CYP2A6 and POR

Number of citations of the paper that reports this interaction (PMID 15680923)
10

Data Source:
BioGRID (pull down, pull down)

		CYP2A6	POR
Gene Name		cytochrome P450, family 2, subfamily A, polypeptide 6	P450 (cytochrome) oxidoreductase
Image
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Cytoplasmic Microtubule Intracellular Membrane-bounded Organelle	Mitochondrion Endoplasmic Reticulum Membrane Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Iron Ion Binding Coumarin 7-hydroxylase Activity Arachidonic Acid Epoxygenase Activity Steroid Hydroxylase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Oxygen Binding Enzyme Binding Heme Binding	NADPH-hemoprotein Reductase Activity Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Iron Ion Binding Protein Binding Nitric Oxide Dioxygenase Activity Electron Carrier Activity FMN Binding Hydrolase Activity Enzyme Binding Iron-cytochrome-c Reductase Activity Flavin Adenine Dinucleotide Binding NADP Binding
	Biological Process	Xenobiotic Metabolic Process Steroid Metabolic Process Coumarin Metabolic Process Drug Metabolic Process Epoxygenase P450 Pathway Exogenous Drug Catabolic Process Small Molecule Metabolic Process Coumarin Catabolic Process Oxidation-reduction Process	Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Response To Nutrient Carnitine Metabolic Process Flavonoid Metabolic Process Internal Peptidyl-lysine Acetylation Fatty Acid Oxidation Positive Regulation Of Chondrocyte Differentiation Positive Regulation Of Monooxygenase Activity Response To Drug Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Nitrate Catabolic Process Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Smoothened Signaling Pathway Nitric Oxide Catabolic Process Oxidation-reduction Process Negative Regulation Of Lipase Activity Demethylation Cellular Response To Follicle-stimulating Hormone Stimulus Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Steroid Hormone Biosynthetic Process Cellular Organofluorine Metabolic Process
Pathways		Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Metabolic disorders of biological oxidation enzymes Phase 1 - Functionalization of compounds Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Cytochrome P450 - arranged by substrate type CYP2E1 reactions Biological oxidations Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective FMO3 causes Trimethylaminuria (TMAU) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Defective CYP1B1 causes Glaucoma Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Xenobiotics Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
Drugs			Flavin-Adenine Dinucleotide Riboflavin Monophosphate 2\'-Monophosphoadenosine 5\'-Diphosphoribose
Diseases
GWAS		Chronic obstructive pulmonary disease ( 22080838) Smoking behavior ( 23049750 20418888 20418890)
Protein-Protein Interactions		2 interactors: CYB5A POR	14 interactors: CYB5A CYP17A1 CYP1A2 CYP2A6 CYP2C19 CYP2C9 CYP2D6 CYP2E1 CYP3A4 FANCC HMOX1 RABEPK STAT1 XRCC6
Entrez ID		1548	5447
HPRD ID		00420	00485
Ensembl ID		ENSG00000255974	ENSG00000127948
Uniprot IDs		P11509	E7EVY7 F5H468 P16435
PDB IDs		1Z10 1Z11 2FDU 2FDV 2FDW 2FDY 3EBS 3T3Q 3T3R 4EJJ	1B1C 3FJO 3QE2 3QFC 3QFR 3QFS 3QFT
Enriched GO Terms of Interacting Partners?		Cellular Organofluorine Metabolic Process Nitric Oxide Catabolic Process Nitrate Catabolic Process Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Nitrate Metabolic Process Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Cholesterol Metabolic Process Positive Regulation Of Steroid Hormone Biosynthetic Process Positive Regulation Of Hormone Biosynthetic Process L-ascorbic Acid Metabolic Process Carnitine Metabolic Process Cellular Response To Follicle-stimulating Hormone Stimulus Amino-acid Betaine Metabolic Process Negative Regulation Of Lipase Activity Regulation Of Cholesterol Biosynthetic Process Response To Follicle-stimulating Hormone Carboxylic Acid Metabolic Process Cellular Response To Gonadotropin Stimulus Flavonoid Metabolic Process Positive Regulation Of Monooxygenase Activity Regulation Of Hormone Biosynthetic Process Positive Regulation Of Steroid Metabolic Process Nitric Oxide Metabolic Process Organic Acid Metabolic Process Regulation Of Cholesterol Metabolic Process Reactive Nitrogen Species Metabolic Process Positive Regulation Of Chondrocyte Differentiation Regulation Of Hormone Metabolic Process Positive Regulation Of Oxidoreductase Activity Response To Gonadotropin Positive Regulation Of Cartilage Development Positive Regulation Of Smoothened Signaling Pathway Oxidation-reduction Process Response To Cadmium Ion Positive Regulation Of Lipid Biosynthetic Process Demethylation Fatty Acid Oxidation Lipid Oxidation Regulation Of Chondrocyte Differentiation Regulation Of Steroid Biosynthetic Process Regulation Of Oxidoreductase Activity Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Water-soluble Vitamin Metabolic Process Regulation Of Cartilage Development Regulation Of Smoothened Signaling Pathway Regulation Of Steroid Metabolic Process Regulation Of Organ Growth Reactive Oxygen Species Metabolic Process Vitamin Metabolic Process	Monoterpenoid Metabolic Process Exogenous Drug Catabolic Process Drug Catabolic Process Drug Metabolic Process Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Response To Xenobiotic Stimulus Epoxygenase P450 Pathway Steroid Metabolic Process Arachidonic Acid Metabolic Process Response To Drug Icosanoid Metabolic Process Unsaturated Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Isoprenoid Metabolic Process Oxidative Demethylation Oxidation-reduction Process Omega-hydroxylase P450 Pathway Fatty Acid Metabolic Process Alkaloid Metabolic Process Carboxylic Acid Metabolic Process Demethylation Small Molecule Metabolic Process Organic Acid Metabolic Process Response To Inorganic Substance Lipid Metabolic Process Monocarboxylic Acid Metabolic Process Cellular Lipid Metabolic Process Alkaloid Catabolic Process Catabolic Process Response To Reactive Oxygen Species Heterocycle Metabolic Process Response To Cadmium Ion Response To Stimulus Coumarin Metabolic Process Cellular Response To Stimulus Dibenzo-p-dioxin Metabolic Process Cellular Response To Cadmium Ion Response To Oxidative Stress Steroid Catabolic Process Cellular Metabolic Process Androgen Metabolic Process Porphyrin-containing Compound Metabolic Process Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Cellular Organofluorine Metabolic Process Negative Regulation Of Macrophage Fusion Oxidative Deethylation Response To Acetate Toxin Biosynthetic Process Response To Lipopolysaccharide
Tagcloud ?		able analogues antitumour asn297 benzopsoralen better carried cofactor compounds discussed docking enzymes evaluate haem inhibitory interact ion iron mb231 mda molecules new proliferative relationship sup synthesized tcc terms tumourtumour	5c 7h adjuvant aluminiumphosphate bactericidal class deoxycholate donors engineered extraction final formulated genetically meningococcal mixed omps omv outer p1 pora prepared represent safe serogroup served strains vaccine vaccines vesicles
Tagcloud (Difference) ?		able analogues antitumour asn297 benzopsoralen better carried cofactor compounds discussed docking enzymes evaluate haem inhibitory interact ion iron mb231 mda molecules new proliferative relationship sup synthesized tcc terms tumourtumour	5c 7h adjuvant aluminiumphosphate bactericidal class deoxycholate donors engineered extraction final formulated genetically meningococcal mixed omps omv outer p1 pora prepared represent safe serogroup served strains vaccine vaccines vesicles
Tagcloud (Intersection) ?