SRPX2 and ADAMTS4

Number of citations of the paper that reports this interaction (PMID 18718938)
10

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		SRPX2	ADAMTS4
Gene Name		sushi-repeat containing protein, X-linked 2	ADAM metallopeptidase with thrombospondin type 1 motif, 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Cell Surface Cell Junction Excitatory Synapse Synaptic Membrane	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Extracellular Matrix
	Molecular Function	Receptor Binding Protein Binding Hepatocyte Growth Factor Binding Identical Protein Binding	Protease Binding Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding
	Biological Process	Angiogenesis Single Organismal Cell-cell Adhesion Regulation Of Phosphorylation Cell Motility Positive Regulation Of Synapse Assembly Vocalization Behavior Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis	Skeletal System Development Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Defense Response To Bacterium
Pathways			Post-translational protein modification O-glycosylation of TSR domain-containing proteins Degradation of the extracellular matrix O-linked glycosylation
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: ADAMTS4 CTSB PLAUR	11 interactors: ACAN BCAN FN1 FURIN HP MT2A SERPINA1 SERPINA3 SRPX2 YTHDC1 ZBTB16
Entrez ID		27286	9507
HPRD ID		06726	04853
Ensembl ID		ENSG00000102359
Uniprot IDs		O60687	O75173
PDB IDs			2RJP 3B2Z
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Disassembly Urokinase Plasminogen Activator Signaling Pathway Extracellular Matrix Organization Extracellular Structure Organization Cellular Response To Thyroid Hormone Stimulus Attachment Of GPI Anchor To Protein Response To Thyroid Hormone Decidualization Response To Stress C-terminal Protein Lipidation Fibrinolysis Maternal Placenta Development	Acute-phase Response Acute Inflammatory Response Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Peptidase Activity Inflammatory Response Pathogenesis Regulation Of Proteolysis Defense Response Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Proteoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Negative Regulation Of Catalytic Activity Negative Regulation Of Proteolysis Platelet Degranulation Negative Regulation Of Hydrogen Peroxide Catabolic Process Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Response To Methanol Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Nerve Growth Factor Production Response To Triglyceride Glycosaminoglycan Biosynthetic Process Proteoglycan Metabolic Process Response To Inorganic Substance Negative Regulation Of Transforming Growth Factor Beta1 Production Negative Regulation Of Receptor Catabolic Process Secretion By Cell Cell Adhesion Negative Regulation Of Cellular Metabolic Process Response To Chromate Cellular Response To Erythropoietin Nerve Growth Factor Processing Calcium-independent Cell-matrix Adhesion Negative Regulation Of Hydrogen Peroxide Metabolic Process Skeletal System Development Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Cellular Response To Interleukin-3 Positive Regulation Of NK T Cell Differentiation Negative Regulation Of Transforming Growth Factor Beta Production Negative Regulation Of Serine-type Endopeptidase Activity Male Germ-line Stem Cell Asymmetric Division Secretion Regulation Of Catalytic Activity Glycosaminoglycan Metabolic Process Negative Regulation Of Serine-type Peptidase Activity
Tagcloud ?		agenesis anteriorly arx callosum dcx encompass encompasses filamin flna fronto genitalia gpr56 heterotopia lch lcha lchb lchd lissencephaly malformative mcd pachygyria perisylvian periventricular pnh polymicrogyria reln sbh tuba1a xq28	affymetrix continues crabp2 depleted differentiating directs driving exons intergenic introns luciferase master mineralization networks occupancy osteoblast osteoblastogenesis osteoblasts osteogenesis partitioned peaks performing regions remodelers runx2 termination throughput tnfrsf19 turnover
Tagcloud (Difference) ?		agenesis anteriorly arx callosum dcx encompass encompasses filamin flna fronto genitalia gpr56 heterotopia lch lcha lchb lchd lissencephaly malformative mcd pachygyria perisylvian periventricular pnh polymicrogyria reln sbh tuba1a xq28	affymetrix continues crabp2 depleted differentiating directs driving exons intergenic introns luciferase master mineralization networks occupancy osteoblast osteoblastogenesis osteoblasts osteogenesis partitioned peaks performing regions remodelers runx2 termination throughput tnfrsf19 turnover
Tagcloud (Intersection) ?