COMMD1 and WDPCP

		COMMD1	WDPCP
Description		copper metabolism domain containing 1	WD repeat containing planar cell polarity effector
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Endosome Membrane Membrane Cytoplasmic Vesicle Cul2-RING Ubiquitin Ligase Complex Recycling Endosome	Cytoplasm Cytoskeleton Plasma Membrane Cilium Axoneme Cell Cortex Membrane Apical Plasma Membrane Cell Projection Axonemal Basal Plate
	Molecular Function	Copper Ion Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Lipid Binding Sodium Channel Inhibitor Activity Identical Protein Binding Protein Homodimerization Activity Phosphatidylinositol-3,4-bisphosphate Binding Metal Ion Binding Phosphatidic Acid Binding Phosphatidylinositol-3,5-bisphosphate Binding	Phosphatidylinositol Binding
	Biological Process	Nucleotide-excision Repair Golgi To Plasma Membrane Transport Protein Transport Positive Regulation Of Protein Ubiquitination Protein Destabilization Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Low-density Lipoprotein Particle Clearance Protein Localization To Cell Surface Cholesterol Homeostasis Plasma Membrane To Endosome Transport Copper Ion Homeostasis Regulation Of Plasma Lipoprotein Particle Levels Negative Regulation Of Hypoxia-inducible Factor-1alpha Signaling Pathway Negative Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Cholesterol Import Positive Regulation Of Endosome To Plasma Membrane Protein Transport Negative Regulation Of Protein Localization To Cell Surface Positive Regulation Of Protein Localization To Cell Surface	Establishment Of Planar Polarity Kidney Development Auditory Receptor Cell Morphogenesis Smoothened Signaling Pathway Nervous System Development Regulation Of Fibroblast Migration Regulation Of Embryonic Cell Shape Neural Tube Development Cell Projection Organization Septin Cytoskeleton Organization Regulation Of Protein Localization Intraciliary Transport Embryonic Digit Morphogenesis Camera-type Eye Development Tongue Morphogenesis Cilium Organization Establishment Of Protein Localization Embryonic Organ Development Regulation Of Focal Adhesion Assembly Digestive System Development Roof Of Mouth Development Cilium Assembly Respiratory System Development Circulatory System Development Podocyte Cell Migration Regulation Of Ruffle Assembly Regulation Of Cilium Assembly Regulation Of Establishment Of Cell Polarity
Pathways		Neddylation
Drugs
Diseases
GWAS		Age-related nuclear cataracts ( 33311586) Erectile dysfunction ( 30583798) Height ( 31562340) Iron status biomarkers (total iron binding capacity) ( 28334935) Iron status biomarkers (transferrin saturation) ( 28334935) Mean corpuscular volume ( 27863252) Nonalcoholic fatty liver disease ( 31311600)	Academic attainment (English) ( 33594131) Anxiety ( 33859377) Asthma and attention deficit hyperactivity disorder ( 31619474) Childhood ear infection ( 27182965) Cutaneous malignant melanoma ( 26237428) Depression ( 33859377) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) General factor of neuroticism ( 30867560) General risk tolerance (MTAG) ( 30643258) Number of sexual partners ( 30643258) Obesity-related traits ( 23251661) Prostate cancer ( 31562322) Regular attendance at a religious group ( 29970889) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		36 interacting genes: BAHCC1 BARD1 BRCA1 COMMD10 COMMD2 COMMD3 COMMD4 COMMD5 COMMD6 COMMD7 COMMD8 CUL1 CUL2 CUL3 CUL4A CUL4B CUL5 CUL7 ELOC GRSF1 HMGB2 KAT2A LIG4 NFKBIA PRKN RELA RIPPLY3 SLC12A2 SOCS1 SOD1 SPP1 TCEAL8 TMEM132D UPRT VHL XIAP
Entrez ID		150684	51057
HPRD ID		06253	14228
Ensembl ID		ENSG00000173163	ENSG00000143951
Uniprot IDs		Q8N668	O95876
PDB IDs		2H2M 8F2R 8F2U 8P0W	7Q3D
Enriched GO Terms of Interacting Partners?		Cullin-RING Ubiquitin Ligase Complex Ubiquitin Ligase Complex Scaffold Activity Protein Ubiquitination Ubiquitin Protein Ligase Binding Protein Modification By Small Protein Conjugation Post-translational Protein Modification NF-kappaB Binding Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Ubiquitin-protein Transferase Activity Protein Polyubiquitination Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Cellular Response To Stress Protein Modification Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Intrinsic Apoptotic Signaling Pathway Nucleoplasm Positive Regulation Of Protein Linear Polyubiquitination Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Nucleus Regulation Of Multicellular Organismal Development Apoptotic Signaling Pathway Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Cell Development Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway SCF Ubiquitin Ligase Complex Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex Regulation Of DNA Damage Checkpoint Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Developmental Process Regulation Of Cellular Response To Insulin Stimulus Protein K6-linked Ubiquitination BRCA1-B Complex Cytokine-mediated Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Intracellular Signal Transduction Catabolic Process Proteolysis Cellular Response To Radiation Cytoplasm Regulation Of Cytokine Production Negative Regulation Of Cell Communication	Calcium-dependent Protein Serine/threonine Phosphatase Activity Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of Monoatomic Ion Transport Negative Regulation Of Transmembrane Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Cytosol Regulation Of Protein Stability Astral Microtubule Nuclear Polyadenylation-dependent MRNA Catabolic Process RRNA Transport RRNA Import Into Mitochondrion Positive Regulation Of Mitochondrial RNA Catabolic Process Mitochondrial Degradosome Mitochondrial MRNA Catabolic Process Polyribonucleotide Nucleotidyltransferase Activity Negative Regulation Of Hypoxia-inducible Factor-1alpha Signaling Pathway Positive Regulation Of Cholesterol Import Positive Regulation Of Endosome To Plasma Membrane Protein Transport Negative Regulation Of Calcium Ion Import Across Plasma Membrane Calcium-dependent Protein Serine/threonine Phosphatase Regulator Activity Calcineurin Complex ScaRNA Localization To Cajal Body N-acetyllactosaminide Beta-1,3-N-acetylglucosaminyltransferase Activity Poly-N-acetyllactosamine Biosynthetic Process Mitochondrial MRNA Polyadenylation Mitochondrial RNA 3'-end Processing Exoribonuclease Complex RNA Import Into Mitochondrion Positive Regulation Of MiRNA Catabolic Process Mitochondrial RNA 5'-end Processing Regulation Of Cholesterol Import Regulation Of Plasma Lipoprotein Particle Levels
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