BLMH and AP1M2

Number of citations: 58 (PubMedID 21163940)
Data Source: BioGRID (two hybrid)

		BLMH	AP1M2
Name		bleomycin hydrolase	adaptor related protein complex 1 subunit mu 2
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Extracellular Exosome	Golgi Membrane Lysosomal Membrane Golgi Apparatus Cytosol Membrane AP-1 Adaptor Complex Clathrin Adaptor Complex Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane
	Molecular Function	Aminopeptidase Activity Carboxypeptidase Activity Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Identical Protein Binding Cysteine-type Aminopeptidase Activity	Protein Binding Clathrin Adaptor Activity
	Biological Process	Protein Polyubiquitination Proteolysis Response To Xenobiotic Stimulus Response To Toxic Substance Homocysteine Catabolic Process	Protein Targeting Intracellular Protein Transport Vesicle Targeting Protein Transport Vesicle-mediated Transport Establishment Of Protein Localization Establishment Of Localization In Cell Basolateral Protein Secretion
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Nef mediated downregulation of MHC class I complex cell surface expression MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis
GWAS		No GWAS studies recorded	Bipolar disorder ( 31043756 ) Lymphocyte percentage of white cells ( 27863252 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Platelet count ( 27863252 ) Plateletcrit ( 27863252 32888494 ) Red cell distribution width ( 27863252 28957414 32888494 )
Novel Interactors		None recorded	1 novel interactors: CDK12
Interacting Genes		20 interacting genes: AP1M2 APP CDC42 CEBPA CYP2C8 ECSIT KBTBD7 MAST1 NTAQ1 NXF1 PDPK1 PGLS RNF32 RPL11 RPL29 TNPO2 TNPO3 TRIM47 TRIO UBE2I	20 interacting genes: A2M AP1B1 AP1G1 AP1M1 AP1S1 AP2B1 APP BLMH ECSIT EHD2 GAK LDLR LOXL4 MAST1 NDRG1 PSEN1 PVR RAB3A RAB3D TGOLN2
Entrez ID		642	10053
HPRD ID		03870	06296
Ensembl ID		ENSG00000108578	ENSG00000129354
Uniprot IDs		Q13867	Q53GI5 Q9Y6Q5
PDB IDs		1CB5 2CB5 7V5L 7V5S 7V5T 7XF9	Not available
GO Terms Enriched among Interactors		Cytosol Cytoplasm Postsynapse Intracellular Transport Nuclear Transport Nucleocytoplasmic Transport Nuclear Import Signal Receptor Activity	AP-1 Adaptor Complex Early Endosome Melanosome Assembly Clathrin Adaptor Activity Basolateral Protein Secretion Platelet Dense Granule Organization Clathrin-coated Pit Vesicle-mediated Transport Membrane Coat Melanosome Organization Pigment Granule Organization Trans-Golgi Network Membrane Cytoplasmic Vesicle Clathrin Adaptor Complex Import Into Cell Intracellular Transport Establishment Of Localization In Cell Synaptic Vesicle Endocytosis Secretory Granule Organization Regulation Of Amyloid Fibril Formation GTP-dependent Protein Binding Regulation Of Vesicle-mediated Transport Cellular Localization Lysosomal Membrane Secretion By Cell Presynapse Astrocyte Activation Involved In Immune Response Clathrin Binding Clathrin-coated Vesicle Membrane Golgi Apparatus Protein Localization To Extracellular Region Protein Secretion Establishment Of Protein Localization To Extracellular Region Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Intracellular Protein Localization Endosome Protein Transport Secretion Positive Regulation Of Regulated Secretory Pathway Vesicle Organization Positive Regulation Of Transport Cytoplasmic Vesicle Membrane Receptor-mediated Endocytosis Endosome To Melanosome Transport Establishment Of Protein Localization Golgi To Lysosome Transport Clathrin-coated Endocytic Vesicle Membrane Clathrin-coated Vesicle