COMMD1 and XIAP

Number of citations of the paper that reports this interaction (PMID 14685242)
73

Data Source:
HPRD (two hybrid, in vivo)

		COMMD1	XIAP
Gene Name		copper metabolism (Murr1) domain containing 1	X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Early Endosome Cul2-RING Ubiquitin Ligase Complex Recycling Endosome Extracellular Vesicular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol Spindle Microtubule
	Molecular Function	Copper Ion Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Identical Protein Binding Protein Homodimerization Activity Phosphatidylinositol-3,4-bisphosphate Binding Phosphatidic Acid Binding Phosphatidylinositol-3,5-bisphosphate Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
	Biological Process	Golgi To Plasma Membrane Transport Positive Regulation Of Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Plasma Membrane To Endosome Transport Copper Ion Homeostasis Negative Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Protein Localization To Cell Surface	Apoptotic Process Cellular Response To DNA Damage Stimulus Wnt Signaling Pathway Protein Ubiquitination Regulation Of BMP Signaling Pathway Positive Regulation Of Protein Ubiquitination Regulation Of Cell Proliferation Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Innate Immune Response Regulation Of Inflammatory Response Copper Ion Homeostasis Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Mitotic Spindle Assembly Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Linear Polyubiquitination Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Pathways			misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling SMAC binds to IAPs SMAC-mediated dissociation of IAP:caspase complexes SMAC-mediated apoptotic response Signaling by Wnt deactivation of the beta-catenin transactivating complex Apoptotic factor-mediated response TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation Programmed Cell Death XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer Intrinsic Pathway for Apoptosis
Drugs			1-[3,3-Dimethyl-2-(2-Methylamino-Propionylamino)-Butyryl]-Pyrrolidine-2-Carboxylic Acid(1,2,3,4-Tetrahydro-Naphthalen-1-Yl)-Amide N-METHYLALANYL-3-METHYLVALYL-4-PHENOXY-N-(1,2,3,4-TETRAHYDRONAPHTHALEN-1-YL)PROLINAMIDE
Diseases
GWAS
Protein-Protein Interactions		27 interactors: BAHCC1 BARD1 BRCA1 COMMD10 COMMD2 COMMD3 COMMD4 COMMD5 COMMD6 COMMD7 COMMD8 CUL1 CUL2 CUL3 CUL4A CUL4B CUL5 CUL7 KAT2A LIG4 NFKBIA RELA SLC12A2 SOCS1 SPP1 TCEB1 XIAP	67 interactors: ACVRL1 AFP AIFM1 AKT1 AKT2 BIRC5 BRCA1 CASP10 CASP3 CASP7 CASP9 CHEK1 CKS1B COMMD1 DIABLO DTX3 DYNLL2 ELAVL1 ERCC3 GSPT1 HTRA1 HTRA2 IKBKE INPP5D LONRF1 MAGED1 MAP3K2 MAP3K3 MAP3K7 NEK6 NOD1 NOD2 NOTCH1 RAF1 RFC5 RIPK1 RIPK2 RIPK3 RIPK4 SEPT4 SSX2IP STRADB STUB1 TAB1 TAB2 TBK1 TGFBR1 TRAF6 TRIM32 TRIM8 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2I UBE2J2 UBE2N UBE2V1 UBE2V2 UBE2W VPS37C WDYHV1 XAF1
Entrez ID		150684	331
HPRD ID		06253	02094
Ensembl ID			ENSG00000101966
Uniprot IDs		Q8N668	B2R9R2 P98170
PDB IDs		2H2M	1C9Q 1F9X 1G3F 1G73 1I3O 1I4O 1I51 1KMC 1NW9 1TFQ 1TFT 2ECG 2JK7 2KNA 2OPY 2OPZ 2POI 2POP 2QRA 2VSL 3CLX 3CM2 3CM7 3EYL 3G76 3HL5 3UW4 3UW5 4EC4 4HY0 4IC2 4IC3 4J3Y 4J44 4J45 4J46 4J47 4J48
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Viral Process Intrinsic Apoptotic Signaling Pathway Cell Cycle Arrest Ubiquitin-dependent Protein Catabolic Process Response To Stress Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Response To Stress Apoptotic Signaling Pathway Cellular Protein Catabolic Process Protein Catabolic Process Regulation Of Cell Cycle Cellular Response To Stimulus Apoptotic Process Cell Cycle Negative Regulation Of Cell Cycle Programmed Cell Death Cell Death Death Response To Abiotic Stimulus Regulation Of Cell Proliferation G1/S Transition Of Mitotic Cell Cycle Cellular Macromolecule Catabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cellular Process Intracellular Signal Transduction Cell Cycle Process Response To Stimulus Proteolysis Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cellular Protein Modification Process Regulation Of Metabolic Process Protein Monoubiquitination Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Protein Metabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Protein Catabolic Process Positive Regulation Of Cell Cycle Phase Transition Protein K6-linked Ubiquitination Mitotic Cell Cycle Process Negative Regulation Of NF-kappaB Transcription Factor Activity Protein Metabolic Process Mitotic Cell Cycle Positive Regulation Of Protein Catabolic Process Positive Regulation Of Cell Cycle Process Positive Regulation Of Metabolic Process	Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Toll-like Receptor 4 Signaling Pathway Regulation Of Cellular Protein Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Regulation Of Protein Metabolic Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Apoptotic Process Activation Of Innate Immune Response Programmed Cell Death Cell Death Death Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Response To Stress Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Innate Immune Response Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Stress Positive Regulation Of Protein Modification Process Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Signal Transduction Protein Metabolic Process Protein Polyubiquitination Regulation Of I-kappaB Kinase/NF-kappaB Signaling Immune Response-regulating Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Transferase Activity Regulation Of Innate Immune Response Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Signal Transduction By Phosphorylation Innate Immune Response Regulation Of Signal Transduction Cellular Protein Modification Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Metabolic Process Protein Ubiquitination Regulation Of Apoptotic Process Protein Modification By Small Protein Conjugation Positive Regulation Of Catalytic Activity Regulation Of Cell Death Apoptotic Signaling Pathway Regulation Of Signaling Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Apoptotic Process
Tagcloud ?		beneficial cart comparative considering edged eradication hiv ikappab infected innate jak latency latent lymphoid murr1 parental poses proteasomal reactivation reinforcing respective restriction retroviral sets stabilized suppressing sword tnfalpha toll	anthracyclines antiapoptotic apaf bcp carbinol childhood coadministration cruciferous cure doxorubicin dramatic evidenced i3c iap1 indole innovative lymphoblastic modality nalm nontoxic noxa opportunities parp phytochemical potentiates puma topoisomerase vegetables xl
Tagcloud (Difference) ?		beneficial cart comparative considering edged eradication hiv ikappab infected innate jak latency latent lymphoid murr1 parental poses proteasomal reactivation reinforcing respective restriction retroviral sets stabilized suppressing sword tnfalpha toll	anthracyclines antiapoptotic apaf bcp carbinol childhood coadministration cruciferous cure doxorubicin dramatic evidenced i3c iap1 indole innovative lymphoblastic modality nalm nontoxic noxa opportunities parp phytochemical potentiates puma topoisomerase vegetables xl
Tagcloud (Intersection) ?