COMMD1 and COMMD4

Number of citations of the paper that reports this interaction (PubMedID 15799966)
0

Data Source:
HPRD (in vitro)

		COMMD1	COMMD4
Description		copper metabolism domain containing 1	COMM domain containing 4
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Endosome Membrane Membrane Cytoplasmic Vesicle Cul2-RING Ubiquitin Ligase Complex Recycling Endosome	Nucleus Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Copper Ion Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Lipid Binding Sodium Channel Inhibitor Activity Identical Protein Binding Protein Homodimerization Activity Phosphatidylinositol-3,4-bisphosphate Binding Metal Ion Binding Phosphatidic Acid Binding Phosphatidylinositol-3,5-bisphosphate Binding	Protein Binding
	Biological Process	Nucleotide-excision Repair Golgi To Plasma Membrane Transport Protein Transport Positive Regulation Of Protein Ubiquitination Protein Destabilization Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Low-density Lipoprotein Particle Clearance Protein Localization To Cell Surface Cholesterol Homeostasis Plasma Membrane To Endosome Transport Copper Ion Homeostasis Regulation Of Plasma Lipoprotein Particle Levels Negative Regulation Of Hypoxia-inducible Factor-1alpha Signaling Pathway Negative Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Cholesterol Import Positive Regulation Of Endosome To Plasma Membrane Protein Transport Negative Regulation Of Protein Localization To Cell Surface Positive Regulation Of Protein Localization To Cell Surface	Signal Transduction
Pathways		Neddylation	Neddylation
Drugs
Diseases
GWAS		Age-related nuclear cataracts ( 33311586) Erectile dysfunction ( 30583798) Height ( 31562340) Iron status biomarkers (total iron binding capacity) ( 28334935) Iron status biomarkers (transferrin saturation) ( 28334935) Mean corpuscular volume ( 27863252) Nonalcoholic fatty liver disease ( 31311600)	Microalbuminuria ( 31511532) Serum uric acid levels ( 30993211) Urate levels ( 31578528) Urinary albumin-to-creatinine ratio ( 31511532)
Interacting Genes		36 interacting genes: BAHCC1 BARD1 BRCA1 COMMD10 COMMD2 COMMD3 COMMD4 COMMD5 COMMD6 COMMD7 COMMD8 CUL1 CUL2 CUL3 CUL4A CUL4B CUL5 CUL7 ELOC GRSF1 HMGB2 KAT2A LIG4 NFKBIA PRKN RELA RIPPLY3 SLC12A2 SOCS1 SOD1 SPP1 TCEAL8 TMEM132D UPRT VHL XIAP	4 interacting genes: BUB1B COMMD1 H2AC4 TBCD
Entrez ID		150684	54939
HPRD ID		06253	13083
Ensembl ID		ENSG00000173163	ENSG00000140365
Uniprot IDs		Q8N668	A0A0B4J287 H3BQF2 Q9H0A8
PDB IDs		2H2M 8F2R 8F2U 8P0W	8F2R 8F2U 8P0W
Enriched GO Terms of Interacting Partners?		Cullin-RING Ubiquitin Ligase Complex Ubiquitin Ligase Complex Scaffold Activity Protein Ubiquitination Ubiquitin Protein Ligase Binding Protein Modification By Small Protein Conjugation Post-translational Protein Modification NF-kappaB Binding Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Ubiquitin-protein Transferase Activity Protein Polyubiquitination Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Cellular Response To Stress Protein Modification Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Intrinsic Apoptotic Signaling Pathway Nucleoplasm Positive Regulation Of Protein Linear Polyubiquitination Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Nucleus Regulation Of Multicellular Organismal Development Apoptotic Signaling Pathway Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Cell Development Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway SCF Ubiquitin Ligase Complex Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex Regulation Of DNA Damage Checkpoint Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Developmental Process Regulation Of Cellular Response To Insulin Stimulus Protein K6-linked Ubiquitination BRCA1-B Complex Cytokine-mediated Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Intracellular Signal Transduction Catabolic Process Proteolysis Cellular Response To Radiation Cytoplasm Regulation Of Cytokine Production Negative Regulation Of Cell Communication	Protein Localization To Chromosome, Centromeric Region Protein Localization To Chromosome Positive Regulation Of Cholesterol Import Mitotic Checkpoint Complex Meiotic Sister Chromatid Cohesion, Centromeric Negative Regulation Of Hypoxia-inducible Factor-1alpha Signaling Pathway Positive Regulation Of Endosome To Plasma Membrane Protein Transport Regulation Of Plasma Lipoprotein Particle Levels Regulation Of Cholesterol Import Metaphase/anaphase Transition Of Mitotic Cell Cycle Metaphase/anaphase Transition Of Cell Cycle Post-chaperonin Tubulin Folding Pathway Sodium Channel Inhibitor Activity Positive Regulation Of Endocytic Recycling Tubulin Complex Assembly Plasma Membrane To Endosome Transport Negative Regulation Of Sodium Ion Transmembrane Transport Meiotic Sister Chromatid Cohesion Negative Regulation Of Protein Localization To Cell Surface Adherens Junction Assembly Negative Regulation Of Microtubule Polymerization Negative Regulation Of Sodium Ion Transport Negative Regulation Of Cellular Response To Hypoxia Low-density Lipoprotein Particle Clearance Intracellular Protein Localization Outer Kinetochore CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Regulation Of Endocytic Recycling Cul2-RING Ubiquitin Ligase Complex Copper Ion Homeostasis Positive Regulation Of Protein Localization To Cell Surface Anaphase-promoting Complex Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Cellular Response To Hypoxia Protein Localization To Organelle Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Centrosome Phosphatidylinositol-3,5-bisphosphate Binding Phosphatidylinositol-3,4-bisphosphate Binding Protein Localization To Cell Surface Phosphatidic Acid Binding Plasma Lipoprotein Particle Clearance Positive Regulation Of Cholesterol Transport Negative Regulation Of Cellular Component Organization Negative Regulation Of Mitotic Nuclear Division Chromosome Beta-tubulin Binding Regulation Of Sodium Ion Transmembrane Transport
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