GRK3

Name	G protein-coupled receptor kinase 3
Structure	No pdb structure
Novel Interactors	1 novel interactors: CHEK2
Interactors	11 interactors: ADRB2 AGTR1 BDKRB2 CCR4 CCR5 CXCR4 GIT1 HSPB1 OPRM1 SMURF1 SNCA
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cell Projection Synapse Presynapse Postsynapse
	Molecular Function	Nucleotide Binding G Protein-coupled Receptor Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity G Protein-coupled Receptor Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Beta-adrenergic Receptor Kinase Activity
	Biological Process	Desensitization Of G Protein-coupled Receptor Signaling Pathway Signal Transduction G Protein-coupled Receptor Signaling Pathway Receptor Internalization
Pathways	G alpha (s) signalling events Cargo recognition for clathrin-mediated endocytosis
Drugs	ATP
GWAS	No GWAS studies recorded
Entrez ID	157
HPRD ID	00183
Ensembl ID	ENSG00000100077
Uniprot IDs	P35626 Q8N433
PDB IDs	Not available
GO Terms Enriched among Interactors ?	G Protein-coupled Receptor Activity Positive Regulation Of Cytosolic Calcium Ion Concentration G Protein-coupled Receptor Signaling Pathway Regulation Of Biological Quality Chemokine Receptor Activity C-C Chemokine Binding C-C Chemokine Receptor Activity Negative Regulation Of Cell Communication Negative Regulation Of Signaling Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Calcium-mediated Signaling Endosome Cell Surface Receptor Signaling Pathway Cell Chemotaxis Negative Regulation Of Signal Transduction Regulation Of Multicellular Organismal Process Inflammatory Response Regulation Of Signal Transduction Chemokine-mediated Signaling Pathway Positive Regulation Of Catabolic Process Response To Stress Plasma Membrane Chemotaxis Dendritic Cell Chemotaxis Intracellular Signal Transduction Symbiont Entry Into Host Cell Locomotion Regulation Of Autophagy Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Dendritic Cell Migration Positive Regulation Of Developmental Process Blood Vessel Diameter Maintenance Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Tube Size Biological Process Involved In Interaction With Host Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Positive Regulation Of Organelle Organization Regulation Of Systemic Arterial Blood Pressure Response To Cytokine Positive Regulation Of Cellular Component Organization Positive Regulation Of Metabolic Process Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Vasodilation Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Mini Excitatory Postsynaptic Potential Identical Protein Binding Angiotensin Type I Receptor Activity