ARF4 and APBA3

Number of citations: 0 (PubMedID 12842896)
Data Source: BioGRID (two hybrid)

		ARF4	APBA3
Name		ARF GTPase 4	amyloid beta precursor protein binding family A member 3
Structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Ruffle Membrane Dendritic Spine Extracellular Exosome Glutamatergic Synapse	Cytoplasm Plasma Membrane Dendritic Spine Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding GTPase Activity Guanyl-nucleotide Exchange Factor Activity Epidermal Growth Factor Receptor Binding Protein Binding GTP Binding NAD+-protein-arginine ADP-ribosyltransferase Activity Phospholipase D Activator Activity	Amyloid-beta Binding Enzyme Inhibitor Activity Protein Binding Enzyme Binding
	Biological Process	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Epidermal Growth Factor Receptor Signaling Pathway Learning Protein Transport Vesicle-mediated Transport Cell Migration Negative Regulation Of Apoptotic Process Apical Protein Localization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Transcription By RNA Polymerase II Response To Axon Injury Regulation Of Synapse Organization Cilium Assembly Dendritic Spine Development Protein Localization To Cilium Regulation Of Postsynapse Organization Regulation Of Cilium Assembly Regulation Of Reactive Oxygen Species Metabolic Process	In Utero Embryonic Development Chemical Synaptic Transmission Regulation Of Gene Expression Protein Transport Negative Regulation Of Catalytic Activity
Pathways		VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic	Neurexins and neuroligins
Drugs		Guanosine-5'-Diphosphate	None
GWAS		No GWAS studies recorded	Serum alkaline phosphatase levels ( 33547301 )
Novel Interactors		2 novel interactors: ITIH1 RHOA	2 novel interactors: BDNF GPX4
Interacting Genes		16 interacting genes: ADRB2 APBA1 APBA2 APBA3 COPS3 DENND1A DENND1B EGFR HNRNPD IKBKG PTEN RAB11FIP3 RCHY1 SDCBP2 SIRPA SUMO2	8 interacting genes: APP ARF3 ARF4 AZI2 BCR EGFR TANK TBKBP1
Entrez ID		378	9546
HPRD ID		03107	05038
Ensembl ID		ENSG00000168374	ENSG00000011132
Uniprot IDs		P18085	O96018
PDB IDs		1Z6X	2YT7 2YT8 5UWS
GO Terms Enriched among Interactors		Dendritic Spine Amyloid-beta Binding Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Size Positive Regulation Of Proteolysis Regulation Of Protein Metabolic Process Endocytic Recycling Regulation Of Macromolecule Metabolic Process In Utero Embryonic Development Chordate Embryonic Development Regulation Of Cell Communication Regulation Of Signaling Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Establishment Of Protein Localization Regulation Of Metabolic Process Chemical Synaptic Transmission Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Trans-synaptic Signaling Synaptic Signaling Regulation Of Protein Modification Process Vesicle-mediated Transport To The Plasma Membrane Phosphatidylinositol Phosphate Binding Cerebral Cortex Cell Migration Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Cellular Localization Regulation Of Gene Expression Protein Transport Regulation Of Proteolysis Establishment Of Localization In Cell Protein Homodimerization Activity Cellular Response To Estradiol Stimulus Enzyme Binding Regulation Of Macromolecule Biosynthetic Process Response To Electrical Stimulus Positive Regulation Of Metabolic Process Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Mini Excitatory Postsynaptic Potential Intracellular Transport Presynaptic Modulation Of Chemical Synaptic Transmission Locomotory Behavior	Serine/threonine Protein Kinase Complex Type I Interferon-mediated Signaling Pathway Interferon-mediated Signaling Pathway Collateral Sprouting Response To External Biotic Stimulus Cell Surface Receptor Signaling Pathway Protein-containing Complex Regulation Of Reactive Oxygen Species Metabolic Process Dendritic Spine Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Synapse Organization Regulation Of Response To Calcium Ion Learning Or Memory Perinuclear Region Of Cytoplasm Amylin Binding Positive Regulation Of Toll Signaling Pathway Dendrite Development Signal Transduction Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Epidermal Growth Factor Receptor Signaling Pathway Multivesicular Body, Internal Vesicle Lumen Defense Response To Virus Positive Regulation Of Ubiquitin-specific Protease Activity Cognition Negative Regulation Of Signal Transduction Acetylcholine Receptor Activator Activity Developmental Growth Response To Interleukin-1 Plasma Membrane Bounded Cell Projection Organization Regulation Of MiRNA Transcription Negative Regulation Of Signaling Cellular Localization Lipoprotein Particle Regulation Of Programmed Cell Death Positive Regulation Of Protein Import Negative Regulation Of Cell Communication Nervous System Process ERBB Signaling Pathway Phospholipase D Activator Activity Negative Regulation Of Blood Vessel Remodeling Negative Regulation Of Neutrophil Degranulation Positive Regulation Of Brain-derived Neurotrophic Factor Receptor Signaling Pathway Shc-EGFR Complex Regulation Of MiRNA Metabolic Process Negative Regulation Of Programmed Cell Death PTB Domain Binding Axon Collateral Sprouting In Absence Of Injury Regulation Of Protein Import