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CYP4A11 and PIK3R1
Number of citations of the paper that reports this interaction (PMID
18624398
)
4
Data Source:
BioGRID
(two hybrid)
CYP4A11
PIK3R1
Gene Name
cytochrome P450, family 4, subfamily A, polypeptide 11
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytoplasm
Endoplasmic Reticulum Membrane
Apical Plasma Membrane
Intracellular Membrane-bounded Organelle
Extracellular Vesicular Exosome
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Cell-cell Junction
Phosphatidylinositol 3-kinase Complex
Phosphatidylinositol 3-kinase Complex, Class IA
Membrane
Molecular Function
Iron Ion Binding
Arachidonic Acid Epoxygenase Activity
Alkane 1-monooxygenase Activity
Heme Binding
Leukotriene-B4 20-monooxygenase Activity
Arachidonic Acid Omega-hydroxylase Activity
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Insulin Receptor Binding
Insulin-like Growth Factor Receptor Binding
Neurotrophin TRKA Receptor Binding
Protein Binding
Transcription Factor Binding
Protein Phosphatase Binding
Phosphatidylinositol 3-kinase Regulator Activity
ErbB-3 Class Receptor Binding
Phosphatidylinositol 3-kinase Binding
Insulin Binding
Insulin Receptor Substrate Binding
Biological Process
Long-chain Fatty Acid Metabolic Process
Renal Water Homeostasis
Pressure Natriuresis
Fatty Acid Metabolic Process
Leukotriene Metabolic Process
Xenobiotic Metabolic Process
Arachidonic Acid Metabolic Process
Epoxygenase P450 Pathway
Positive Regulation Of Icosanoid Secretion
Leukotriene B4 Catabolic Process
Cellular Lipid Metabolic Process
Small Molecule Metabolic Process
Sodium Ion Homeostasis
Oxidation-reduction Process
Omega-hydroxylase P450 Pathway
Cellular Glucose Homeostasis
Negative Regulation Of Cell-matrix Adhesion
Protein Phosphorylation
Phospholipid Metabolic Process
Phosphatidylinositol Biosynthetic Process
Epidermal Growth Factor Receptor Signaling Pathway
Blood Coagulation
Insulin Receptor Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Phosphatidylinositol 3-kinase Signaling
Viral Process
Platelet Activation
B Cell Differentiation
Positive Regulation Of Cell Migration
T Cell Costimulation
Positive Regulation Of Tumor Necrosis Factor Production
Cellular Response To Insulin Stimulus
Positive Regulation Of RNA Splicing
Cellular Response To UV
Response To Endoplasmic Reticulum Stress
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Positive Regulation Of Transcription Factor Import Into Nucleus
Negative Regulation Of Apoptotic Process
Regulation Of Phosphatidylinositol 3-kinase Activity
Small Molecule Metabolic Process
Innate Immune Response
Negative Regulation Of Osteoclast Differentiation
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Glucose Import
Phosphatidylinositol Phosphorylation
Insulin-like Growth Factor Receptor Signaling Pathway
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Phosphatidylinositol-mediated Signaling
Protein Stabilization
T Cell Receptor Signaling Pathway
Leukocyte Migration
NFAT Protein Import Into Nucleus
Growth Hormone Receptor Signaling Pathway
Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane
Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response
Pathways
PPARA activates gene expression
Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B)
Metabolism of lipids and lipoproteins
Metabolic disorders of biological oxidation enzymes
Phase 1 - Functionalization of compounds
Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A)
Arachidonic acid metabolism
Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4)
Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56)
Cytochrome P450 - arranged by substrate type
Biological oxidations
Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD)
Defective FMO3 causes Trimethylaminuria (TMAU)
Fatty acid, triacylglycerol, and ketone body metabolism
Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)
Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX)
Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4)
Eicosanoids
Synthesis of Leukotrienes (LT) and Eoxins (EX)
Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA)
Miscellaneous substrates
Defective CYP1B1 causes Glaucoma
Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5)
Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3)
Defective CYP19A1 causes Aromatase excess syndrome (AEXS)
Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5)
Fatty acids
Defective CYP24A1 causes Hypercalcemia, infantile (HCAI)
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
Defective MAOA causes Brunner syndrome (BRUNS)
Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency)
Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Signaling by the B Cell Receptor (BCR)
Signaling by GPCR
Metabolism of lipids and lipoproteins
Signaling by FGFR in disease
Signaling by EGFRvIII in Cancer
Signaling by SCF-KIT
Downstream signaling events of B Cell Receptor (BCR)
DAP12 signaling
PI3K/AKT activation
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
Interleukin receptor SHC signaling
PI-3K cascade
Gastrin-CREB signalling pathway via PKC and MAPK
Signaling by FGFR1 mutants
Interleukin-7 signaling
Role of phospholipids in phagocytosis
Phospholipid metabolism
Fcgamma receptor (FCGR) dependent phagocytosis
PI3K Cascade
Signaling by PDGF
DAP12 interactions
GAB1 signalosome
G-protein beta:gamma signalling
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
Signaling by ERBB4
Constitutive PI3K/AKT Signaling in Cancer
Role of LAT2/NTAL/LAB on calcium mobilization
PI3K events in ERBB4 signaling
G alpha (q) signalling events
Signaling by ERBB2
Signaling by EGFR
GPCR downstream signaling
Signaling by Interleukins
TCR signaling
Signaling by VEGF
GP1b-IX-V activation signalling
Downstream signal transduction
Signaling by FGFR mutants
Fc epsilon receptor (FCERI) signaling
Signaling by EGFR in Cancer
Nephrin interactions
Interleukin-2 signaling
PI3K/AKT Signaling in Cancer
Platelet activation, signaling and aggregation
Interleukin-3, 5 and GM-CSF signaling
Adaptive Immune System
G alpha (q) signalling events
Downstream TCR signaling
Costimulation by the CD28 family
IRS-mediated signalling
PIP3 activates AKT signaling
IGF1R signaling cascade
VEGFA-VEGFR2 Pathway
Synthesis of PIPs at the plasma membrane
IRS-related events triggered by IGF1R
G beta:gamma signalling through PI3Kgamma
PI3K events in ERBB2 signaling
Regulation of signaling by CBL
Downstream signaling of activated FGFR
G alpha (12/13) signalling events
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
PI Metabolism
Innate Immune System
Signaling by Insulin receptor
Signalling by NGF
Insulin receptor signalling cascade
Cytokine Signaling in Immune system
Signaling by Ligand-Responsive EGFR Variants in Cancer
IRS-related events
NGF signalling via TRKA from the plasma membrane
Tie2 Signaling
Signaling by Overexpressed Wild-Type EGFR in Cancer
Cell surface interactions at the vascular wall
Signaling by FGFR
IRS-mediated signalling
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
GPVI-mediated activation cascade
Interleukin receptor SHC signaling
Signaling by FGFR1 fusion mutants
Constitutive Signaling by EGFRvIII
PI3K Cascade
Drugs
NADH
Isoproterenol
(1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4,3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE
Diseases
GWAS
Alzheimer's disease biomarkers (
23419831
)
Menarche (age at onset) (
23599027
)
Protein-Protein Interactions
2 interactors:
CYB5A
PIK3R1
149 interactors:
ABL1
ADAM12
ADAMTS2
AGAP2
AKT1
ALK
ANK3
ARAF
ARHGAP1
ARHGAP17
ARHGAP32
AXL
BCAR1
BRCA1
CBL
CBLB
CCL14
CD19
CD22
CD28
CD2AP
CD3E
CD4
CD40
CD5
CD7
CDC42
CDH2
CHRNA7
CRK
CRKL
CSF1R
CSF2RA
CTLA4
CTNNB1
CXCL2
CYP4A11
DLX2
DNM1
DOK1
EGFR
EPHA2
EPOR
ERAS
ERBB2
ERBB3
ESR1
EZR
FASLG
FCGR2A
FES
FGFR1
FYN
GAB1
GAB2
GAB3
GHR
GRB2
GSK3B
GSPT1
GTF2H1
HCK
HCST
HDAC1
HGS
HOXA1
HRAS
HTT
IFNAR1
IGF1R
IL13
IL1R1
IL1RAP
IL2RB
IL7R
INPP4A
INSR
IRS1
IRS2
IRS4
ITSN1
JAK1
JAK2
JAK3
KHDRBS1
KIT
LAT
LCK
LCP2
MAPK8
MET
MME
MST1R
NFKBIA
NTRK1
NTRK2
NUP85
PDGFRA
PDGFRB
PECAM1
PFN1
PIK3AP1
PIK3CA
PIK3CB
PIK3CD
PPM1A
PSEN1
PSMB5
PTK2
PTK2B
PTPN11
PTPN6
RAC1
RASA1
RB1
RET
RRAS2
SH3KBP1
SHB
SHC1
SLC9A2
SOCS1
SOCS6
SOCS7
SRC
SSTR2
SYK
SYN1
TEC
TEK
TGFBR1
TGFBR2
TIE1
TLR2
TOM1L1
TRAT1
TSHR
TTR
TUB
TUBA1B
TUBG1
TYK2
TYRO3
VAV1
VAV3
WAS
WASF3
WBP11
YWHAG
Entrez ID
1579
5295
HPRD ID
03201
01381
Ensembl ID
ENSG00000187048
ENSG00000145675
Uniprot IDs
Q02928
P27986
PDB IDs
1A0N
1AZG
1H9O
1PBW
1PHT
1PIC
1PKS
1PKT
2IUG
2IUH
2IUI
2RD0
2V1Y
3HHM
3HIZ
3I5R
3I5S
4A55
Enriched GO Terms of Interacting Partners
?
NFAT Protein Import Into Nucleus
Transcription Factor Import Into Nucleus
Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Signal Transduction
Signaling
Cellular Response To Stimulus
Cell Communication
Cell Surface Receptor Signaling Pathway
Cellular Response To Organic Substance
Positive Regulation Of Signal Transduction
Response To Organic Substance
Regulation Of Signal Transduction
Immune System Process
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Regulation Of Immune System Process
Regulation Of Signaling
Intracellular Signal Transduction
Response To Stimulus
Immune Response-regulating Signaling Pathway
Regulation Of Immune Response
Immune Response
Fc Receptor Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Innate Immune Response
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Intracellular Signal Transduction
Peptidyl-tyrosine Phosphorylation
Neurotrophin TRK Receptor Signaling Pathway
Neurotrophin Signaling Pathway
Regulation Of Phosphorylation
Regulation Of Kinase Activity
Locomotion
Defense Response
Positive Regulation Of Phosphorylation
Response To Growth Factor
Regulation Of Phosphorus Metabolic Process
Movement Of Cell Or Subcellular Component
Cellular Response To Growth Factor Stimulus
Fc-epsilon Receptor Signaling Pathway
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Immune System Process
Cell Migration
Positive Regulation Of Metabolic Process
Cell Activation
Phosphatidylinositol-mediated Signaling
Positive Regulation Of Kinase Activity
Regulation Of Protein Phosphorylation
Regulation Of Cell Proliferation
Cell Motility
Tagcloud
?
16q
1q
affymetrix
classic
clustering
clusters
cytoskeleton
distinguished
epithelium
fresh
frozen
golm1
gpr137b
hierarchical
ilc
lcis
lobular
mastectomy
microarrays
microdissected
obligate
personalize
precursor
prophylactic
supervised
transcriptomic
triplets
u133a
unsupervised
Tagcloud (Difference)
?
16q
1q
affymetrix
classic
clustering
clusters
cytoskeleton
distinguished
epithelium
fresh
frozen
golm1
gpr137b
hierarchical
ilc
lcis
lobular
mastectomy
microarrays
microdissected
obligate
personalize
precursor
prophylactic
supervised
transcriptomic
triplets
u133a
unsupervised
Tagcloud (Intersection)
?