ADRBK2 and CCR4

Number of citations of the paper that reports this interaction (PMID 10754297)
27

Data Source:
HPRD (in vivo)

		ADRBK2	CCR4
Gene Name		adrenergic, beta, receptor kinase 2	chemokine (C-C motif) receptor 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component		Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Neuronal Cell Body
	Molecular Function	Protein Kinase Activity G-protein Coupled Receptor Kinase Activity ATP Binding Beta-adrenergic Receptor Kinase Activity	Chemokine Receptor Activity C-C Chemokine Receptor Activity
	Biological Process	Protein Phosphorylation Signal Transduction Receptor Internalization Termination Of G-protein Coupled Receptor Signaling Pathway	Neuron Migration Tolerance Induction Chemotaxis Inflammatory Response Immune Response G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Radiation Response To Bacterium Response To Antibiotic Positive Regulation Of Positive Chemotaxis Chemokine-mediated Signaling Pathway
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs		Adenosine triphosphate
Diseases
GWAS			Celiac disease ( 20190752)
Protein-Protein Interactions		7 interactors: AGTR1 BDKRB2 CCR4 CCR5 CXCR4 GIT1 OPRM1	6 interactors: ADRBK1 ADRBK2 CCL17 CCL22 CCL3 CCL5
Entrez ID		157	1233
HPRD ID		00183	05324
Ensembl ID		ENSG00000100077
Uniprot IDs		P35626 Q8N433	A0N0Q1 P51679
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cytosolic Calcium Ion Concentration Cytosolic Calcium Ion Homeostasis Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Cellular Chemical Homeostasis Ion Homeostasis Cellular Homeostasis Chemical Homeostasis Inflammatory Response G-protein Coupled Receptor Signaling Pathway Chemotaxis Homeostatic Process Chemokine-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Response To External Stimulus Calcium-mediated Signaling Dendritic Cell Chemotaxis Second-messenger-mediated Signaling Locomotion Defense Response Cell Chemotaxis Movement Of Cell Or Subcellular Component Dendritic Cell Migration Response To Other Organism Signal Transduction Response To Biotic Stimulus Signaling Cell Migration Cell Communication Positive Regulation Of Cell Differentiation Cell Motility Entry Into Host Cell Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Regulation Of Vasoconstriction Cellular Response To Stimulus Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Blood Vessel Size Regulation Of Tube Size Cytokine-mediated Signaling Pathway Response To Bacterium Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Wnt Protein Secretion Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Phospholipase C-activating Angiotensin-activated Signaling Pathway Interaction With Host	Cell Chemotaxis Positive Regulation Of Natural Killer Cell Chemotaxis Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Inflammatory Response Eosinophil Chemotaxis Eosinophil Migration Negative Regulation By Host Of Viral Transcription Immune Response Defense Response Monocyte Chemotaxis Chemotaxis Macrophage Chemotaxis Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of Viral Transcription Positive Chemotaxis Cell Migration Regulation Of Lymphocyte Migration Interaction With Symbiont Cell Motility Cell-cell Signaling Immune System Process Lipopolysaccharide-mediated Signaling Pathway Protein Kinase B Signaling Receptor Internalization Cellular Response To Interleukin-1 Granulocyte Chemotaxis Termination Of G-protein Coupled Receptor Signaling Pathway Locomotion Termination Of Signal Transduction Positive Regulation Of Leukocyte Chemotaxis Signal Transduction Regulation Of Viral Transcription Protein Phosphorylation Negative Regulation Of Viral Process Positive Regulation Of Phospholipase Activity Receptor Metabolic Process Signaling Vesicle-mediated Transport Response To Interleukin-1 Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Positive Regulation Of Leukocyte Migration Cell Communication Movement Of Cell Or Subcellular Component Positive Regulation Of Calcium Ion Transport Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Cellular Response To Tumor Necrosis Factor Leukocyte Chemotaxis Positive Regulation Of Chemotaxis Regulation Of Leukocyte Migration
Tagcloud ?		17p13 22q11 adrenergic ark ark1 ark2 arrb2 arrestin assignment band chromosome coding cofactor coupled desensitization grk4 grk5 grk6 includes it11 mapped mapping multigene occupied phosphorylates q37 refine rhodopsin sag	allergic ccr1 ccr3 ccr5 chemokine chemokines coreceptors cxc cxcr1 cxcr3 dictate helper homing ige immunodeficiency lesser leukocyte migrate polypeptide precise preferentially prominent superfamily th1 th1s th2 th2s upregulate
Tagcloud (Difference) ?		17p13 22q11 adrenergic ark ark1 ark2 arrb2 arrestin assignment band chromosome coding cofactor coupled desensitization grk4 grk5 grk6 includes it11 mapped mapping multigene occupied phosphorylates q37 refine rhodopsin sag	allergic ccr1 ccr3 ccr5 chemokine chemokines coreceptors cxc cxcr1 cxcr3 dictate helper homing ige immunodeficiency lesser leukocyte migrate polypeptide precise preferentially prominent superfamily th1 th1s th2 th2s upregulate
Tagcloud (Intersection) ?