METTL21A and HSPA8

Number of citations of the paper that reports this interaction (PMID 23349634)
10

Data Source:
BioGRID (enzymatic study)

		METTL21A	HSPA8
Gene Name		methyltransferase like 21A	heat shock 70kDa protein 8
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm	Ubiquitin Ligase Complex Prp19 Complex Extracellular Space Intracellular Nucleus Nucleoplasm Spliceosomal Complex Nucleolus Cytosol Plasma Membrane Focal Adhesion Membrane Ribonucleoprotein Complex Melanosome Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Protein Binding Protein-lysine N-methyltransferase Activity Hsp70 Protein Binding ATPase Binding	G-protein Coupled Receptor Binding Protein Binding ATP Binding ATPase Activity Enzyme Binding MHC Class II Protein Complex Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding ATPase Activity, Coupled Poly(A) RNA Binding Unfolded Protein Binding
	Biological Process	Protein Methylation Peptidyl-lysine Methylation Regulation Of ATPase Activity	MRNA Splicing, Via Spliceosome Transcription, DNA-templated Protein Folding Post-Golgi Vesicle-mediated Transport Response To Unfolded Protein Synaptic Transmission Neurotransmitter Secretion Axon Guidance RNA Splicing Gene Expression Viral Process Cellular Response To Heat Protein Refolding Negative Regulation Of Transcription, DNA-templated Positive Regulation Of MRNA Splicing, Via Spliceosome Chaperone Mediated Protein Folding Requiring Cofactor Regulation Of Cell Cycle Membrane Organization Clathrin Coat Disassembly Regulation Of Cellular Response To Heat Negative Regulation Of Fibril Organization
Pathways			Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing Regulation of mRNA stability by proteins that bind AU-rich elements Axon guidance Golgi Associated Vesicle Biogenesis Attenuation phase mRNA Splicing - Major Pathway L1CAM interactions Regulation of HSF1-mediated heat shock response Cellular response to heat stress AUF1 (hnRNP D0) destabilizes mRNA GABA synthesis, release, reuptake and degradation Clathrin derived vesicle budding Lysosome Vesicle Biogenesis HSF1-dependent transactivation Neurotransmitter Release Cycle CHL1 interactions trans-Golgi Network Vesicle Budding Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Opioid sensitivity ( 23183491)
Protein-Protein Interactions		5 interactors: ATRIP HSPA1A HSPA5 HSPA8 LNX1	83 interactors: ABI1 AIPL1 ALDOB APOB BAG1 BAG2 BAG3 BAG4 BAG6 BRCA1 CAPZA1 CAPZB CCAR2 CCT3 CD40 CDKN2A CITED1 CLTA COL7A1 CXCR4 CYCS DNAJA1 DNAJA3 DNAJB1 DNAJC7 DPP3 DYNLL1 EGFR ERH ESR1 FANCC FBP1 GAK GCH1 GOT2 HDAC10 HDAC3 HGS HLTF HSF1 HSP90AA1 HSPA1A HSPBP1 HSPH1 HTT IL32 JAK2 JUN LALBA MAPK8 MAPT METTL21A NMI NOA1 PHC1 PPID RAF1 RB1 REL RGS2 SGTA SNCA SP1 SRRT ST13 STIP1 STMN1 STUB1 SUMO4 TADA3 TCERG1 TCP1 TGM2 TM4SF1 TNFRSF1A TRIM38 TSSK6 TTC1 UBC UCHL1 VHL YWHAG YWHAQ
Entrez ID		151194	3312
HPRD ID		14090	07205
Ensembl ID		ENSG00000144401	ENSG00000109971
Uniprot IDs		H7BXH9 Q8WXB1	P11142 Q53HF2
PDB IDs		4LEC	3AGY 3AGZ 3ESK 3FZF 3FZH 3FZK 3FZL 3FZM 3LDQ 3M3Z 4HWI
Enriched GO Terms of Interacting Partners?		Response To Unfolded Protein Protein Refolding Regulation Of Cellular Response To Heat Cellular Response To Heat Cellular Response To Stress Negative Regulation Of Fibril Organization Regulation Of Protein Folding In Endoplasmic Reticulum Response To Heat Cerebellum Structural Organization Cellular Heat Acclimation Cellular Macromolecule Catabolic Process Regulation Of Fibril Organization Response To Temperature Stimulus Regulation Of Protein Ubiquitination Clathrin Coat Disassembly Protein Folding Response To Stress Negative Regulation Of Inclusion Body Assembly ER Overload Response Maintenance Of Protein Localization In Endoplasmic Reticulum Catabolic Process Regulation Of Inclusion Body Assembly Response To External Stimulus Chaperone Mediated Protein Folding Requiring Cofactor Cellular Response To Antibiotic Positive Regulation Of MRNA Splicing, Via Spliceosome Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Erythrocyte Differentiation Anatomical Structure Arrangement Modification-dependent Protein Catabolic Process Secretion By Cell Cellular Protein Metabolic Process MRNA Metabolic Process Cellular Response To Toxic Substance Viral Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Response To Glucose Starvation Cellular Protein Catabolic Process Positive Regulation Of RNA Splicing Protein Catabolic Process Secretion Cerebellar Purkinje Cell Layer Development Regulation Of Erythrocyte Differentiation Substantia Nigra Development ER-associated Ubiquitin-dependent Protein Catabolic Process Toxin Transport Viral Entry Into Host Cell Cellular Response To Interleukin-4 Entry Into Host Cell Response To Biotic Stimulus	Regulation Of Cell Death Protein Folding Regulation Of Apoptotic Process Apoptotic Process Programmed Cell Death Cell Death Death Protein Refolding Response To Stress Regulation Of Signal Transduction Response To Stimulus Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cell Death Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Response To Organic Substance Cellular Response To Stimulus Regulation Of Signaling Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Metabolic Process Response To Abiotic Stimulus Protein Metabolic Process Regulation Of Protein Stability Regulation Of Protein Phosphorylation Negative Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Catalytic Activity Negative Regulation Of Protein Metabolic Process Apoptotic Signaling Pathway Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorylation Negative Regulation Of Signaling Defense Response Chaperone Cofactor-dependent Protein Refolding Regulation Of Intracellular Signal Transduction Regulation Of Transcription From RNA Polymerase II Promoter Signal Transduction Positive Regulation Of Signal Transduction Cell Communication Cellular Response To Organic Substance Protein Complex Assembly Negative Regulation Of Phosphorylation Positive Regulation Of Cellular Metabolic Process
Tagcloud ?			alteration cadherin cd133 cognate ectopically electrophoresis filament glioblastoma glioblastomas gliomas hairpin hsc71 interfere invasion modulating nanog nestin oct overexpress progenitor restored shrna sphere stemness suppresses transfected transfection tumorigenic vi
Tagcloud (Difference) ?			alteration cadherin cd133 cognate ectopically electrophoresis filament glioblastoma glioblastomas gliomas hairpin hsc71 interfere invasion modulating nanog nestin oct overexpress progenitor restored shrna sphere stemness suppresses transfected transfection tumorigenic vi
Tagcloud (Intersection) ?