SRPX2 and ADAMTS4

Number of citations: 0 (PubMedID 18718938)
Data Source: HPRD (in vivo, two hybrid, in vitro)

		SRPX2	ADAMTS4
Name		sushi repeat containing protein X-linked 2	ADAM metallopeptidase with thrombospondin type 1 motif 4
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Cell Surface Extracellular Matrix Synapse Excitatory Synapse Synaptic Membrane Glutamatergic Synapse	Extracellular Region Extracellular Space Nuclear Speck Extracellular Matrix
	Molecular Function	Signaling Receptor Binding Extracellular Matrix Structural Constituent Protein Binding Hepatocyte Growth Factor Binding Identical Protein Binding	Protease Binding Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Angiogenesis Cell Adhesion Regulation Of Phosphorylation Cell Motility Regulation Of Synapse Assembly Positive Regulation Of Synapse Assembly Vocalization Behavior Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Cell-cell Adhesion	Skeletal System Development Proteolysis Extracellular Matrix Disassembly Proteoglycan Catabolic Process Extracellular Matrix Organization Defense Response To Bacterium
Pathways		None	Degradation of the extracellular matrix Degradation of the extracellular matrix Defective B3GALTL causes PpS O-glycosylation of TSR domain-containing proteins
Diseases		Polymicrogyria; Bilateral frontal polymicrogyria (BFP); Bilateral frontoparietal polymicrogyria (BFPP); Bilateral perisylvian polymicrogyria (BPP); Bilateral parasagittal parieto-occipital polymicrogyria (BPOP); Bilateral generalised polymicrogyria (BGP); Unilateral Polymicrogyria (ULP)	None
GWAS		No GWAS studies recorded	Alzheimer's disease or family history of Alzheimer's disease ( 30617256 ) Asthma ( 27182965 31361310 31619474 ) Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Family history of Alzheimer's disease ( 30617256 ) HDL cholesterol levels ( 32203549 ) Monocyte percentage of white cells ( 27863252 32888494 )
Interacting Genes		3 interacting genes: ADAMTS4 CTSB PLAUR	11 interacting genes: ACAN BCAN FN1 FURIN HP MT2A SERPINA1 SERPINA3 SRPX2 YTHDC1 ZBTB16
Entrez ID		27286	9507
HPRD ID		06726	04853
Ensembl ID		ENSG00000102359	ENSG00000158859
Uniprot IDs		O60687	O75173
PDB IDs		Not available	2RJP 3B2Z 4WK7 4WKE 4WKI
GO Terms Enriched among Interactors		Thyroid Hormone Generation Extracellular Region Peptidase Activity External Side Of Plasma Membrane Endolysosome Lumen Peptidase Inhibitor Complex Proteoglycan Binding Extracellular Matrix Cellular Response To Thyroid Hormone Stimulus Serine-type Endopeptidase Complex Urokinase Plasminogen Activator Receptor Activity Protein Complex Involved In Cell-matrix Adhesion Urokinase Plasminogen Activator Signaling Pathway Proteoglycan Catabolic Process Thyroid Hormone Metabolic Process Response To Thyroid Hormone Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of DNA Binding Extrinsic Component Of Membrane Regulation Of Fibrinolysis Regulation Of Plasminogen Activation Decidualization Positive Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Glycoprotein Catabolic Process Positive Regulation Of ERBB Signaling Pathway	Acute-phase Response Acute Inflammatory Response Extracellular Matrix Extracellular Space Extracellular Region Platelet Alpha Granule Lumen Perineuronal Net Serine-type Endopeptidase Inhibitor Activity Negative Regulation Of Transforming Growth Factor Beta Production Golgi Lumen Protease Binding Extracellular Matrix Structural Constituent Blood Microparticle Hyaluronic Acid Binding Central Nervous System Development Skeletal System Development Inflammatory Response Zymogen Activation Negative Regulation Of Nerve Growth Factor Production Dibasic Protein Processing Zymogen Inhibition Hepatocyte Growth Factor Binding Protein Maturation Negative Regulation Of Hydrogen Peroxide Catabolic Process Golgi Apparatus Subcompartment Regulation Of Nerve Growth Factor Production Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Nerve Growth Factor Production Negative Regulation Of Neurotrophin Production Type 2 Angiotensin Receptor Binding Primary Follicle Stage Lysosomal Lumen Cell Adhesion Negative Regulation Of Monocyte Activation Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Negative Regulation Of Receptor Catabolic Process Male Germ-line Stem Cell Asymmetric Division Mammalian Oogenesis Stage Peptidase Inhibitor Activity Calcium-independent Cell-matrix Adhesion Cellular Response To Erythropoietin Viral Translation Viral Life Cycle Germ-line Stem Cell Division Positive Regulation Of NK T Cell Differentiation MRNA Alternative Polyadenylation System Development Hemoglobin Binding Response To Erythropoietin Cytokine Precursor Processing