SERPINB13 and CTSK

Number of citations of the paper that reports this interaction (PubMedID 12504904)
0

Data Source:
HPRD (in vitro)

		SERPINB13	CTSK
Description		serpin family B member 13	cathepsin K
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleoplasm Nucleolus Cytoplasm Cytosol Nuclear Speck Lysosomal Lumen Extracellular Exosome	Extracellular Region Extracellular Space Nucleoplasm Lysosome Plasma Membrane External Side Of Plasma Membrane Membrane Apical Plasma Membrane Endolysosome Lumen Lysosomal Lumen
	Molecular Function	Protease Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity	Fibronectin Binding Cysteine-type Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Collagen Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Proteoglycan Binding
	Biological Process	Response To UV Negative Regulation Of Endopeptidase Activity Regulation Of Proteolysis Negative Regulation Of Keratinocyte Apoptotic Process	Mitophagy Proteolysis Thyroid Hormone Generation Extracellular Matrix Disassembly Collagen Catabolic Process Bone Resorption Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Cartilage Development
Pathways		RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	Collagen degradation Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Trafficking and processing of endosomal TLR MHC class II antigen presentation RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
Drugs			[1-(4-Fluorobenzyl)Cyclobutyl]Methyl (1s)-1-[Oxo(1h-Pyrazol-5-Ylamino)Acetyl]Pentylcarbamate Cyanamide 3-amino-5-phenylpentane N2-[(Benzyloxy)carbonyl]-N-[(3R)-1-{N-[(benzyloxy)carbonyl]-L-leucyl}-4-oxo-3-pyrrolidinyl]-L-leucinamide N2-[(benzyloxy)carbonyl]-n1-[(3S)-1-cyanopyrrolidin-3-yl]-l-leucinamide N-[(2S)-4-Methyl-1-oxo-1-{[(4S)-3-oxo-1-(2-pyridinylsulfonyl)-4-azepanyl]amino}-2-pentanyl]-1-benzofuran-2-carboxamide Dibenzyl (carbonylbis{2,1-hydrazinediyl[(2S)-4-methyl-1-oxo-1,2-pentanediyl]})biscarbamate N2-({[(4-Bromophenyl)Methyl]Oxy}Carbonyl)-N1-[(1s)-1-Formylpentyl]-L-Leucinamide (2R)-2-(3-Biphenylyl)-N-{(2R)-2-hydroxy-3-[(2-pyridinylsulfonyl)amino]propyl}-4-methylpentanamide Tert-Butyl(1s)-1-Cyclohexyl-2-Oxoethylcarbamate MIV-701 Relacatib Odanacatib 1-{7-cyclohexyl-6-[4-(4-methylpiperazin-1-yl)benzyl]-7H-pyrrolo[2,3-d]pyrimidin-2-yl}methanamine (2R)-3-Methyl-1-phenyl-2-butanyl [(2S)-1-oxo-2-hexanyl]carbamate 1-(PHENYLMETHYL)CYCLOPENTYL[(1S)-1-FORMYLPENTYL]CARBAMATE 6-(cyclohexylamino)-9-[2-(4-methylpiperazin-1-yl)-ethyl]-9H-purine-2-carbonitrile 9-CYCLOPENTYL-6-[2-(3-IMIDAZOL-1-YL-PROPOXY)-PHENYLAMINO]-9H-PURINE-2-CARBONITRILE N-(2-AMINOETHYL)-N~2~-{(1S)-1-[4'-(AMINOSULFONYL)BIPHENYL-4-YL]-2,2,2-TRIFLUOROETHYL}-L-LEUCINAMIDE (1R,2R)-N-(2-Aminoethyl)-2-{[(4-methoxyphenyl)sulfonyl]methyl}cyclohexanecarboxamide TERT-BUTYL 2-CYANO-2-METHYLHYDRAZINECARBOXYLATE Balicatib MIV-711
Diseases			Pycnodysostosis
GWAS		Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Sum eosinophil basophil counts ( 27863252)	Aspartate aminotransferase levels ( 33547301) Body mass index ( 26426971) Congenital left-sided heart lesions ( 26965164) Melanoma ( 21983785) Rhegmatogenous retinal detachment ( 23585552)
Interacting Genes		9 interacting genes: CTSB CTSG CTSK CTSL DLG2 ELANE PLG PRSS1 PRTN3	6 interacting genes: FGFR3 KNG1 LIG4 SERPINB13 SERPINB3 SPARC
Entrez ID		5275	1513
HPRD ID		05118	03064
Ensembl ID		ENSG00000197641	ENSG00000143387
Uniprot IDs		A0A0A0MQW3 B7Z447 Q9UIV8	P43235
PDB IDs			1ATK 1AU0 1AU2 1AU3 1AU4 1AYU 1AYV 1AYW 1BGO 1BY8 1MEM 1NL6 1NLJ 1Q6K 1SNK 1TU6 1U9V 1U9W 1U9X 1VSN 1YK7 1YK8 1YT7 2ATO 2AUX 2AUZ 2BDL 2R6N 3C9E 3H7D 3KW9 3KWB 3KWZ 3KX1 3O0U 3O1G 3OVZ 4DMX 4DMY 4N79 4N8W 4X6H 4X6I 4X6J 4YV8 4YVA 5J94 5JA7 5JH3 5TDI 5TUN 5Z5O 6ASH 6HGY 6PXF 6QBS 6QL8 6QLM 6QLW 6QLX 6QM0 7NXL 7NXM 7PCK 7QBL 7QBM 7QBN 7QBO 8C3D
Enriched GO Terms of Interacting Partners?		Peptidase Activity Extracellular Matrix Disassembly Serine-type Endopeptidase Activity Extracellular Matrix Endolysosome Lumen Serine-type Peptidase Activity Collagen Catabolic Process Proteolysis Collagen Metabolic Process Extracellular Space Proteoglycan Binding Hydrolase Activity Extracellular Matrix Organization Extracellular Structure Organization Extracellular Region Biological Process Involved In Interaction With Symbiont Hormone Metabolic Process Leukocyte Migration Cysteine-type Endopeptidase Activity Collagen Binding Protein Metabolic Process Endopeptidase Activity Azurophil Granule Lumen Neutrophil-mediated Killing Of Bacterium Cellular Response To Thyroid Hormone Stimulus Thyroid Hormone Generation Cysteine-type Peptidase Activity Thyroid Hormone Metabolic Process Response To Thyroid Hormone Neutrophil Mediated Immunity Lysosome Protein Processing Regulation Of Hormone Levels Fibronectin Binding Killing By Host Of Symbiont Cells Extracellular Exosome Peptide Hormone Processing Signaling Receptor Ligand Precursor Processing Macromolecule Metabolic Process Defense Response To Fungus Response To Fungus Protein Maturation Biofilm Matrix Disassembly Serpin Family Protein Binding Fusion Of Virus Membrane With Host Endosome Membrane Biosynthetic Process Of Antibacterial Peptides Active Against Gram-negative Bacteria External Side Of Plasma Membrane Regulation Of Biological Quality Leukocyte Mediated Cytotoxicity Apical Plasma Membrane	Cysteine-type Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity Negative Regulation Of Endopeptidase Activity Negative Regulation Of Proteolysis Negative Regulation Of Peptidase Activity Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Endopeptidase Inhibitor Activity Platelet Alpha Granule Lumen Regulation Of Proteolysis Establishment Of Integrated Proviral Latency Negative Regulation Of Keratinocyte Apoptotic Process Serine-type Endopeptidase Inhibitor Activity Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway Establishment Of Viral Latency Protease Binding Positive Regulation Of Hydrolase Activity Positive Regulation Of Phospholipase Activity Bone Maturation Regulation Of Catalytic Activity Extracellular Space Negative Regulation Of Protein Metabolic Process DNA Ligase (ATP) Activity DNA Ligase IV Complex Pro-B Cell Differentiation T Cell Receptor V(D)J Recombination DNA Ligase Activity DN2 Thymocyte Differentiation Regulation Of Protein Metabolic Process Negative Regulation Of Catalytic Activity Fibroblast Growth Factor Receptor Activity Regulation Of Cell Population Proliferation Nucleotide-excision Repair, DNA Gap Filling Positive Regulation Of Lipase Activity DNA-dependent Protein Kinase-DNA Ligase 4 Complex Immunoglobulin V(D)J Recombination Nonhomologous End Joining Complex Regulation Of Keratinocyte Apoptotic Process Autocrine Signaling Negative Regulation Of JUN Kinase Activity Paracrine Signaling Positive Regulation Of Endopeptidase Activity Semicircular Canal Morphogenesis BBSome Endochondral Bone Growth Positive Regulation Of Cell Population Proliferation Double-strand Break Repair Via Classical Nonhomologous End Joining Single Strand Break Repair Positive Regulation Of Peptidase Activity Lymphoid Progenitor Cell Differentiation
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