CYP2A6

Gene Name		cytochrome P450, family 2, subfamily A, polypeptide 6
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Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Cytoplasmic Microtubule Intracellular Membrane-bounded Organelle
	Molecular Function	Iron Ion Binding Coumarin 7-hydroxylase Activity Arachidonic Acid Epoxygenase Activity Steroid Hydroxylase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Oxygen Binding Enzyme Binding Heme Binding
	Biological Process	Xenobiotic Metabolic Process Steroid Metabolic Process Coumarin Metabolic Process Drug Metabolic Process Epoxygenase P450 Pathway Exogenous Drug Catabolic Process Small Molecule Metabolic Process Coumarin Catabolic Process Oxidation-reduction Process
Pathways		Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Metabolic disorders of biological oxidation enzymes Phase 1 - Functionalization of compounds Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Cytochrome P450 - arranged by substrate type CYP2E1 reactions Biological oxidations Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective FMO3 causes Trimethylaminuria (TMAU) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Defective CYP1B1 causes Glaucoma Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Xenobiotics Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease ( 22080838) Smoking behavior ( 23049750 20418888 20418890)
Protein-protein Interactions		2 interactors: CYB5A POR
Entrez ID		1548
HPRD ID		00420
Ensembl ID		ENSG00000255974
Uniprot IDs		P11509
PDB IDs		1Z10 1Z11 2FDU 2FDV 2FDW 2FDY 3EBS 3T3Q 3T3R 4EJJ
Enriched GO Terms of Interacting Partners?		Cellular Organofluorine Metabolic Process Nitric Oxide Catabolic Process Nitrate Catabolic Process Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Nitrate Metabolic Process Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Cholesterol Metabolic Process Positive Regulation Of Steroid Hormone Biosynthetic Process Positive Regulation Of Hormone Biosynthetic Process L-ascorbic Acid Metabolic Process Carnitine Metabolic Process Cellular Response To Follicle-stimulating Hormone Stimulus Amino-acid Betaine Metabolic Process Negative Regulation Of Lipase Activity Regulation Of Cholesterol Biosynthetic Process Response To Follicle-stimulating Hormone Carboxylic Acid Metabolic Process Cellular Response To Gonadotropin Stimulus Flavonoid Metabolic Process Positive Regulation Of Monooxygenase Activity Regulation Of Hormone Biosynthetic Process Positive Regulation Of Steroid Metabolic Process Nitric Oxide Metabolic Process Organic Acid Metabolic Process Regulation Of Cholesterol Metabolic Process Reactive Nitrogen Species Metabolic Process Positive Regulation Of Chondrocyte Differentiation Regulation Of Hormone Metabolic Process Positive Regulation Of Oxidoreductase Activity Response To Gonadotropin Positive Regulation Of Cartilage Development Positive Regulation Of Smoothened Signaling Pathway Oxidation-reduction Process Response To Cadmium Ion Positive Regulation Of Lipid Biosynthetic Process Demethylation Fatty Acid Oxidation Lipid Oxidation Regulation Of Chondrocyte Differentiation Regulation Of Steroid Biosynthetic Process Regulation Of Oxidoreductase Activity Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Water-soluble Vitamin Metabolic Process Regulation Of Cartilage Development Regulation Of Smoothened Signaling Pathway Regulation Of Steroid Metabolic Process Regulation Of Organ Growth Reactive Oxygen Species Metabolic Process Vitamin Metabolic Process
Tagcloud ?		able analogues antitumour asn297 benzopsoralen better carried cofactor compounds discussed docking enzymes evaluate haem inhibitory interact ion iron mb231 mda molecules new proliferative relationship sup synthesized tcc terms tumourtumour