FGD5 and JMJD6

Number of citations of the paper that reports this interaction (PubMedID 23455924)
0

Data Source:
BioGRID (two hybrid)

		FGD5	JMJD6
Description		FYVE, RhoGEF and PH domain containing 5	jumonji domain containing 6, arginine demethylase and lysine hydroxylase
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GO Annotations	Cellular Component	Ruffle Cytoplasm Endosome Early Endosome Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Membrane Lamellipodium Ruffle Membrane Cell Projection	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Ribonucleoprotein Complex
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Zinc Ion Binding Small GTPase Binding Metal Ion Binding	RNA Binding Single-stranded RNA Binding Iron Ion Binding Protein Binding Oxidoreductase Activity Histone Demethylase Activity Histone H3R2 Demethylase Activity Histone H4R3 Demethylase Activity Oxidative RNA Demethylase Activity Signaling Receptor Activity Identical Protein Binding Metal Ion Binding Dioxygenase Activity Peptidyl-lysine 5-dioxygenase Activity P-TEFb Complex Binding Protein Demethylase Activity Transcription Regulator Activator Activity
	Biological Process	Cytoskeleton Organization Regulation Of Cell Shape Actin Cytoskeleton Organization Regulation Of GTPase Activity Filopodium Assembly Regulation Of Small GTPase Mediated Signal Transduction	Blood Vessel Development Kidney Development Sprouting Angiogenesis Chromatin Organization Chromatin Remodeling MRNA Processing Phagocytosis Cell Surface Receptor Signaling Pathway Heart Development RNA Splicing Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Cell Differentiation Lung Development Negative Regulation Of Protein Homooligomerization T Cell Differentiation In Thymus Oxidative RNA Demethylation Macrophage Activation Apoptotic Cell Clearance Recognition Of Apoptotic Cell Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of MRNA Splicing, Via Spliceosome Erythrocyte Development Protein Homooligomerization Retina Development In Camera-type Eye Membraneless Organelle Assembly
Pathways		RAC1 GTPase cycle	HDMs demethylate histones Protein hydroxylation
Drugs
Diseases
GWAS		Alcohol dependence ( 24166409) Coronary artery disease ( 33020668 28714974 29212778 32469254) Diastolic blood pressure ( 27618452 27841878 28135244 29403010 30487518) Haemorrhoidal disease ( 33888516) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hypertension ( 30487518 31217584) Mean arterial pressure ( 30487518 29403010) Myocardial infarction ( 33532862) Offspring birth weight ( 31043758) Pulse pressure ( 30578418) Red blood cell count ( 32888494) Systolic blood pressure ( 29403010 30487518 30578418 27841878 27618452)	Neutrophil count ( 32888494) Retinal arteriolar caliber ( 23776548)
Interacting Genes		4 interacting genes: CFTR JMJD6 RAC1 SUV39H1	30 interacting genes: AEBP2 ANKEF1 CCNL1 CENPL CXCL14 DIP2A FGD5 FRMD6 GNA14 H2BC11 H3C1 H4C1 HMGXB4 IRF3 LARP7 LIAT1 NAA50 NFIX NHP2 OGT PRPF38A PSMC1 RNF5 RSPO2 SLFN12 SLU7 STAC3 TAF1A U2AF1 ZNF451
Entrez ID		152273	23210
HPRD ID		13322	05371
Ensembl ID		ENSG00000154783	ENSG00000070495
Uniprot IDs		A0A2X0SFF2 B7ZM68 Q6ZNL6	B2WTI3 B2WTI4 Q6NYC1
PDB IDs		3MPX	3K2O 3LD8 3LDB 6BNH 6GDY 6MEV
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Positive Regulation Of Insulin Secretion Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Recycling Endosome Membrane Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Multicellular Organismal-level Homeostasis Sec61 Translocon Complex Binding Histone H4R3 Demethylase Activity Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Peptidyl-lysine 5-dioxygenase Activity Histone H3R2 Demethylase Activity Oxidative RNA Demethylation Positive Regulation Of Anion Channel Activity Positive Regulation Of Protein Secretion Positive Regulation Of Hormone Secretion Positive Regulation Of Ovarian Follicle Development Negative Regulation Of Interleukin-23 Production Regulation Of ERK5 Cascade Angiotensin-activated Signaling Pathway Involved In Heart Process Embryonic Olfactory Bulb Interneuron Precursor Migration Cerebral Cortex GABAergic Interneuron Development Regulation Of Insulin Secretion Regulation Of Peptide Hormone Secretion Early Endosome Membrane Cellular Developmental Process Positive Regulation Of Enamel Mineralization Positive Regulation Of Monoatomic Anion Transport Rho GDP-dissociation Inhibitor Binding Regulation Of Cell Adhesion Involved In Heart Morphogenesis Histone H3K9 Trimethyltransferase Activity ENoSc Complex Negative Regulation Of Protein Homooligomerization Oxidative RNA Demethylase Activity Protein Demethylase Activity P-TEFb Complex Binding Negative Regulation Of Protein Oligomerization Transepithelial Water Transport Regulation Of Ovarian Follicle Development Erythrocyte Enucleation RDNA Heterochromatin Positive Regulation Of Protein Transport Regulation Of Hormone Secretion Regulation Of Protein Secretion Positive Regulation Of Tooth Mineralization Auditory Receptor Cell Morphogenesis Engulfment Of Apoptotic Cell Tangential Migration From The Subventricular Zone To The Olfactory Bulb	Pre-mRNA 3'-splice Site Binding SnRNA Modification Nucleoplasm Nucleus
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