CYP4A11

Description		cytochrome P450 family 4 subfamily A member 11
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Apical Plasma Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Monooxygenase Activity Iron Ion Binding Arachidonate Monooxygenase Activity Arachidonate Epoxygenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Alkane 1-monooxygenase Activity Heme Binding Metal Ion Binding Leukotriene-B4 20-monooxygenase Activity Arachidonate Omega-hydroxylase Activity Long-chain Fatty Acid Omega-hydroxylase Activity
	Biological Process	Long-chain Fatty Acid Metabolic Process Kidney Development Renal Water Homeostasis Pressure Natriuresis Lipid Metabolic Process Fatty Acid Metabolic Process Leukotriene Metabolic Process Arachidonate Metabolic Process Epoxygenase P450 Pathway Oxylipin Biosynthetic Process Positive Regulation Of Icosanoid Secretion Leukotriene B4 Catabolic Process Linoleic Acid Metabolic Process Icosanoid Biosynthetic Process Lauric Acid Metabolic Process Sodium Ion Homeostasis Omega-hydroxylase P450 Pathway
Pathways		PPARA activates gene expression Fatty acids Miscellaneous substrates Eicosanoids Synthesis of Leukotrienes (LT) and Eoxins (EX) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
Drugs		NADH
Diseases
GWAS		Serum metabolite concentrations in chronic kidney disease ( 33838163) Serum metabolite levels ( 23093944 33031748) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		2 interacting genes: CYB5A PIK3R1
Entrez ID		1579
HPRD ID		03201
Ensembl ID		ENSG00000187048
Uniprot IDs		Q02928 V9GZ77
PDB IDs
Enriched GO Terms of Interacting Partners?		Kinase Regulator Activity Phosphatidylinositol 3-kinase Complex Phosphatidylinositol 3-kinase Activator Activity Phosphatidylinositol 3-kinase Complex, Class IA Insulin Binding Perinuclear Endoplasmic Reticulum Membrane 1-phosphatidylinositol-3-kinase Regulator Activity Phosphatidylinositol Kinase Activity Positive Regulation Of Focal Adhesion Disassembly Neurotrophin TRKA Receptor Binding Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Phosphatidylinositol 3-kinase Regulator Activity T Follicular Helper Cell Differentiation ErbB-3 Class Receptor Binding Kinase Activator Activity Insulin Receptor Substrate Binding Phosphatidylinositol 3-kinase Regulatory Subunit Binding Interleukin-18-mediated Signaling Pathway Enzyme-substrate Adaptor Activity Insulin-like Growth Factor Receptor Binding Phosphatidylinositol 3-kinase Binding Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors T-helper Cell Differentiation Regulation Of Toll-like Receptor 4 Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Stress Fiber Assembly Insulin Receptor Binding Growth Hormone Receptor Signaling Pathway Negative Regulation Of Osteoclast Differentiation Phosphotyrosine Residue Binding Positive Regulation Of Lamellipodium Assembly Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Cell-matrix Adhesion Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of D-glucose Import Regulation Of Lamellipodium Assembly Positive Regulation Of D-glucose Transmembrane Transport Osteoclast Differentiation Substrate Adhesion-dependent Cell Spreading T Cell Differentiation Involved In Immune Response Positive Regulation Of RNA Splicing Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Filopodium Assembly Positive Regulation Of Lamellipodium Organization Natural Killer Cell Mediated Immunity Negative Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Protein Import Into Nucleus Regulation Of Filopodium Assembly Cis-Golgi Network
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