TTC14 and IK

Number of citations: 0 (PubMedID 22365833)
Data Source: BioGRID (two hybrid)

		TTC14	IK
Name		tetratricopeptide repeat domain 14	IK cytokine
Structure		No pdb structure
GO Annotations	Cellular Component	None	Nuclear Chromosome Spindle Pole Nucleus Nucleoplasm Spliceosomal Complex Chromosome Cytoplasm Cytoskeleton Nuclear Speck U2-type Precatalytic Spliceosome Mitotic Spindle Pole
	Molecular Function	Nucleic Acid Binding	Protein Binding Identical Protein Binding
	Biological Process	None	Mitotic Cell Cycle MRNA Splicing, Via Spliceosome MRNA Processing Mitotic Spindle Assembly Checkpoint Signaling RNA Splicing Protein Localization To Kinetochore
Pathways		None	mRNA Splicing - Major Pathway
GWAS		Glucose homeostasis traits ( 25524916 )	Monocyte count ( 32888494 ) Schizophrenia ( 29483656 ) Serum immune biomarker levels ( 32066700 )
Novel Interactors		1 novel interactors: CCDC39	None recorded
Interacting Genes		11 interacting genes: CCDC85B CHERP ESS2 FRA10AC1 IK NKAP RBM39 SF3B2 SNIP1 SNW1 SRRM2	28 interacting genes: APP CEBPA CEP70 CHD3 CTNNBL1 DDX6 EGLN3 FANCC FRA10AC1 FXR1 GRB2 KAT5 KDM1A MBD3 MFAP1 NUP62 OGT PFN2 QARS1 RACK1 RBM10 SUPT5H THOC1 TOE1 TRIM55 TRIM63 TTC14 ZCCHC10
Entrez ID		151613	3550
HPRD ID		15579	02771
Ensembl ID		ENSG00000163728	ENSG00000113141
Uniprot IDs		Q96N46	Q13123 Q95HA6 Q9UK43
PDB IDs		Not available	5O9Z 6Q8I 8QO9 8QZS
GO Terms Enriched among Interactors		RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions MRNA Processing RNA Processing MRNA Metabolic Process Spliceosomal Complex U2-type Precatalytic Spliceosome Catalytic Step 2 Spliceosome RNA Metabolic Process Nuclear Speck Nucleic Acid Metabolic Process RNA Binding Nucleobase-containing Compound Metabolic Process U2-type Prespliceosome Assembly U2 SnRNP U2-type Catalytic Step 2 Spliceosome Spliceosomal Complex Assembly Nucleus Nucleoplasm	Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus PTB Domain Binding Negative Regulation Of RNA Metabolic Process Chromatin Binding Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Nucleoplasm Negative Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Apoptotic Process Regulation Of Glycolytic Process Programmed Cell Death Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Cell Death Regulation Of Programmed Cell Death RNA Binding Membraneless Organelle Assembly Cellular Response To Glucose Stimulus Regulation Of Carbohydrate Catabolic Process Negative Regulation Of Long-term Synaptic Potentiation Protein-containing Complex Nucleic Acid Metabolic Process Positive Regulation Of Proteolysis Regulation Of ATP Metabolic Process Positive Regulation Of Catabolic Process Negative Regulation Of Gene Expression Regulation Of Purine Nucleotide Metabolic Process Regulation Of Apoptotic Process Carbohydrate Homeostasis Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Glucose Homeostasis Regulation Of Stem Cell Differentiation NuRD Complex Negative Regulation Of Translation Nucleic Acid Binding MRNA Splicing, Via Spliceosome RNA Splicing Cellular Response To Carbohydrate Stimulus Positive Regulation Of RNA Metabolic Process Post-transcriptional Regulation Of Gene Expression RNA Splicing, Via Transesterification Reactions Positive Regulation Of Metabolic Process Translation Regulator Activity Intracellular Glucose Homeostasis