositol 3-kinase Complex Phosphatidylinositol 3-kinase Activator Activity Phosphatidylinositol 3-kinase Complex, Class IA Insulin Binding Perinuclear Endoplasmic Reticulum Membrane 1-phosphatidylinositol-3-kinase Regulator Activity Phosphatidylinositol Kinase Activity Positive Regulation Of Focal Adhesion Disassembly Neurotrophin TRKA Receptor Binding Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Phosphatidylinositol 3-kinase Regulator Activity T Follicular Helper Cell Differentiation ErbB-3 Class Receptor Binding Kinase Activator Activity Insulin Receptor Substrate Binding Phosphatidylinositol 3-kinase Regulatory Subunit Binding Interleukin-18-mediated Signaling Pathway Enzyme-substrate Adaptor Activity Insulin-like Growth Factor Receptor Binding Phosphatidylinositol 3-kinase Binding Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors T-helper Cell Differentiation Regulation Of Toll-like Receptor 4 Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Stress Fiber Assembly Insulin Receptor Binding Growth Hormone Receptor Signaling Pathway Negative Regulation Of Osteoclast Differentiation Phosphotyrosine Residue Binding Positive Regulation Of Lamellipodium Assembly Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Cell-matrix Adhesion Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of D-glucose Import Regulation Of Lamellipodium Assembly Positive Regulation Of D-glucose Transmembrane Transport Osteoclast Differentiation Substrate Adhesion-dependent Cell Spreading T Cell Differentiation Involved In Immune Response Positive Regulation Of RNA Splicing Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Filopodium Assembly Positive Regulation Of Lamellipodium Organization Natural Killer Cell Mediated Immunity Negative Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Protein Import Into Nucleus Regulation Of Filopodium Assembly Cis-Golgi Network	Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Iron Ion Binding Heme Binding Monooxygenase Activity Xenobiotic Metabolic Process Oxidoreductase Activity Endoplasmic Reticulum Membrane Lipid Metabolic Process Steroid Metabolic Process Olefinic Compound Metabolic Process Intracellular Membrane-bounded Organelle Small Molecule Metabolic Process Monocarboxylic Acid Metabolic Process Endoplasmic Reticulum Fatty Acid Metabolic Process Epoxygenase P450 Pathway Unsaturated Fatty Acid Metabolic Process Arachidonate Metabolic Process Long-chain Fatty Acid Metabolic Process Secondary Metabolic Process Monoterpenoid Metabolic Process Small Molecule Biosynthetic Process Xenobiotic Catabolic Process Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Terpenoid Metabolic Process Long-chain Fatty Acid Biosynthetic Process Icosanoid Metabolic Process Demethylation Isoprenoid Metabolic Process Fatty Acid Biosynthetic Process Coumarin Metabolic Process Carboxylic Acid Biosynthetic Process Steroid Hydroxylase Activity Toxin Metabolic Process Alcohol Metabolic Process Lipid Biosynthetic Process Retinoid Metabolic Process Diterpenoid Metabolic Process Hormone Metabolic Process Oxygen Binding Lipid Hydroxylation Enzyme Binding Estrogen Metabolic Process Estrogen 16-alpha-hydroxylase Activity Estrogen 2-hydroxylase Activity Oxidative Demethylation Aflatoxin Metabolic Process Alkaloid Metabolic Process
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