SRPX2 and PLAUR

Number of citations of the paper that reports this interaction (PMID 18718938)
10

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		SRPX2	PLAUR
Gene Name		sushi-repeat containing protein, X-linked 2	plasminogen activator, urokinase receptor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Cell Surface Cell Junction Excitatory Synapse Synaptic Membrane	Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Integral Component Of Membrane Extrinsic Component Of Membrane Anchored Component Of Membrane Extracellular Vesicular Exosome Invadopodium Membrane
	Molecular Function	Receptor Binding Protein Binding Hepatocyte Growth Factor Binding Identical Protein Binding	Receptor Activity Receptor Binding Protein Binding Enzyme Binding Protein Domain Specific Binding Urokinase Plasminogen Activator Receptor Activity
	Biological Process	Angiogenesis Single Organismal Cell-cell Adhesion Regulation Of Phosphorylation Cell Motility Positive Regulation Of Synapse Assembly Vocalization Behavior Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis	C-terminal Protein Lipidation Movement Of Cell Or Subcellular Component Chemotaxis Signal Transduction Blood Coagulation Attachment Of GPI Anchor To Protein Regulation Of Proteolysis Urokinase Plasminogen Activator Signaling Pathway Fibrinolysis Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways			Post-translational protein modification Attachment of GPI anchor to uPAR Dissolution of Fibrin Clot Post-translational modification: synthesis of GPI-anchored proteins
Drugs			Alteplase Urokinase Reteplase Anistreplase Tenecteplase
Diseases
GWAS
Protein-Protein Interactions		3 interactors: ADAMTS4 CTSB PLAUR	20 interactors: EEF1A1 ELAVL1 FAP FYN HCK IGF2R IL6ST ITGAM ITGB1 JAK1 KNG1 LRP1 LRP1B MMP12 PFN2 PLAU SRPX2 SURF2 TYK2 VTN
Entrez ID		27286	5329
HPRD ID		06726	01421
Ensembl ID		ENSG00000102359	ENSG00000011422
Uniprot IDs		O60687	M0R1I2 Q03405
PDB IDs			1YWH 2FD6 2I9B 3BT1 3BT2 3U73 3U74
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Disassembly Urokinase Plasminogen Activator Signaling Pathway Extracellular Matrix Organization Extracellular Structure Organization Cellular Response To Thyroid Hormone Stimulus Attachment Of GPI Anchor To Protein Response To Thyroid Hormone Decidualization Response To Stress C-terminal Protein Lipidation Fibrinolysis Maternal Placenta Development	Cell Motility Cell Migration Locomotion Peptidyl-tyrosine Autophosphorylation Movement Of Cell Or Subcellular Component Regulation Of Immune Response Regulation Of Cell Proliferation Regulation Of Collagen Catabolic Process Peptidyl-tyrosine Phosphorylation Regulation Of Immune System Process Regulation Of Cell Migration Regulation Of Smooth Muscle Cell Migration Defense Response Wound Healing Regulation Of Cell Adhesion Regulation Of Cell Motility Developmental Process Endocytosis Regulation Of Apoptotic Process Negative Regulation Of Blood Coagulation Regulation Of Locomotion Regulation Of Cellular Component Movement Response To Wounding Negative Regulation Of Coagulation Regulation Of Cell Death Blood Coagulation Hemostasis Protein Autophosphorylation Negative Regulation Of Wound Healing Cell Adhesion Leukocyte Migration Innate Immune Response Regulation Of Innate Immune Response Cell Adhesion Mediated By Integrin Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Blood Coagulation Regulation Of Cellular Component Organization Regulation Of Body Fluid Levels Vesicle-mediated Transport Activated T Cell Proliferation Integrin-mediated Signaling Pathway Regulation Of Wound Healing Response To Stress Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Receptor-mediated Endocytosis Regulation Of Cellular Process Regulation Of Defense Response To Virus By Virus Positive Regulation Of Cell Adhesion Extracellular Matrix Organization
Tagcloud ?		agenesis anteriorly arx callosum dcx encompass encompasses filamin flna fronto genitalia gpr56 heterotopia lch lcha lchb lchd lissencephaly malformative mcd pachygyria perisylvian periventricular pnh polymicrogyria reln sbh tuba1a xq28	alters ap attributed cascade chemo chief designating erk1 fos fra govern isoform mapk microrna mir mirna multifaceted next oncogenic serpine1 shortening singular snail thousands transcriptome transcriptomes tumorigenesis utrs zeb1
Tagcloud (Difference) ?		agenesis anteriorly arx callosum dcx encompass encompasses filamin flna fronto genitalia gpr56 heterotopia lch lcha lchb lchd lissencephaly malformative mcd pachygyria perisylvian periventricular pnh polymicrogyria reln sbh tuba1a xq28	alters ap attributed cascade chemo chief designating erk1 fos fra govern isoform mapk microrna mir mirna multifaceted next oncogenic serpine1 shortening singular snail thousands transcriptome transcriptomes tumorigenesis utrs zeb1
Tagcloud (Intersection) ?