CYP1A1 and CMTM5

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		CYP1A1	CMTM5
Gene Name		cytochrome P450, family 1, subfamily A, polypeptide 1	CKLF-like MARVEL transmembrane domain containing 5
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Membrane	Extracellular Space Integral Component Of Membrane
	Molecular Function	Iron Ion Binding Steroid Hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Diphenols And Related Substances As Donors Flavonoid 3'-monooxygenase Activity Oxygen Binding Enzyme Binding Heme Binding Demethylase Activity Aromatase Activity Vitamin D 24-hydroxylase Activity	Cytokine Activity
	Biological Process	Response To Hypoxia Porphyrin-containing Compound Metabolic Process Xenobiotic Metabolic Process Aging Cell Proliferation Amine Metabolic Process Response To Wounding Response To Virus Response To Nematode Response To Herbicide Embryo Development Ending In Birth Or Egg Hatching Coumarin Metabolic Process Flavonoid Metabolic Process Response To Iron(III) Ion Insecticide Metabolic Process Drug Metabolic Process Dibenzo-p-dioxin Catabolic Process Arachidonic Acid Metabolic Process Epoxygenase P450 Pathway Response To Food Response To Lipopolysaccharide Response To Vitamin A Response To Immobilization Stress Vitamin D Metabolic Process Response To Drug 9-cis-retinoic Acid Biosynthetic Process Camera-type Eye Development Cellular Lipid Metabolic Process Small Molecule Metabolic Process Response To Antibiotic Response To Arsenic-containing Substance Digestive Tract Development Hydrogen Peroxide Biosynthetic Process Response To Hyperoxia Oxidation-reduction Process Maternal Process Involved In Parturition Hepatocyte Differentiation Demethylation Cellular Response To Organic Cyclic Compound Omega-hydroxylase P450 Pathway Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle	Chemotaxis Negative Regulation Of Myoblast Differentiation
Pathways		PPARA activates gene expression Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Metabolism of lipids and lipoproteins Metabolic disorders of biological oxidation enzymes Phase 1 - Functionalization of compounds Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Arachidonic acid metabolism Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Cytochrome P450 - arranged by substrate type Biological oxidations Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective FMO3 causes Trimethylaminuria (TMAU) Fatty acid, triacylglycerol, and ketone body metabolism Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Defective CYP1B1 causes Glaucoma Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Xenobiotics Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3) Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS		Caffeine consumption ( 21490707) Coffee consumption ( 21876539 21357676) Diastolic blood pressure ( 19430483 21909115) Systolic blood pressure ( 21909115)
Protein-Protein Interactions		2 interactors: CMTM5 CYB5A	46 interactors: AACS ACSF2 ALDH18A1 APOA1 ARMC9 C12orf10 CPLX1 CYP1A1 DDA1 FAM114A1 FARS2 GAD1 GAD2 GLTP GOLGA2P10 GTF3C1 KIAA0368 LMO2 MCEE MTERF3 NDRG4 PITPNC1 PLIN3 PPIF PPP2R3C PTPN9 RBFA RMDN2 RNF185 RSRC2 SDCBP SH3GLB1 SHMT2 SNX1 SPATA8 SPG21 SSX3 SUCLA2 SYNE4 TIMM44 TPD52L3 TTPA TUBB TUFM VARS2 ZNF391
Entrez ID		1543	116173
HPRD ID		00148	06986
Ensembl ID		ENSG00000140465	ENSG00000166091
Uniprot IDs		A0N0X8 A4F4K4 E7EMT5 P04798 Q5J9B1	C9JAI6 Q96DZ9
PDB IDs		4I8V
Enriched GO Terms of Interacting Partners?		L-ascorbic Acid Metabolic Process Negative Regulation Of Myoblast Differentiation Regulation Of Myoblast Differentiation Negative Regulation Of Muscle Cell Differentiation Response To Cadmium Ion	Carboxylic Acid Metabolic Process Succinate Metabolic Process Organic Acid Metabolic Process Glutamate Decarboxylation To Succinate Glutamate Metabolic Process Dicarboxylic Acid Metabolic Process Small Molecule Metabolic Process Glutamate Catabolic Process Cellular Amino Acid Metabolic Process Dicarboxylic Acid Catabolic Process Neurotransmitter Biosynthetic Process Response To Nutrient Neurotransmitter Secretion Response To Arsenic-containing Substance Alpha-amino Acid Metabolic Process Neurotransmitter Metabolic Process Cellular Metabolic Process Cellular Amino Acid Biosynthetic Process Response To Drug Regulation Of Neurotransmitter Levels Fatty Acid Metabolic Process Monocarboxylic Acid Metabolic Process Ornithine Biosynthetic Process Regulation Of Proton-transporting ATPase Activity, Rotational Mechanism Succinyl-CoA Pathway Negative Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Establishment Of Blood-brain Barrier L-methylmalonyl-CoA Metabolic Process Dibenzo-p-dioxin Catabolic Process Cofactor Metabolic Process Neurotransmitter Transport Establishment Of Localization In Cell Porphyrin-containing Compound Metabolic Process Valyl-tRNA Aminoacylation Negative Regulation Of Oxidative Phosphorylation Uncoupler Activity Protein-pyridoxal-5-phosphate Linkage Uroporphyrinogen III Biosynthetic Process Negative Regulation Of Interleukin-1 Beta Secretion Regulation Of Establishment Of Blood-brain Barrier
Tagcloud ?		acetone androgenic benzophenone bp cho desmethylated dexamethasone dioh estrogenic hair hydroxy hydroxylated incubated metabolite metabolites metabolized methoxybenzophenone methylcholanthrene microsomes nadph oh p450 phenobarbital stronger sunscreen trihydroxybenzophenone trioh ultraviolet	author bio chance chip chosen cyclin d1 discover egfr epithelium her2 ihc insure makes manners next partner pc3 performance plasmid plays prostate regulated relationship stream traditional transduction transfection whether
Tagcloud (Difference) ?		acetone androgenic benzophenone bp cho desmethylated dexamethasone dioh estrogenic hair hydroxy hydroxylated incubated metabolite metabolites metabolized methoxybenzophenone methylcholanthrene microsomes nadph oh p450 phenobarbital stronger sunscreen trihydroxybenzophenone trioh ultraviolet	author bio chance chip chosen cyclin d1 discover egfr epithelium her2 ihc insure makes manners next partner pc3 performance plasmid plays prostate regulated relationship stream traditional transduction transfection whether
Tagcloud (Intersection) ?