COMMD1 and C2orf74

		COMMD1	C2orf74
Description		copper metabolism domain containing 1	chromosome 2 open reading frame 74
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Endosome Membrane Membrane Cytoplasmic Vesicle Cul2-RING Ubiquitin Ligase Complex Recycling Endosome	Membrane
	Molecular Function	Copper Ion Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Lipid Binding Sodium Channel Inhibitor Activity Identical Protein Binding Protein Homodimerization Activity Phosphatidylinositol-3,4-bisphosphate Binding Metal Ion Binding Phosphatidic Acid Binding Phosphatidylinositol-3,5-bisphosphate Binding	Protein Binding
	Biological Process	Nucleotide-excision Repair Golgi To Plasma Membrane Transport Protein Transport Positive Regulation Of Protein Ubiquitination Protein Destabilization Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Low-density Lipoprotein Particle Clearance Protein Localization To Cell Surface Cholesterol Homeostasis Plasma Membrane To Endosome Transport Copper Ion Homeostasis Regulation Of Plasma Lipoprotein Particle Levels Negative Regulation Of Hypoxia-inducible Factor-1alpha Signaling Pathway Negative Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Cholesterol Import Positive Regulation Of Endosome To Plasma Membrane Protein Transport Negative Regulation Of Protein Localization To Cell Surface Positive Regulation Of Protein Localization To Cell Surface
Pathways		Neddylation
Drugs
Diseases
GWAS		Age-related nuclear cataracts ( 33311586) Erectile dysfunction ( 30583798) Height ( 31562340) Iron status biomarkers (total iron binding capacity) ( 28334935) Iron status biomarkers (transferrin saturation) ( 28334935) Mean corpuscular volume ( 27863252) Nonalcoholic fatty liver disease ( 31311600)	Crohn's disease ( 21102463 22412388) High light scatter reticulocyte percentage of red cells ( 32888494) Inflammatory bowel disease ( 23128233)
Interacting Genes		36 interacting genes: BAHCC1 BARD1 BRCA1 COMMD10 COMMD2 COMMD3 COMMD4 COMMD5 COMMD6 COMMD7 COMMD8 CUL1 CUL2 CUL3 CUL4A CUL4B CUL5 CUL7 ELOC GRSF1 HMGB2 KAT2A LIG4 NFKBIA PRKN RELA RIPPLY3 SLC12A2 SOCS1 SOD1 SPP1 TCEAL8 TMEM132D UPRT VHL XIAP	2 interacting genes: POT1 SMAGP
Entrez ID		150684	339804
HPRD ID		06253	19550
Ensembl ID		ENSG00000173163	ENSG00000237651
Uniprot IDs		Q8N668	A8MZ97 C9JBF1
PDB IDs		2H2M 8F2R 8F2U 8P0W
Enriched GO Terms of Interacting Partners?		Cullin-RING Ubiquitin Ligase Complex Ubiquitin Ligase Complex Scaffold Activity Protein Ubiquitination Ubiquitin Protein Ligase Binding Protein Modification By Small Protein Conjugation Post-translational Protein Modification NF-kappaB Binding Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Ubiquitin-protein Transferase Activity Protein Polyubiquitination Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Cellular Response To Stress Protein Modification Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Intrinsic Apoptotic Signaling Pathway Nucleoplasm Positive Regulation Of Protein Linear Polyubiquitination Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Nucleus Regulation Of Multicellular Organismal Development Apoptotic Signaling Pathway Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Cell Development Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway SCF Ubiquitin Ligase Complex Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex Regulation Of DNA Damage Checkpoint Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Developmental Process Regulation Of Cellular Response To Insulin Stimulus Protein K6-linked Ubiquitination BRCA1-B Complex Cytokine-mediated Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Intracellular Signal Transduction Catabolic Process Proteolysis Cellular Response To Radiation Cytoplasm Regulation Of Cytokine Production Negative Regulation Of Cell Communication	Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Nuclear Polyadenylation-dependent MRNA Catabolic Process Polyribonucleotide Nucleotidyltransferase Activity Positive Regulation Of Cholesterol Import Positive Regulation Of Telomeric Loop Disassembly 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding RRNA Transport RRNA Import Into Mitochondrion Positive Regulation Of Mitochondrial RNA Catabolic Process Mitochondrial Degradosome Mitochondrial MRNA Catabolic Process Negative Regulation Of Hypoxia-inducible Factor-1alpha Signaling Pathway Positive Regulation Of Endosome To Plasma Membrane Protein Transport Telomeric D-loop Binding Telomere Assembly Mitochondrial MRNA Polyadenylation Mitochondrial RNA 5'-end Processing Regulation Of Plasma Lipoprotein Particle Levels Single-stranded Telomeric DNA Binding RNA Import Into Mitochondrion Regulation Of Cholesterol Import Shelterin Complex Mitochondrial RNA 3'-end Processing Exoribonuclease Complex Positive Regulation Of MiRNA Catabolic Process Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Mitochondrial RNA Catabolic Process DEAD/H-box RNA Helicase Binding Poly(G) Binding Sodium Channel Inhibitor Activity Positive Regulation Of Endocytic Recycling Nuclear Telomere Cap Complex Telomeric D-loop Disassembly Negative Regulation Of Sodium Ion Transmembrane Transport G-rich Strand Telomeric DNA Binding Plasma Membrane To Endosome Transport Telomeric Loop Disassembly Telomere Capping Negative Regulation Of Protein Localization To Cell Surface MKS Complex Negative Regulation Of Cellular Response To Hypoxia Protein Homotrimerization Negative Regulation Of Sodium Ion Transport Response To Growth Hormone Low-density Lipoprotein Particle Clearance Regulation Of DNA Strand Elongation
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