ADRBK2 and BDKRB2

Number of citations of the paper that reports this interaction (PMID 11517230)
13

Data Source:
HPRD (in vivo, in vitro)

		ADRBK2	BDKRB2
Gene Name		adrenergic, beta, receptor kinase 2	bradykinin receptor B2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component		Endosome Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Protein Kinase Activity G-protein Coupled Receptor Kinase Activity ATP Binding Beta-adrenergic Receptor Kinase Activity	Protease Binding Phosphatidylinositol Phospholipase C Activity Bradykinin Receptor Activity Protein Binding Type 1 Angiotensin Receptor Binding Protein Heterodimerization Activity
	Biological Process	Protein Phosphorylation Signal Transduction Receptor Internalization Termination Of G-protein Coupled Receptor Signaling Pathway	Smooth Muscle Contraction Inflammatory Response Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Circulation Metabolic Process Response To Salt Stress Regulation Of Vasoconstriction Negative Regulation Of Peptidyl-serine Phosphorylation Vasoconstriction Vasodilation Regulation Of Vascular Permeability Arachidonic Acid Secretion Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs		Adenosine triphosphate
Diseases
GWAS
Protein-Protein Interactions		7 interactors: AGTR1 BDKRB2 CCR4 CCR5 CXCR4 GIT1 OPRM1	12 interactors: ACE ADRBK1 ADRBK2 AGTR1 GNA11 GRK4 GRK5 GRK6 NOS1 NOS3 PRKCD PTPN11
Entrez ID		157	624
HPRD ID		00183	00213
Ensembl ID		ENSG00000100077	ENSG00000168398
Uniprot IDs		P35626 Q8N433	P30411
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cytosolic Calcium Ion Concentration Cytosolic Calcium Ion Homeostasis Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Cellular Chemical Homeostasis Ion Homeostasis Cellular Homeostasis Chemical Homeostasis Inflammatory Response G-protein Coupled Receptor Signaling Pathway Chemotaxis Homeostatic Process Chemokine-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Response To External Stimulus Calcium-mediated Signaling Dendritic Cell Chemotaxis Second-messenger-mediated Signaling Locomotion Defense Response Cell Chemotaxis Movement Of Cell Or Subcellular Component Dendritic Cell Migration Response To Other Organism Signal Transduction Response To Biotic Stimulus Signaling Cell Migration Cell Communication Positive Regulation Of Cell Differentiation Cell Motility Entry Into Host Cell Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Regulation Of Vasoconstriction Cellular Response To Stimulus Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Blood Vessel Size Regulation Of Tube Size Cytokine-mediated Signaling Pathway Response To Bacterium Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Wnt Protein Secretion Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Phospholipase C-activating Angiotensin-activated Signaling Pathway Interaction With Host	Termination Of Signal Transduction Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of Signaling Regulation Of Vasodilation Negative Regulation Of Signal Transduction Blood Circulation Regulation Of The Force Of Heart Contraction Signal Transduction Regulation Of Signal Transduction Receptor Internalization Blood Coagulation Signaling Hemostasis Regulation Of Blood Pressure Regulation Of Signaling Cell Communication Positive Regulation Of Catalytic Activity Regulation Of The Force Of Heart Contraction By Chemical Signal Regulation Of Body Fluid Levels Positive Regulation Of Phospholipase Activity Wound Healing Arginine Catabolic Process Cellular Response To Stimulus Tachykinin Receptor Signaling Pathway Receptor Metabolic Process Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Positive Regulation Of Guanylate Cyclase Activity Response To Wounding Regulation Of Systemic Arterial Blood Pressure Nitric Oxide Biosynthetic Process Regulation Of Blood Volume By Renin-angiotensin Protein Phosphorylation Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Cell Surface Receptor Signaling Pathway Negative Regulation Of Platelet Activation Cellular Protein Metabolic Process Nitric Oxide Mediated Signal Transduction Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Cellular Protein Modification Process Positive Regulation Of CGMP Biosynthetic Process Positive Regulation Of CGMP Metabolic Process Arginine Metabolic Process Second-messenger-mediated Signaling Positive Regulation Of MRNA Catabolic Process Regulation Of Catalytic Activity Negative Regulation Of Potassium Ion Transport Regulation Of CGMP Biosynthetic Process
Tagcloud ?		17p13 22q11 adrenergic ark ark1 ark2 arrb2 arrestin assignment band chromosome coding cofactor coupled desensitization grk4 grk5 grk6 includes it11 mapped mapping multigene occupied phosphorylates q37 refine rhodopsin sag	arg10 arg9 arrangement b1 bk box consensus des entirely etc exon exons extension exudation flanking hyperalgesia hyperemia intron introns kallidin kinin kininase lys noncoding primer sequenced situated tata
Tagcloud (Difference) ?		17p13 22q11 adrenergic ark ark1 ark2 arrb2 arrestin assignment band chromosome coding cofactor coupled desensitization grk4 grk5 grk6 includes it11 mapped mapping multigene occupied phosphorylates q37 refine rhodopsin sag	arg10 arg9 arrangement b1 bk box consensus des entirely etc exon exons extension exudation flanking hyperalgesia hyperemia intron introns kallidin kinin kininase lys noncoding primer sequenced situated tata
Tagcloud (Intersection) ?