DCLRE1A and ERCC6

Number of citations of the paper that reports this interaction (PubMedID 25505141)
41

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		DCLRE1A	ERCC6
Description		DNA cross-link repair 1A	ERCC excision repair 6, chromatin remodeling factor
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GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm	Nucleus Nucleoplasm Chromosome Nucleolus Transcription Elongation Factor Complex Nuclear Body Site Of DNA Damage B-WICH Complex
	Molecular Function	DNA Binding Damaged DNA Binding Zinc Ion Binding Beta-lactamase Activity Hydrolase Activity 5'-3' DNA Exonuclease Activity Metal Ion Binding	Nucleotide Binding DNA Binding DNA Helicase Activity Chromatin Binding Helicase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Hydrolase Activity ATP Hydrolysis Activity Protein Tyrosine Kinase Activator Activity Sequence-specific DNA Binding RNA Polymerase Binding Chromatin-protein Adaptor Activity ATP-dependent Chromatin Remodeler Activity ATP-dependent DNA Damage Sensor Activity
	Biological Process	DNA Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Damage Response Interstrand Cross-link Repair Cell Division	Single Strand Break Repair DNA Damage Checkpoint Signaling Response To Superoxide Positive Regulation Of Defense Response To Virus By Host DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair Pyrimidine Dimer Repair Chromatin Remodeling Transcription Elongation By RNA Polymerase I Transcription By RNA Polymerase II DNA Damage Response Response To Oxidative Stress JNK Cascade Nervous System Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To UV Response To Toxic Substance Response To X-ray Response To UV-B Response To Gamma Radiation Positive Regulation Of Gene Expression Protein Ubiquitination Neurogenesis Neuron Differentiation Neuron Projection Development Regulation Of DNA-templated Transcription Elongation Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Regulation Of Transcription Elongation By RNA Polymerase II Multicellular Organism Growth DNA Protection Photoreceptor Cell Maintenance Positive Regulation Of DNA Repair Positive Regulation Of Transcription By RNA Polymerase I Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase III Positive Regulation Of Transcription Initiation By RNA Polymerase II Protein Localization To Chromatin Double-strand Break Repair Via Classical Nonhomologous End Joining Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		Fanconi Anemia Pathway	ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression B-WICH complex positively regulates rRNA expression Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER RNA Polymerase I Transcription Initiation
Drugs
Diseases			Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA) Cockayne syndrome Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS			Pulse pressure x alcohol consumption interaction (2df test) ( 29912962)
Interacting Genes		4 interacting genes: ADRB2 ERCC6 PIAS1 TP53BP1	117 interacting genes: ACTR2 ACTR3 ARPC1A ATP5F1C ATP5PO CAVIN1 CCT5 CCT6A CHEK2 CLIC4 COPE CORO1C CSNK2A2 CSNK2B CTSB CUL5 DARS1 DCLRE1A ECHS1 EIF3C EIF3D EIF3F EIF3I EIF3L EIF4A3 ELOA ERCC5 ERCC8 FBLN2 FNDC3B FOSL1 FXR1 FYTTD1 GATAD2B GRPEL1 GTF2E2 GTF2I H2BC3 H3C1 H4C1 HDAC1 HDAC2 HNRNPUL2 HSPA5 HSPA9 HTATSF1 IARS2 IDH3G IWS1 LEO1 MBD3 MORC3 MRPL11 MRPL13 MRPL20 MRPL21 MRPL3 MRPL38 MRPL4 MRPL47 MRPL50 MRPL58 MRPS18B MRPS22 MRPS25 MRPS26 MTA1 MTA2 MTA3 NAP1L1 NONO NPLOC4 PAF1 PARP1 PCNA PFN2 PML POLR2A POLR2H PPIA PSMC5 RBBP7 RCC1 RHOG RNF11 RPL10 RPL13 RPL30 RPL39 RPL5 RPS15 RPS15A RPS24 RPS29 RPS6 SAE1 SDHA SENP2 SF3B3 SLC39A7 SNRPD1 SUMO1 SUMO2 SUPT6H TACO1 TP53 TPR UBA2 UBC UBE2I UQCRC1 UQCRQ USP7 XAB2 XPA XRCC5 ZBTB38
Entrez ID		9937	2074
HPRD ID		08519	00596
Ensembl ID		ENSG00000198924	ENSG00000225830
Uniprot IDs		Q6PJP8	P0DP91 Q03468 Q59FF6
PDB IDs		4B87 5AHR 5NZW 5NZX 5NZY 5Q1J 5Q1K 5Q1L 5Q1M 5Q1N 5Q1O 5Q1P 5Q1Q 5Q1R 5Q1S 5Q1T 5Q1U 5Q1V 5Q1W 5Q1X 5Q1Y 5Q1Z 5Q20 5Q22 5Q23 5Q24 5Q25 5Q26 5Q27 5Q28 5Q29 5Q2A 5Q2B 5Q2C 5Q2D 5Q2E 5Q2F 5Q2G 5Q2H 5Q2I 5Q2J 5Q2K 5Q2L 5Q2M 5Q2N 5Q2O 5Q2P 5Q2Q 5Q2R 5Q2S 5Q2T 5Q2U 5Q2V 5Q2W 5Q2X 5Q2Y 5Q2Z 5Q30 5Q31 5Q32 5Q33 5Q34 5Q35 5Q36 5Q37 5Q38 5Q39 5Q3A 5Q3B 5Q3C 5Q3D 5Q3E 5Q3F 5Q3G 5Q3H 5Q3I 5Q3J 5Q3K 5Q3L 5Q3M 5Q3N 5Q3O 5Q3P 5Q3Q 5Q3R 5Q3S 5Q3T 5Q3U 5Q3V 5Q3W 5Q3X 5Q3Y 5Q3Z 5Q40 5Q41 5Q42 5Q43 5Q44 5Q45 5Q46 5Q47 5Q48 5Q49 5Q4A 5Q4B 5Q4C 5Q4D 5Q4E 5Q4F 5Q4G 5Q4H 5Q4I 5Q4J 5Q4K 5Q4L 5Q4M 5Q4N 5Q4O 5Q4P 5Q4Q 5Q4R 5Q4S 5Q4T 5Q4U 5Q4V 5Q4W 5Q4X 5Q4Y 5Q4Z 5Q50 5Q51 5Q52 5Q53 5Q54 5Q55 5Q56 5Q57 5Q58 5Q59 5Q5A 5Q5B 5Q5C 5Q5D 5Q5E 5Q5F 5Q5G 5Q5H 5Q5I 5Q5J 5Q5K 5Q5L 5Q5M 5Q5N 5Q5O 5Q5P 5Q5Q 5Q5R 5Q5S 5Q5T 5Q5U 5Q5V 5Q5W 5Q5X 5Q5Y 5Q5Z 5Q60 5Q61 5Q62 5Q63 5Q64 5Q65 5Q66 5Q67 5Q68 5Q69 5Q6A 5Q6B 5Q6C 5Q6D 5Q6E 5Q6F 5Q6G 5Q6H 5Q6I 5Q6J 5Q6K 5Q6L 5Q6M 5Q6N 5Q6O 5Q6P 5Q6Q 5Q6R 5Q6S 5Q6T 5Q6U 5Q6V 5Q6W 5Q6X 5Q6Y 5Q6Z 5Q70 5Q71 5Q72 5Q73 5Q74 5Q75 5Q76 5Q77 5Q78 5Q79 5Q7A 5Q7B 5Q7C 5Q7D 5Q7E 5Q7F 5Q7G 5Q7H 5Q7I 5Q7J 5Q7K 5Q7L 5Q7M 5Q7N 5Q7O 5Q7P 5Q7Q 5Q7R 5Q7S 5Q7T 5Q7U 5Q7V 5Q7W 5Q7X 5Q7Y 5Q7Z 5Q80 5Q81 5Q82 5Q83 5Q84 5Q85 5Q86 5Q87 5Q88 5Q89 5Q8A 5Q8B 5Q8C 5Q8D 5Q8E 5Q8F 5Q8G 5Q8H 5Q8I 5Q8J 5Q8K 5Q8L 5Q8M 5Q8N 5Q8O 5Q8P 5Q8Q 5Q8R 5Q8S 5Q8T 5Q8U 5Q8V 5Q8W 5Q8X 5Q8Y 5Q8Z 5Q90 5Q91 5Q92 5Q93 5Q94 5Q95 5Q96 5Q97 5Q98 5Q99 5Q9A 5Q9B 5Q9C 5Q9D 5Q9E 5Q9F 5Q9G 5Q9H 5Q9I 5Q9J 5Q9K 5Q9L 5Q9M 5Q9N 5Q9O 5Q9P 5Q9Q 5Q9R 5Q9S 5Q9T 5Q9U 5Q9V 5Q9W 5Q9X 5Q9Y 5Q9Z 5QA0 5QA1 5QA2 8C8B 8C8D 8C8S 8CEW 8CF0 8CG9	4CVO 6A6I 7OO3 7OOB 7OOP 7OPC 7OPD 8B3D 8B3F 9BZ0 9ER2 9FD2
Enriched GO Terms of Interacting Partners?		Double-strand Break Repair Via Classical Nonhomologous End Joining Double-strand Break Repair Response To X-ray Negative Regulation Of DNA Repair Negative Regulation Of Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Response To Radiation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of DNA Recombination DNA Repair Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Mini Excitatory Postsynaptic Potential Nucleic Acid Metabolic Process Protein Localization To Chromosome DNA Damage Checkpoint Signaling Nucleobase-containing Compound Metabolic Process Fat Cell Differentiation Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Beta2-adrenergic Receptor Activity Regulation Of DNA Recombination Negative Regulation Of DNA Metabolic Process Regulation Of Double-strand Break Repair DNA Metabolic Process DNA Damage Response Response To Ionizing Radiation Signal Transduction In Response To DNA Damage Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Transcription Coregulator Activity Positive Regulation Of Biosynthetic Process Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Beta-adrenergic Receptor Activity Regulation Of DNA Strand Resection Involved In Replication Fork Processing Norepinephrine Binding Histone H4K20me Methyltransferase Activity Response To Psychosocial Stress Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Response To Stress Positive Regulation Of Lipophagy Regulation Of RNA Biosynthetic Process AMPA Selective Glutamate Receptor Signaling Pathway Negative Regulation Of Cell Cycle Phase Transition Regulation Of DNA Repair Positive Regulation Of Metabolic Process	Translation Ribosome Macromolecule Metabolic Process RNA Binding Macromolecule Biosynthetic Process Structural Constituent Of Ribosome Ribonucleoprotein Complex Mitochondrial Translation Nucleoplasm Protein Metabolic Process NuRD Complex Mitochondrial Large Ribosomal Subunit Mitochondrial Inner Membrane Regulation Of Cell Fate Specification Regulation Of Cell Fate Commitment Nucleus Protein-RNA Complex Assembly Cytosolic Ribosome Ubiquitin Protein Ligase Binding Nucleic Acid Metabolic Process PML Body Regulation Of Stem Cell Differentiation Small Protein Activating Enzyme Binding Cytoplasmic Translation Formation Of Cytoplasmic Translation Initiation Complex Chromosome, Telomeric Region Eukaryotic Translation Initiation Factor 3 Complex Nucleobase-containing Compound Metabolic Process Eukaryotic 48S Preinitiation Complex Protein Sumoylation Mitochondrion Eukaryotic 43S Preinitiation Complex Cytoplasmic Translational Initiation Chromatin Organization Protein-containing Complex Nucleosomal DNA Binding Nucleolus DNA Repair Chromatin Remodeling Mitochondrial Ribosome Regulation Of Protein Metabolic Process Transcription-coupled Nucleotide-excision Repair Translational Initiation Nucleotide-excision Repair Protein-containing Complex Organization DNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Double-strand Break Repair Protein-containing Complex Assembly Chromosome
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