SERPINB13 and CTSK

Number of citations of the paper that reports this interaction (PMID 12504904)
5

Data Source:
HPRD (in vitro)

		SERPINB13	CTSK
Gene Name		serpin peptidase inhibitor, clade B (ovalbumin), member 13	cathepsin K
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Endolysosome Lumen
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity	Fibronectin Binding Cysteine-type Endopeptidase Activity Collagen Binding Cysteine-type Peptidase Activity Proteoglycan Binding
	Biological Process	Response To UV Negative Regulation Of Endopeptidase Activity Regulation Of Proteolysis	Intramembranous Ossification Toll-like Receptor Signaling Pathway Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Innate Immune Response Bone Resorption Proteolysis Involved In Cellular Protein Catabolic Process
Pathways			Toll-Like Receptors Cascades Trafficking and processing of endosomal TLR Collagen degradation Activation of Matrix Metalloproteinases MHC class II antigen presentation Degradation of the extracellular matrix Adaptive Immune System Innate Immune System
Drugs
Diseases
GWAS			Melanoma ( 21983785) Rhegmatogenous retinal detachment ( 23585552)
Protein-Protein Interactions		8 interactors: CTSB CTSG CTSK CTSL ELANE PLG PRSS1 PRTN3	6 interactors: FGFR3 KNG1 LIG4 SERPINB13 SERPINB3 SPARC
Entrez ID		5275	1513
HPRD ID		05118	03064
Ensembl ID		ENSG00000197641	ENSG00000143387
Uniprot IDs		Q9UIV8	P43235
PDB IDs			1ATK 1AU0 1AU2 1AU3 1AU4 1AYU 1AYV 1AYW 1BGO 1BY8 1MEM 1NL6 1NLJ 1Q6K 1SNK 1TU6 1U9V 1U9W 1U9X 1VSN 1YK7 1YK8 1YT7 2ATO 2AUX 2AUZ 2BDL 2R6N 3C9E 3H7D 3KW9 3KWB 3KWZ 3KX1 3O0U 3O1G 3OVZ 4DMX 4DMY 7PCK
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Proteolysis Immune System Process Protein Catabolic Process Positive Regulation Of Immune Response Killing By Host Of Symbiont Cells Regulation Of Immune Response Positive Regulation Of Immune System Process Catabolic Process Cellular Response To Thyroid Hormone Stimulus Toll-like Receptor Signaling Pathway Protein Metabolic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Response To Stress Response To Thyroid Hormone Activation Of Innate Immune Response Proteolysis Involved In Cellular Protein Catabolic Process Neutrophil Mediated Immunity Cellular Protein Catabolic Process Immune Response Regulation Of Immune System Process Positive Regulation Of Innate Immune Response Defense Response Killing Of Cells Of Other Organism Negative Regulation Of Growth Of Symbiont In Host Defense Response To Fungus Interaction With Symbiont Leukocyte Mediated Cytotoxicity Regulation Of Innate Immune Response Response To Fungus Cellular Macromolecule Catabolic Process Immune Response-regulating Signaling Pathway Tissue Remodeling Neutrophil Mediated Killing Of Gram-positive Bacterium Neutrophil Mediated Killing Of Fungus Macrophage Apoptotic Process Mononuclear Cell Migration Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Fibrinolysis Placenta Development Negative Regulation Of Chemokine Biosynthetic Process Negative Regulation Of Interleukin-8 Biosynthetic Process Defense Response To Bacterium	Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Somatic Stem Cell Maintenance Platelet Degranulation Regulation Of Endothelial Cell Proliferation Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway DNA Ligation Involved In DNA Recombination Regulation Of Proteolysis Negative Regulation Of Epithelial Cell Proliferation Cell Activation Response To Wounding Stem Cell Maintenance Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Inner Ear Development Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Platelet Activation Regulation Of Catalytic Activity Bone Development Ear Development Lagging Strand Elongation Pro-B Cell Differentiation Alveolar Secondary Septum Development Regulation Of Neuron Apoptotic Process Lung Development Axonogenesis Involved In Innervation Stem Cell Development Respiratory Tube Development Response To Abiotic Stimulus Response To Stimulus Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway Establishment Of Integrated Proviral Latency Ossification Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Respiratory System Development Regulation Of Epithelial Cell Proliferation Regulation Of Neuron Death Immunoglobulin V(D)J Recombination Chondrocyte Proliferation Response To L-ascorbic Acid Establishment Of Viral Latency
Tagcloud ?		abs accelerated autoantibodies autoimmune cd3 clade coadministration discovered fashion homeostasis humoral hypo immunity immunological islet limiting mab maintain nod osmotic ova prone protease proteases protecting reagent suboptimal	alkaline alp ccd cleidocranial cocultured ctr dental dspp dysplasia heterozygous interfered mineralization mineralized mmp9 mononuclear nodules ocn odontoblast opg osteoblast osteoclast partly pulp rankl remodeling retention runx2 teeth tooth
Tagcloud (Difference) ?		abs accelerated autoantibodies autoimmune cd3 clade coadministration discovered fashion homeostasis humoral hypo immunity immunological islet limiting mab maintain nod osmotic ova prone protease proteases protecting reagent suboptimal	alkaline alp ccd cleidocranial cocultured ctr dental dspp dysplasia heterozygous interfered mineralization mineralized mmp9 mononuclear nodules ocn odontoblast opg osteoblast osteoclast partly pulp rankl remodeling retention runx2 teeth tooth
Tagcloud (Intersection) ?