GRK3 and BDKRB2

Number of citations: 0 (PubMedID 11517230)
Data Source: HPRD (in vivo, in vitro)

		GRK3	BDKRB2
Name		G protein-coupled receptor kinase 3	bradykinin receptor B2
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cell Projection Synapse Presynapse Postsynapse	Endosome Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding G Protein-coupled Receptor Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity G Protein-coupled Receptor Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Beta-adrenergic Receptor Kinase Activity	Protease Binding Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity G Protein-coupled Receptor Activity Bradykinin Receptor Activity Protein Binding Type 1 Angiotensin Receptor Binding Protein Heterodimerization Activity
	Biological Process	Desensitization Of G Protein-coupled Receptor Signaling Pathway Signal Transduction G Protein-coupled Receptor Signaling Pathway Receptor Internalization	System Process Smooth Muscle Contraction Inflammatory Response Signal Transduction Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Circulation Response To Salt Stress Regulation Of Vasoconstriction Vasoconstriction Vasodilation Regulation Of Vascular Permeability Arachidonate Secretion Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator
Pathways		G alpha (s) signalling events Cargo recognition for clathrin-mediated endocytosis	Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events
Drugs		ATP	Anatibant Icatibant Labradimil
GWAS		No GWAS studies recorded	Cerebrospinal fluid AB1-42 levels ( 28247064 ) Corneal astigmatism ( 30306274 ) Gout ( 22179738 ) Gut microbiota alpha diversity (PD_whole_tree index) ( 33208821 ) Gut microbiota relative abundance (unclassified genus belonging to the order Clostridiales) ( 33208821 ) Mumps ( 28928442 ) Subcutaneous adipose tissue ( 26480920 )
Novel Interactors		1 novel interactors: CHEK2	None recorded
Interacting Genes		11 interacting genes: ADRB2 AGTR1 BDKRB2 CCR4 CCR5 CXCR4 GIT1 HSPB1 OPRM1 SMURF1 SNCA	33 interacting genes: AATK ACE AGTR1 AP2M1 CD81 CD82 CLCA4 EFS GNA11 GRK2 GRK3 GRK4 GRK5 GRK6 HERC2 INF2 MPI NIF3L1 NOS1 NOS3 PEX16 PRKCD PTPN11 SLC2A8 SLC35A4 SPG7 SPNS1 SYNE1 SYNGR2 TMEM11 TMEM70 TPI1 USP4
Entrez ID		157	624
HPRD ID		00183	00213
Ensembl ID		ENSG00000100077	ENSG00000168398
Uniprot IDs		P35626 Q8N433	P30411
PDB IDs		Not available	7F2O 7F6H 7F6I
GO Terms Enriched among Interactors		G Protein-coupled Receptor Activity Positive Regulation Of Cytosolic Calcium Ion Concentration G Protein-coupled Receptor Signaling Pathway Regulation Of Biological Quality Chemokine Receptor Activity C-C Chemokine Binding C-C Chemokine Receptor Activity Negative Regulation Of Cell Communication Negative Regulation Of Signaling Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Calcium-mediated Signaling Endosome Cell Surface Receptor Signaling Pathway Cell Chemotaxis Negative Regulation Of Signal Transduction Regulation Of Multicellular Organismal Process Inflammatory Response Regulation Of Signal Transduction Chemokine-mediated Signaling Pathway Positive Regulation Of Catabolic Process Response To Stress Plasma Membrane Chemotaxis Dendritic Cell Chemotaxis Intracellular Signal Transduction Symbiont Entry Into Host Cell Locomotion Regulation Of Autophagy Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Dendritic Cell Migration Positive Regulation Of Developmental Process Blood Vessel Diameter Maintenance Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Tube Size Biological Process Involved In Interaction With Host Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Positive Regulation Of Organelle Organization Regulation Of Systemic Arterial Blood Pressure Response To Cytokine Positive Regulation Of Cellular Component Organization Positive Regulation Of Metabolic Process Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Vasodilation Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Mini Excitatory Postsynaptic Potential Identical Protein Binding Angiotensin Type I Receptor Activity	G Protein-coupled Receptor Kinase Activity Beta-adrenergic Receptor Kinase Activity Receptor Internalization Regulation Of G Protein-coupled Receptor Signaling Pathway Bradykinin Receptor Binding Vasodilation Protein Serine/threonine Kinase Activity Blood Vessel Diameter Maintenance Regulation Of Tube Size Nitric-oxide Synthase Activity Tetrahydrobiopterin Binding Regulation Of The Force Of Heart Contraction Regulation Of Blood Pressure Receptor-mediated Endocytosis Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Cadmium Ion Binding Protein Kinase Activity Regulation Of The Force Of Heart Contraction By Chemical Signal Desensitization Of G Protein-coupled Receptor Signaling Pathway Negative Adaptation Of Signaling Pathway L-arginine Catabolic Process Regulation Of Systemic Arterial Blood Pressure Tachykinin Receptor Signaling Pathway Arginine Binding Regulation Of Blood Circulation Kinase Activity Plasma Membrane Membrane Vascular Process In Circulatory System Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin FMN Binding Circulatory System Process G Protein-coupled Receptor Binding Regulation Of Heart Contraction G Protein-coupled Receptor Signaling Pathway Regulation Of Transport Regulation Of Biological Quality Regulation Of System Process Arginine Metabolic Process Negative Regulation Of Platelet Activation Angiotensin-activated Signaling Pathway Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Nitric Oxide Mediated Signal Transduction G Protein-coupled Acetylcholine Receptor Signaling Pathway Metalloendopeptidase Activity Nitric Oxide Biosynthetic Process Positive Regulation Of Transport Regulation Of Cell Communication Regulation Of Signaling