FGD5

Description		FYVE, RhoGEF and PH domain containing 5
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GO Annotations	Cellular Component	Ruffle Cytoplasm Endosome Early Endosome Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Membrane Lamellipodium Ruffle Membrane Cell Projection
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Zinc Ion Binding Small GTPase Binding Metal Ion Binding
	Biological Process	Cytoskeleton Organization Regulation Of Cell Shape Actin Cytoskeleton Organization Regulation Of GTPase Activity Filopodium Assembly Regulation Of Small GTPase Mediated Signal Transduction
Pathways		RAC1 GTPase cycle
Drugs
Diseases
GWAS		Alcohol dependence ( 24166409) Coronary artery disease ( 33020668 28714974 29212778 32469254) Diastolic blood pressure ( 27618452 27841878 28135244 29403010 30487518) Haemorrhoidal disease ( 33888516) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hypertension ( 30487518 31217584) Mean arterial pressure ( 30487518 29403010) Myocardial infarction ( 33532862) Offspring birth weight ( 31043758) Pulse pressure ( 30578418) Red blood cell count ( 32888494) Systolic blood pressure ( 29403010 30487518 30578418 27841878 27618452)
Interacting Genes		4 interacting genes: CFTR JMJD6 RAC1 SUV39H1
Entrez ID		152273
HPRD ID		13322
Ensembl ID		ENSG00000154783
Uniprot IDs		A0A2X0SFF2 B7ZM68 Q6ZNL6
PDB IDs		3MPX
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Positive Regulation Of Insulin Secretion Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Recycling Endosome Membrane Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Multicellular Organismal-level Homeostasis Sec61 Translocon Complex Binding Histone H4R3 Demethylase Activity Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Peptidyl-lysine 5-dioxygenase Activity Histone H3R2 Demethylase Activity Oxidative RNA Demethylation Positive Regulation Of Anion Channel Activity Positive Regulation Of Protein Secretion Positive Regulation Of Hormone Secretion Positive Regulation Of Ovarian Follicle Development Negative Regulation Of Interleukin-23 Production Regulation Of ERK5 Cascade Angiotensin-activated Signaling Pathway Involved In Heart Process Embryonic Olfactory Bulb Interneuron Precursor Migration Cerebral Cortex GABAergic Interneuron Development Regulation Of Insulin Secretion Regulation Of Peptide Hormone Secretion Early Endosome Membrane Cellular Developmental Process Positive Regulation Of Enamel Mineralization Positive Regulation Of Monoatomic Anion Transport Rho GDP-dissociation Inhibitor Binding Regulation Of Cell Adhesion Involved In Heart Morphogenesis Histone H3K9 Trimethyltransferase Activity ENoSc Complex Negative Regulation Of Protein Homooligomerization Oxidative RNA Demethylase Activity Protein Demethylase Activity P-TEFb Complex Binding Negative Regulation Of Protein Oligomerization Transepithelial Water Transport Regulation Of Ovarian Follicle Development Erythrocyte Enucleation RDNA Heterochromatin Positive Regulation Of Protein Transport Regulation Of Hormone Secretion Regulation Of Protein Secretion Positive Regulation Of Tooth Mineralization Auditory Receptor Cell Morphogenesis Engulfment Of Apoptotic Cell Tangential Migration From The Subventricular Zone To The Olfactory Bulb
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