CYP1A1

Description		cytochrome P450 family 1 subfamily A member 1
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Inner Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Catalytic Activity Monooxygenase Activity Iron Ion Binding Protein Binding Arachidonate Monooxygenase Activity Steroid Hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Diphenols And Related Substances As Donors Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Flavonoid 3'-monooxygenase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Lyase Activity Oxygen Binding Enzyme Binding Heme Binding Hsp70 Protein Binding Demethylase Activity Metal Ion Binding Hsp90 Protein Binding Vitamin D 24-hydroxylase Activity Estrogen 16-alpha-hydroxylase Activity Estrogen 2-hydroxylase Activity Long-chain Fatty Acid Omega-hydroxylase Activity Hydroperoxy Icosatetraenoate Dehydratase Activity Long-chain Fatty Acid Omega-1 Hydroxylase Activity
	Biological Process	Response To Hypoxia Long-chain Fatty Acid Metabolic Process Liver Development Lipid Hydroxylation Lipid Metabolic Process Fatty Acid Metabolic Process Steroid Biosynthetic Process Steroid Catabolic Process Porphyrin-containing Compound Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Estrogen Metabolic Process Amine Metabolic Process Toxin Metabolic Process Response To Xenobiotic Stimulus Response To Nematode Response To Herbicide Response To Toxic Substance Ethylene Metabolic Process Coumarin Metabolic Process Flavonoid Metabolic Process Response To Iron(III) Ion Insecticide Metabolic Process Dibenzo-p-dioxin Metabolic Process Phenol-containing Compound Metabolic Process Dibenzo-p-dioxin Catabolic Process Epoxygenase P450 Pathway Response To Food Response To Lipopolysaccharide Response To Vitamin A Response To Genistein Response To Immobilization Stress Xenobiotic Catabolic Process Vitamin D Metabolic Process Hormone Metabolic Process Retinol Metabolic Process Long-chain Fatty Acid Biosynthetic Process 9-cis-retinoic Acid Biosynthetic Process Camera-type Eye Development Nitric Oxide Metabolic Process Response To Arsenic-containing Substance Digestive Tract Development Tissue Remodeling Hydrogen Peroxide Biosynthetic Process Response To Hyperoxia Maternal Process Involved In Parturition Hepatocyte Differentiation Cellular Response To Copper Ion Omega-hydroxylase P450 Pathway Olefinic Compound Metabolic Process Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Response To Diphenyl Ether Response To Aroclor 1254 Response To 2,3,7,8-tetrachlorodibenzodioxine Response To 3-methylcholanthrene
Pathways		PPARA activates gene expression Xenobiotics Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Biosynthesis of protectins
Drugs		2-Methoxyestradiol Indirubin Nabiximols
Diseases
GWAS		Bitter beverage consumption ( 31046077) Bitter non-alcoholic beverage consumption ( 31046077) Blood urea nitrogen levels ( 31152163) Caffeine consumption ( 21490707) Caffeine consumption from coffee ( 33287642) Caffeine consumption from coffee or tea ( 33287642) Caffeine consumption from tea ( 33287642) Caffeine metabolism (plasma 1,3,7-trimethylxanthine (caffeine) level) ( 27702941) Caffeine metabolism (plasma 1,3-dimethylxanthine (theophylline) level) ( 27702941) Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio) ( 27702941) Clozapine concentration in schizophrenia ( 32555152) Coffee consumption ( 21357676 31046077 21876539 25288136) Coffee consumption (cups per day) ( 31837886 25288136) Diastolic blood pressure ( 19430483 21909115 26390057 27618452 28739976) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Estimated glomerular filtration rate ( 31451708 31152163) Estimated glomerular filtration rate in non-diabetics ( 31451708) Microalbuminuria ( 31511532) Plasma clozapine levels in treatment-resistant schizophrenia ( 30922102) Platelet distribution width ( 27863252) Relative carbohydrate intake ( 32393786) Sweet beverage consumption ( 31046077) Systolic blood pressure ( 28739976 21909115 27618452) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Tea consumption ( 31046077) Urate levels ( 31578528) Urinary albumin excretion ( 30220432) Urinary albumin excretion (no hypertensive medication) ( 30220432) Urinary albumin-to-creatinine ratio ( 31511532 31630189 30910378) Urinary potassium excretion ( 31409800) Urinary sodium excretion ( 31409800)
Novel Interacting Genes		8 novel interacting genes: AKR7A3 CELF6 CEMIP COX5A CYP1A2 FBXW5 VAMP4 ZNF189
Interacting Genes		2 interacting genes: CMTM5 CYB5A
Entrez ID		1543
HPRD ID		00148
Ensembl ID		ENSG00000140465
Uniprot IDs		A0N0X8 E7EMT5 P04798
PDB IDs		4I8V 6DWM 6DWN 6O5Y 6UDL 6UDM
Enriched GO Terms of Interacting Partners?		Aflatoxin Metabolic Process Electron Transfer Activity Toxin Metabolic Process Secondary Metabolic Process Toxin Biosynthetic Process Heme Binding Cellular Respiration Demethylase Activity Caffeine Oxidase Activity Dibenzo-p-dioxin Metabolic Process Synaptic Vesicle To Endosome Fusion Presynaptic Endosome Membrane NADP+ Binding Toxin Catabolic Process Aflatoxin Catabolic Process Hyaluronan Biosynthetic Process Positive Regulation Of Protein Kinase C Activity
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