FAM117B and DYNLL2

Number of citations of the paper that reports this interaction (PubMedID 35271311)
106

Data Source:
BioGRID (two hybrid, affinity chromatography technology, affinity chromatography technology)

		FAM117B	DYNLL2
Description		family with sequence similarity 117 member B	dynein light chain LC8-type 2
Image		No pdb structure
GO Annotations	Cellular Component		Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Cytoplasmic Dynein Complex Microtubule Microtubule Associated Complex Plasma Membrane Cilium Postsynaptic Density Microtubule Cytoskeleton Membrane Dynein Complex Myosin V Complex Ciliary Tip 9+0 Non-motile Cilium Postsynapse Glutamatergic Synapse
	Molecular Function	Protein Binding	Protein Binding Identical Protein Binding Protein-containing Complex Binding Dynein Intermediate Chain Binding Scaffold Protein Binding
	Biological Process		Microtubule-based Process
Pathways			Activation of BMF and translocation to mitochondria Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Macroautophagy MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Intraflagellar transport RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cholesterol, total ( 25961943 24097068) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Feeling fed-up ( 29500382) HDL cholesterol levels ( 32203549) High light scatter reticulocyte count ( 32888494) LDL cholesterol ( 25961943) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Sarcoidosis ( 26051272) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Total cholesterol levels ( 30275531 28334899)	Blood protein levels ( 30072576)
Interacting Genes		5 interacting genes: AGR2 BANP DYNLL2 KEAP1 STAT3	30 interacting genes: BMF C14orf119 DLGAP1 DNAL4 DPPA3 DYNC1I1 EWSR1 FAM117B GABARAPL2 GPHN GPRIN2 HDAC6 HOMER3 IHO1 MEOX2 MORN3 MYO5A OTUD6A PAK1 PKIA PKIG RASGRP3 REDIC1 SKAP1 SMCP SPAG8 THAP10 TPPP XIAP ZAR1
Entrez ID		150864	140735
HPRD ID		12445	06489
Ensembl ID		ENSG00000138439	ENSG00000264364
Uniprot IDs		Q6P1L5	Q96FJ2
PDB IDs			2XQQ 3P8M 4D07 7CNU
Enriched GO Terms of Interacting Partners?			Microtubule Binding
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