KLHL23 and ANXA1

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		KLHL23	ANXA1
Gene Name		kelch-like family member 23	annexin A1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component		Cornified Envelope Extracellular Region Extracellular Space Nucleus Cytoplasm Endosome Plasma Membrane Focal Adhesion Cilium Cell Surface Basolateral Plasma Membrane Mitochondrial Membrane Vesicle Sarcolemma Mast Cell Granule Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Protein Binding	Single-stranded DNA Binding Single-stranded RNA Binding Helicase Activity Receptor Binding Structural Molecule Activity Calcium Ion Binding Protein Binding Phospholipid Binding Calcium-dependent Phospholipid Binding Phospholipase A2 Inhibitor Activity Protein Binding, Bridging Double-stranded DNA-dependent ATPase Activity Annealing Helicase Activity Protein Homodimerization Activity Calcium-dependent Protein Binding
	Biological Process		DNA Strand Renaturation Neutrophil Homeostasis Movement Of Cell Or Subcellular Component Inflammatory Response Signal Transduction Cell Surface Receptor Signaling Pathway Response To X-ray Peptide Cross-linking Insulin Secretion Keratinocyte Differentiation Prostate Gland Development Endocrine Pancreas Development Positive Regulation Of Vesicle Fusion Positive Regulation Of Prostaglandin Biosynthetic Process Response To Estradiol DNA Duplex Unwinding Positive Regulation Of Neutrophil Apoptotic Process DNA Rewinding Gliogenesis Regulation Of Cell Proliferation Response To Drug Negative Regulation Of Apoptotic Process Response To Peptide Hormone Alpha-beta T Cell Differentiation Arachidonic Acid Secretion Cellular Response To Hydrogen Peroxide Hepatocyte Differentiation Prolactin Secretion Response To Interleukin-1 Cellular Response To Glucocorticoid Stimulus Neutrophil Clearance Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Phospholipase A2 Activity Negative Regulation Of Interleukin-8 Secretion
Pathways			G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Class A/1 (Rhodopsin-like receptors) GPCR ligand binding Metabolic disorders of biological oxidation enzymes Formyl peptide receptors bind formyl peptides and many other ligands G alpha (q) signalling events GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK G alpha (i) signalling events
Drugs			Amcinonide Hydrocortisone Dexamethasone
Diseases
GWAS		Obesity-related traits ( 23251661)	Schizophrenia, bipolar disorder and depression (combined) ( 20713499)
Protein-Protein Interactions		5 interactors: ANXA1 ANXA7 BNIP3L CDKN1A TK1	31 interactors: APBB1 C14orf1 C1orf123 CCT7 COPS6 CSAD DYSF EGFR FAF1 FPR1 GAPDH HMGA1 KLHL23 KMT2B KRT8 LRIF1 MEIS2 OTUB1 PRKCI RPA1 S100A11 SRC TGM2 TRPM7 UBE2D1 UBE2I UBE3A UCHL5 UNC119 XRCC6 YWHAQ
Entrez ID		151230	301
HPRD ID		11320	01060
Ensembl ID		ENSG00000213160	ENSG00000135046
Uniprot IDs		Q8NBE8	P04083 Q5TZZ9
PDB IDs			1AIN 1BO9 1QLS
Enriched GO Terms of Interacting Partners?		Response To Glucocorticoid Response To Corticosteroid Response To Organic Cyclic Compound Response To X-ray Response To Inorganic Substance Response To Steroid Hormone Epithelial Cell Differentiation Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Neutrophil Clearance Fetal Process Involved In Parturition Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Digestive Tract Development Response To Ionizing Radiation Digestive System Development DNA Rewinding Positive Regulation Of Neutrophil Apoptotic Process Skeletal Muscle Cell Proliferation Liver Development Response To Lipid Negative Regulation Of Apoptotic Process Response To Toxic Substance Negative Regulation Of Programmed Cell Death Response To Organic Substance Negative Regulation Of Phospholipase A2 Activity Mitochondrial Protein Catabolic Process Response To Hormone Negative Regulation Of Cell Death Negative Regulation Of Interleukin-8 Secretion Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Epithelium Development Response To Abiotic Stimulus Regulation Of Cell Cycle Phase Transition Intestinal Epithelial Cell Maturation Prolactin Secretion Response To Cortisol Positive Regulation Of Prostaglandin Biosynthetic Process Thymidine Metabolic Process Negative Regulation Of Phospholipase Activity Positive Regulation Of Cell Cycle Cellular Response To UV-B Deoxyribonucleoside Monophosphate Biosynthetic Process Defense Response Response To Metal Ion Pyrimidine Nucleoside Salvage Pyrimidine-containing Compound Salvage Response To Stress Apoptotic Signaling Pathway	Negative Regulation Of Biosynthetic Process Viral Process Response To Abiotic Stimulus Regulation Of Protein Metabolic Process Cellular Protein Modification Process Regulation Of Cellular Protein Metabolic Process Cellular Protein Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Regulation Of Caveolin-mediated Endocytosis Establishment Of Integrated Proviral Latency Positive Regulation Of Transferase Activity Establishment Of Viral Latency Cellular Macromolecule Catabolic Process Regulation Of Metabolic Process Regulation Of DNA Repair Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death DNA Repair Response To Growth Factor Negative Regulation Of Protein Metabolic Process Positive Regulation Of Cell Death Regulation Of Protein Catabolic Process Positive Regulation Of Signal Transduction Peptidyl-amino Acid Modification Organ Development Magnesium Ion Homeostasis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Programmed Cell Death Organelle Organization Catabolic Process Cell Death Death Positive Regulation Of Gene Expression, Epigenetic Regulation Of Transcription, DNA-templated Response To Stimulus Regulation Of Gene Expression Peptidyl-lysine Modification Protein Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Brain Development Reproductive Structure Development Ubiquitin-dependent Protein Catabolic Process Reproductive System Development Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Tagcloud ?			aldh1a1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1
Tagcloud (Difference) ?			aldh1a1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1
Tagcloud (Intersection) ?