CYP4A11

Gene Name		cytochrome P450, family 4, subfamily A, polypeptide 11
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Apical Plasma Membrane Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome
	Molecular Function	Iron Ion Binding Arachidonic Acid Epoxygenase Activity Alkane 1-monooxygenase Activity Heme Binding Leukotriene-B4 20-monooxygenase Activity Arachidonic Acid Omega-hydroxylase Activity
	Biological Process	Long-chain Fatty Acid Metabolic Process Renal Water Homeostasis Pressure Natriuresis Fatty Acid Metabolic Process Leukotriene Metabolic Process Xenobiotic Metabolic Process Arachidonic Acid Metabolic Process Epoxygenase P450 Pathway Positive Regulation Of Icosanoid Secretion Leukotriene B4 Catabolic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Sodium Ion Homeostasis Oxidation-reduction Process Omega-hydroxylase P450 Pathway
Pathways		PPARA activates gene expression Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Metabolism of lipids and lipoproteins Metabolic disorders of biological oxidation enzymes Phase 1 - Functionalization of compounds Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Arachidonic acid metabolism Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Cytochrome P450 - arranged by substrate type Biological oxidations Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective FMO3 causes Trimethylaminuria (TMAU) Fatty acid, triacylglycerol, and ketone body metabolism Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Eicosanoids Synthesis of Leukotrienes (LT) and Eoxins (EX) Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Miscellaneous substrates Defective CYP1B1 causes Glaucoma Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Fatty acids Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3) Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs		NADH
Diseases
GWAS
Protein-protein Interactions		2 interactors: CYB5A PIK3R1
Entrez ID		1579
HPRD ID		03201
Ensembl ID		ENSG00000187048
Uniprot IDs		Q02928
PDB IDs
Enriched GO Terms of Interacting Partners?		NFAT Protein Import Into Nucleus Transcription Factor Import Into Nucleus Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response
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