CYLD and OPTN

Number of citations of the paper that reports this interaction (PMID 21408173)
10

Data Source:
BioGRID (pull down)

		CYLD	OPTN
Gene Name		cylindromatosis (turban tumor syndrome)	optineurin
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Gene Ontology Annotations	Cellular Component	Nucleoplasm Centrosome Spindle Cytosol Cytoplasmic Microtubule Midbody Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Ciliary Basal Body Perinuclear Region Of Cytoplasm Ciliary Tip	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Autophagic Vacuole Golgi Apparatus Trans-Golgi Network Cytosol Cytoplasmic Membrane-bounded Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome
	Molecular Function	Structural Constituent Of Ribosome Ubiquitin-specific Protease Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Lys63-specific Deubiquitinase Activity Proline-rich Region Binding	Protein Binding Protein C-terminus Binding Rab GTPase Binding Polyubiquitin Binding K63-linked Polyubiquitin Binding
	Biological Process	Cytoplasmic Translation Ubiquitin-dependent Protein Catabolic Process Cell Cycle Regulation Of Mitotic Cell Cycle Wnt Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Type I Interferon Production Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Negative Regulation Of NF-kappaB Import Into Nucleus Innate Immune Response Negative Regulation Of T Cell Differentiation Necroptotic Process Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Microtubule Cytoskeleton Organization Protein K63-linked Deubiquitination Negative Regulation Of Canonical Wnt Signaling Pathway Ripoptosome Assembly Involved In Necroptotic Process Regulation Of Cilium Assembly Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway	Protein Targeting To Golgi G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Negative Regulation Of Receptor Recycling Golgi Organization Signal Transduction Cell Death Macroautophagy Golgi To Plasma Membrane Protein Transport Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Defense Response To Gram-negative Bacterium Golgi Ribbon Formation
Pathways		RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Negative regulators of RIG-I/MDA5 signaling Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways NOD1/2 Signaling Pathway Innate Immune System	G2/M Transition Mitotic G2-G2/M phases Regulation of PLK1 Activity at G2/M Transition Cell Cycle, Mitotic
Drugs
Diseases
GWAS		Bone mineral density ( 22504420) Crohn's disease ( 22412388) Leprosy ( 22019778)	Paget's disease ( 21623375 20436471)
Protein-Protein Interactions		15 interactors: AKT1 AURKB DDX58 HDAC6 IKBKG ITCH MAPRE1 OPTN PPP2R4 TRAF2 TRAF6 TRAF7 TRAIP TUBA1A UBE2S	36 interactors: CALM1 CCDC53 CDC23 CYLD DAZAP2 EPS15 FAM178A FLII FOS GNAS GRM1 GTF3A HACE1 HTT MAP1LC3A MPP1 MYO6 PIAS4 RAB10 RAB11A RAB11B RAB12 RAB14 RAB25 RAB8A RNF11 SQSTM1 TBC1D15 TBC1D17 TBK1 TNIP1 UBC UQCRQ ZNF329 ZNF398 ZNF670
Entrez ID		1540	10133
HPRD ID		05427	03891
Ensembl ID		ENSG00000083799	ENSG00000123240
Uniprot IDs		Q9NQC7	Q96CV9
PDB IDs		1IXD 1WHL 1WHM 2VHF	2LO4 2LUE 3VTV 3VTW
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein K63-linked Ubiquitination Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Polyubiquitination Cell Death Death Regulation Of Cell Death Positive Regulation Of Innate Immune Response Mitotic Cell Cycle Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Mitotic Cell Cycle Positive Regulation Of Protein Metabolic Process Immune Response-regulating Signaling Pathway Regulation Of Innate Immune Response Activation Of NF-kappaB-inducing Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of NIK/NF-kappaB Signaling Regulation Of Apoptotic Process Apoptotic Process Positive Regulation Of Programmed Cell Death Protein Catabolic Process Programmed Cell Death Regulation Of MAPK Cascade Positive Regulation Of Cell Death NIK/NF-kappaB Signaling Cell Cycle Process Regulation Of Protein Metabolic Process Regulation Of NIK/NF-kappaB Signaling Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of JNK Cascade Cellular Protein Modification Process Protein K29-linked Ubiquitination Regulation Of Stress-activated MAPK Cascade Regulation Of Protein Localization Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Innate Immune Response Intracellular Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling	Endosomal Transport Rab Protein Signal Transduction Membrane Organization Ras Protein Signal Transduction Secretion By Cell Establishment Of Localization In Cell Intracellular Transport Intracellular Signal Transduction Secretion Protein Secretion Cellular Localization Cell Communication Signal Transduction Regulation Of Signaling Protein Transport Vesicle-mediated Transport Signaling Establishment Of Protein Localization Exocytosis Protein Localization Pattern Recognition Receptor Signaling Pathway Cellular Response To Stimulus Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Small GTPase Mediated Signal Transduction Regulation Of Cellular Process Intracellular Protein Transport Positive Regulation Of Metabolic Process Positive Regulation Of Innate Immune Response Establishment Of Organelle Localization Establishment Of Vesicle Localization Vesicle Localization Cellular Protein Catabolic Process Regulation Of Vesicle-mediated Transport Melanosome Transport Regulation Of Intracellular Signal Transduction Pigment Granule Transport Regulation Of I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor Signaling Pathway Establishment Of Melanosome Localization Protein Catabolic Process Regulation Of Innate Immune Response Positive Regulation Of Cellular Metabolic Process Organelle Localization Melanosome Localization Endomembrane System Organization Golgi Vesicle Transport Negative Regulation Of Type I Interferon Production Immune Response-regulating Signaling Pathway Regulation Of Signal Transduction
Tagcloud ?		181b adjacent array assays blot coding colony corroboration deregulated downregulation luciferase micro micrornas mir mirnas mtt oncogenes papillary promoted putative qpcr reporter rnas specimens thyroid tpc1 untranslated utr validate	advocate agenda ast cms comes competence consent continuum controversies educated ilda independence informed interpretive ldcop mandated maximize medicaid minimize narrow optimize procurement profession qualifications regulations skill transparent varies veto
Tagcloud (Difference) ?		181b adjacent array assays blot coding colony corroboration deregulated downregulation luciferase micro micrornas mir mirnas mtt oncogenes papillary promoted putative qpcr reporter rnas specimens thyroid tpc1 untranslated utr validate	advocate agenda ast cms comes competence consent continuum controversies educated ilda independence informed interpretive ldcop mandated maximize medicaid minimize narrow optimize procurement profession qualifications regulations skill transparent varies veto
Tagcloud (Intersection) ?