CYP1A1

Gene Name		cytochrome P450, family 1, subfamily A, polypeptide 1
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Gene Ontology Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Membrane
	Molecular Function	Iron Ion Binding Steroid Hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Diphenols And Related Substances As Donors Flavonoid 3'-monooxygenase Activity Oxygen Binding Enzyme Binding Heme Binding Demethylase Activity Aromatase Activity Vitamin D 24-hydroxylase Activity
	Biological Process	Response To Hypoxia Porphyrin-containing Compound Metabolic Process Xenobiotic Metabolic Process Aging Cell Proliferation Amine Metabolic Process Response To Wounding Response To Virus Response To Nematode Response To Herbicide Embryo Development Ending In Birth Or Egg Hatching Coumarin Metabolic Process Flavonoid Metabolic Process Response To Iron(III) Ion Insecticide Metabolic Process Drug Metabolic Process Dibenzo-p-dioxin Catabolic Process Arachidonic Acid Metabolic Process Epoxygenase P450 Pathway Response To Food Response To Lipopolysaccharide Response To Vitamin A Response To Immobilization Stress Vitamin D Metabolic Process Response To Drug 9-cis-retinoic Acid Biosynthetic Process Camera-type Eye Development Cellular Lipid Metabolic Process Small Molecule Metabolic Process Response To Antibiotic Response To Arsenic-containing Substance Digestive Tract Development Hydrogen Peroxide Biosynthetic Process Response To Hyperoxia Oxidation-reduction Process Maternal Process Involved In Parturition Hepatocyte Differentiation Demethylation Cellular Response To Organic Cyclic Compound Omega-hydroxylase P450 Pathway Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		PPARA activates gene expression Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Metabolism of lipids and lipoproteins Metabolic disorders of biological oxidation enzymes Phase 1 - Functionalization of compounds Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Arachidonic acid metabolism Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Cytochrome P450 - arranged by substrate type Biological oxidations Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective FMO3 causes Trimethylaminuria (TMAU) Fatty acid, triacylglycerol, and ketone body metabolism Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Defective CYP1B1 causes Glaucoma Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Xenobiotics Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3) Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS		Caffeine consumption ( 21490707) Coffee consumption ( 21876539 21357676) Diastolic blood pressure ( 19430483 21909115) Systolic blood pressure ( 21909115)
Protein-protein Interactions		2 interactors: CMTM5 CYB5A
Entrez ID		1543
HPRD ID		00148
Ensembl ID		ENSG00000140465
Uniprot IDs		A0N0X8 A4F4K4 E7EMT5 P04798 Q5J9B1
PDB IDs		4I8V
Enriched GO Terms of Interacting Partners?		L-ascorbic Acid Metabolic Process Negative Regulation Of Myoblast Differentiation Regulation Of Myoblast Differentiation Negative Regulation Of Muscle Cell Differentiation Response To Cadmium Ion
Tagcloud ?		acetone androgenic benzophenone bp cho desmethylated dexamethasone dioh estrogenic hair hydroxy hydroxylated incubated metabolite metabolites metabolized methoxybenzophenone methylcholanthrene microsomes nadph oh p450 phenobarbital stronger sunscreen trihydroxybenzophenone trioh ultraviolet