CYP1A1 and CYB5A

Number of citations of the paper that reports this interaction (PMID 6102994)
10

Data Source:
HPRD (in vitro)

		CYP1A1	CYB5A
Gene Name		cytochrome P450, family 1, subfamily A, polypeptide 1	cytochrome b5 type A (microsomal)
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Membrane	Mitochondrial Outer Membrane Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Iron Ion Binding Steroid Hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Diphenols And Related Substances As Donors Flavonoid 3'-monooxygenase Activity Oxygen Binding Enzyme Binding Heme Binding Demethylase Activity Aromatase Activity Vitamin D 24-hydroxylase Activity	Aldo-keto Reductase (NADP) Activity Cytochrome-c Oxidase Activity Enzyme Binding Heme Binding Metal Ion Binding
	Biological Process	Response To Hypoxia Porphyrin-containing Compound Metabolic Process Xenobiotic Metabolic Process Aging Cell Proliferation Amine Metabolic Process Response To Wounding Response To Virus Response To Nematode Response To Herbicide Embryo Development Ending In Birth Or Egg Hatching Coumarin Metabolic Process Flavonoid Metabolic Process Response To Iron(III) Ion Insecticide Metabolic Process Drug Metabolic Process Dibenzo-p-dioxin Catabolic Process Arachidonic Acid Metabolic Process Epoxygenase P450 Pathway Response To Food Response To Lipopolysaccharide Response To Vitamin A Response To Immobilization Stress Vitamin D Metabolic Process Response To Drug 9-cis-retinoic Acid Biosynthetic Process Camera-type Eye Development Cellular Lipid Metabolic Process Small Molecule Metabolic Process Response To Antibiotic Response To Arsenic-containing Substance Digestive Tract Development Hydrogen Peroxide Biosynthetic Process Response To Hyperoxia Oxidation-reduction Process Maternal Process Involved In Parturition Hepatocyte Differentiation Demethylation Cellular Response To Organic Cyclic Compound Omega-hydroxylase P450 Pathway Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle	Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process L-ascorbic Acid Metabolic Process Small Molecule Metabolic Process Response To Cadmium Ion Oxidation-reduction Process Hydrogen Ion Transmembrane Transport
Pathways		PPARA activates gene expression Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Metabolism of lipids and lipoproteins Metabolic disorders of biological oxidation enzymes Phase 1 - Functionalization of compounds Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Arachidonic acid metabolism Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Cytochrome P450 - arranged by substrate type Biological oxidations Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective FMO3 causes Trimethylaminuria (TMAU) Fatty acid, triacylglycerol, and ketone body metabolism Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Defective CYP1B1 causes Glaucoma Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Xenobiotics Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3) Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective GIF causes intrinsic factor deficiency Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Vitamin C (ascorbate) metabolism Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective MMAA causes methylmalonic aciduria type cblA Defective CUBN causes hereditary megaloblastic anemia 1 Defective AMN causes hereditary megaloblastic anemia 1 Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Defects in cobalamin (B12) metabolism Defects in vitamin and cofactor metabolism
Drugs			Heme Dimethyl Propionate Ester Heme
Diseases
GWAS		Caffeine consumption ( 21490707) Coffee consumption ( 21876539 21357676) Diastolic blood pressure ( 19430483 21909115) Systolic blood pressure ( 21909115)
Protein-Protein Interactions		2 interactors: CMTM5 CYB5A	15 interactors: CYB5R3 CYCS CYP17A1 CYP1A1 CYP1A2 CYP2A6 CYP2D6 CYP2E1 CYP2W1 CYP3A4 CYP4A11 CYP4F2 POR SCD UGT1A4
Entrez ID		1543	1528
HPRD ID		00148	08941
Ensembl ID		ENSG00000140465	ENSG00000166347
Uniprot IDs		A0N0X8 A4F4K4 E7EMT5 P04798 Q5J9B1	P00167
PDB IDs		4I8V	2I96
Enriched GO Terms of Interacting Partners?		L-ascorbic Acid Metabolic Process Negative Regulation Of Myoblast Differentiation Regulation Of Myoblast Differentiation Negative Regulation Of Muscle Cell Differentiation Response To Cadmium Ion	Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Response To Xenobiotic Stimulus Drug Metabolic Process Epoxygenase P450 Pathway Oxidation-reduction Process Exogenous Drug Catabolic Process Organic Acid Metabolic Process Small Molecule Metabolic Process Drug Catabolic Process Arachidonic Acid Metabolic Process Carboxylic Acid Metabolic Process Fatty Acid Metabolic Process Icosanoid Metabolic Process Monocarboxylic Acid Metabolic Process Unsaturated Fatty Acid Metabolic Process Lipid Metabolic Process Long-chain Fatty Acid Metabolic Process Steroid Metabolic Process Monoterpenoid Metabolic Process Response To Drug Omega-hydroxylase P450 Pathway Catabolic Process Cellular Lipid Metabolic Process Demethylation Coumarin Metabolic Process Isoprenoid Metabolic Process Dibenzo-p-dioxin Metabolic Process Alkaloid Metabolic Process Toxin Metabolic Process Oxidative Demethylation Flavonoid Metabolic Process Vitamin Metabolic Process Alkaloid Catabolic Process Pressure Natriuresis Leukotriene B4 Catabolic Process Cellular Metabolic Process Cellular Response To Stimulus Porphyrin-containing Compound Metabolic Process Positive Regulation Of Steroid Hormone Biosynthetic Process Long-chain Fatty Acid Catabolic Process Response To Herbicide Heterocycle Metabolic Process Hydrogen Peroxide Biosynthetic Process Lipid Catabolic Process Cellular Ketone Metabolic Process Positive Regulation Of Hormone Biosynthetic Process Tetrapyrrole Metabolic Process Lipid Biosynthetic Process Vitamin D Metabolic Process
Tagcloud ?		acetone androgenic benzophenone bp cho desmethylated dexamethasone dioh estrogenic hair hydroxy hydroxylated incubated metabolite metabolites metabolized methoxybenzophenone methylcholanthrene microsomes nadph oh p450 phenobarbital stronger sunscreen trihydroxybenzophenone trioh ultraviolet	administering anxa1 c4bpalpha cox2 cpla2alpha crip1 ctsl1 endorses eva1 gstp1 hgd il6st interferes levonorgestrel lng loc90133 maoa mifepristone ovulatory paep receptive receptivity s100a4 sat1 serpinb9 slc25a29 slc39a14 tgm2 unproven
Tagcloud (Difference) ?		acetone androgenic benzophenone bp cho desmethylated dexamethasone dioh estrogenic hair hydroxy hydroxylated incubated metabolite metabolites metabolized methoxybenzophenone methylcholanthrene microsomes nadph oh p450 phenobarbital stronger sunscreen trihydroxybenzophenone trioh ultraviolet	administering anxa1 c4bpalpha cox2 cpla2alpha crip1 ctsl1 endorses eva1 gstp1 hgd il6st interferes levonorgestrel lng loc90133 maoa mifepristone ovulatory paep receptive receptivity s100a4 sat1 serpinb9 slc25a29 slc39a14 tgm2 unproven
Tagcloud (Intersection) ?